Navigation Links
Older men more likely than women to die after pneumonia
Date:4/29/2009

ir first day of hospitalization.

Men had a higher risk than women of death at 30 days (7 percent vs. 4.5 percent), 90 days (11.4 percent vs. 8.6 percent) and one year (21 percent vs. 16 percent). "Even compared to women with an equivalent illness severity, men were more likely to die," Dr. Yende noted. "Survival differences persist up to one year after the initial hospitalization, when most patients had recovered from the pneumonia and left the hospital."

"To our knowledge, this is the largest study comparing biological response to infection between men and women. Our results suggest that immune response to infection may be an important target for interventions to reduce sex disparities in the outcomes of infections," said senior author Derek C. Angus, M.D., professor and chair in the Department of Critical Care Medicine at the University of Pittsburgh School of Medicine and principal investigator of the study.

"More studies will be needed to determine why the biological response differs between men and women," said Dr. Yende. "A clearer understanding may be useful toward designing interventions specifically targeted to men or women."

The GenIMS researchers hope to identify whether certain changes in the genes for key inflammatory molecules are associated with the risk of developing pneumonia, and the risk of progression to severe sepsis, septic shock, organ dysfunction or death. Because pneumonia is the most common cause of sepsis, patients with this infection represent an excellent clinical model for studying sepsis in a relatively homogeneous population.

In a paper published online on April 3 in The FASEB Journal, GenIMS researchers led by Drs. Yende and Angus found that people with certain gene variations associated with higher levels of macrophage migration inhibitory factor, an innate immune response regulator, were less likely to die following CAP.

"Macrophage migration inhibitory factor is a molecule
'/>"/>

Contact: Frank Raczkiewicz
RaczkiewiczFA@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Older climbers face uphill battle on Mount Everest
2. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
3. High blood pressure in older adults traced to genes effects in blood vessels
4. Worlds largest investor coalition seeks further disclosure on climate change and shareholder value
5. Stakeholders use science to find common ground on wood supply from forests
6. RING finger protein 5 may guide treatment for muscle disease in older adults
7. Testosterone replacement theraphy beneficial in men 60 and older
8. BIO-key(R) Issues Open Letter to Shareholders
9. Older people who diet without exercising lose valuable muscle mass
10. Pain is in the eyes of the beholder
11. Research finds older women who are more physically fit have better cognitive function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... SAN JOSE, Calif. , Nov. 20, 2014 /PRNewswire/ ... a global leader in microcontroller (MCU) and touch technology ... digital temperature sensors with the widest V ... family delivers higher temperature accuracy and faster I 2 ... nonvolatile registers and serial EEPROM memory making them ideal ...
(Date:11/18/2014)... , Nov. 17, 2014 The Parenteral Drug Association ... regulatory agencies will speak and at least seven more will ... at the Omni Shoreham Hotel in Washington D.C. ... again to have significant support from the regulatory agencies in ... Europe in our effort to help advance the ...
(Date:11/12/2014)... PALM BEACH GARDENS, Fla. , Nov. 12, 2014 ... management solutions, announced today that its U.are.U ® ... upscale retail bakery chain in Central Mexico ... solution in June 2014 to eliminate payroll issues caused ... Prior to installing the U.are.U fingerprint readers, Montparnasse ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... by which Helicobacter pylori , the only known cancer-causing ... The new study, in the journal Oncogene , reports ... pylori infection and stomach cancer, the second leading cause ... population is infected with H. pylori, a bacterium that can ...
... MADISON, WI, August 2nd, 2010 - Using little more than ... get a feel for soil water retention and field capacity, ... to engineering. The demonstration, developed by Adam Howard, Drs. ... was designed to illustrate concepts that can be difficult for ...
... research points to a genetic route to understanding and treating ... Penn State University, has identified an ancient gene family that ... the brain. "In healthy people, nerves do not fire ... us to focus on what really matters. Nerve cells ...
Cached Biology News:Cancer-causing bacterium targets tumor-suppressor protein 2Cancer-causing bacterium targets tumor-suppressor protein 3Students get a feel for soil-water relationships 2Epileptic seizures may be linked to an ancient gene family 2
(Date:12/19/2014)... December 18, 2014 LayerBio is an ... and wound care. The National Eye Institute (NEI) at ... a Phase I SBIR grant to develop a drug-eluting ... the most common cause of vision loss in people ... worldwide. According to Dr. Ken Mandell, LayerBio’s Founder and ...
(Date:12/19/2014)... iLab Solutions, the global leader in core facility ... the new Director of Institutional Implementations and Sarah Becker ... new leadership positions were created to support iLab’s mission ... continues to meet the needs of its growing customer ... been deployed at over 450 core facilities across more ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 With only ... time special on Sartorius Biohit products . The ... mLINE pipettes, Picus Electronic Pipette Trade-in Program, and free ... and Safety officers around the world. They are ideal ... Other features include:, ,     Full volume range ...
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... Ahn Brings ZyGEM Extensive Expertise in Developing and ... Commercializing Novel Clinical Products--, SOLANA BEACH, Calif., ... and innovative enzymatic solutions for DNA,extraction and detection and other ... Ph.D., as Chair of its newly,formed Clinical Advisory Board. Dr. ...
... Feb. 14 Biodel Inc. (Nasdaq:,BIOD) today reported financial ... net loss for the quarter was $11.0 million or ... Phase III clinical trials of,VIAject(TM) positions us to meet ... FDA by the end of 2008," stated Dr. Solomon ...
... 14 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ... pharmaceutical and,medical device company, today announced unaudited ... fourth quarter and year ended,December 31, 2007. ... further,review and potential adjustment as described under ...
Cached Biology Technology:ZyGEM Appoints Leading Biotechnology Expert to Head Clinical Advisory Board 2ZyGEM Appoints Leading Biotechnology Expert to Head Clinical Advisory Board 3Biodel Inc. Reports First Quarter Fiscal Year 2008 Financial Results 2Biodel Inc. Reports First Quarter Fiscal Year 2008 Financial Results 3Biodel Inc. Reports First Quarter Fiscal Year 2008 Financial Results 4Biodel Inc. Reports First Quarter Fiscal Year 2008 Financial Results 5Biodel Inc. Reports First Quarter Fiscal Year 2008 Financial Results 6Biodel Inc. Reports First Quarter Fiscal Year 2008 Financial Results 7Angiotech announces results for the fourth quarter ended December 31, 2007 2Angiotech announces results for the fourth quarter ended December 31, 2007 3Angiotech announces results for the fourth quarter ended December 31, 2007 4Angiotech announces results for the fourth quarter ended December 31, 2007 5Angiotech announces results for the fourth quarter ended December 31, 2007 6Angiotech announces results for the fourth quarter ended December 31, 2007 7Angiotech announces results for the fourth quarter ended December 31, 2007 8Angiotech announces results for the fourth quarter ended December 31, 2007 9Angiotech announces results for the fourth quarter ended December 31, 2007 10Angiotech announces results for the fourth quarter ended December 31, 2007 11Angiotech announces results for the fourth quarter ended December 31, 2007 12Angiotech announces results for the fourth quarter ended December 31, 2007 13Angiotech announces results for the fourth quarter ended December 31, 2007 14Angiotech announces results for the fourth quarter ended December 31, 2007 15Angiotech announces results for the fourth quarter ended December 31, 2007 16Angiotech announces results for the fourth quarter ended December 31, 2007 17Angiotech announces results for the fourth quarter ended December 31, 2007 18Angiotech announces results for the fourth quarter ended December 31, 2007 19Angiotech announces results for the fourth quarter ended December 31, 2007 20Angiotech announces results for the fourth quarter ended December 31, 2007 21Angiotech announces results for the fourth quarter ended December 31, 2007 22Angiotech announces results for the fourth quarter ended December 31, 2007 23Angiotech announces results for the fourth quarter ended December 31, 2007 24
...
... collection and automation that is controlled from ... with Microsoft Excel , Pre-configured library ... density meters, force gauges, spectrophotometers, etc ... be added and configured by the user ...
DNA sequencing - plasmids or PCR fragments, 3-7 working days service....
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Biology Products: