Navigation Links
Older men more likely than women to die after pneumonia
Date:4/29/2009

PITTSBURGH, April 29 Differing biological response to infection between men and women may explain higher death rates among older men who are hospitalized with community-acquired pneumonia (CAP). The findings, published online in the Critical Care Medicine journal, may have important implications for understanding sex differences in life expectancy.

"Our study found that men with CAP were less likely to survive after an infection compared to women and this was not explained by differences in demographics, health behavior, chronic health conditions or quality of care," said Sachin Yende, M.D., assistant professor in the Department of Critical Care Medicine at the University of Pittsburgh School of Medicine and corresponding author of the study.

The researchers measured blood levels of inflammatory indicators, including tumor necrosis factor (TNF) and interleukins 6 and 10, coagulation indicators including Factor IX, and fibrinolysis indicators including D-dimer concentrations. They found patterns in these biomarkers that suggest men generate a stronger inflammatory and coagulation response and, perhaps, break up blood clots more quickly than women in response to infection. "These differences in inflammatory, coagulation and fibrinolysis biomarkers among men may explain the reduced short-term and long-term survival," said Dr. Yende.

Data were gathered from the multicenter Genetic and Inflammatory Markers of Sepsis (GenIMS) study. Participants were enrolled upon emergency department admission at 28 academic and community hospitals in Pennsylvania, Connecticut, Michigan and Tennessee from 2001 to 2003. The study included 2,320 subjects, with a mean age of 64.9 years, 1,136 of whom were men. The men were sicker on admission, more likely to be smokers, and had at least one chronic health condition, such as cardiac disease or cancer. Severe sepsis occurred in 588 (31 percent) subjects. Of these, about half had severe sepsis on the
'/>"/>

Contact: Frank Raczkiewicz
RaczkiewiczFA@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Older climbers face uphill battle on Mount Everest
2. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
3. High blood pressure in older adults traced to genes effects in blood vessels
4. Worlds largest investor coalition seeks further disclosure on climate change and shareholder value
5. Stakeholders use science to find common ground on wood supply from forests
6. RING finger protein 5 may guide treatment for muscle disease in older adults
7. Testosterone replacement theraphy beneficial in men 60 and older
8. BIO-key(R) Issues Open Letter to Shareholders
9. Older people who diet without exercising lose valuable muscle mass
10. Pain is in the eyes of the beholder
11. Research finds older women who are more physically fit have better cognitive function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... , March 12, 2015 IriTech, a ... a member of the Texas Instruments Design Network, announced ... has demonstrated its IriShield USB MK2120U device during ... facility for pension distribution. The iris ... to be marketed in India ...
(Date:3/11/2015)... March 11, 2015   The Sync Project™ ... to scientifically measure and harness music to improve ... biometrics and objective measurements of physiology, enabling the ... scale in large populations. It is designed for ... clinicians perform rigorous studies and accelerate the discovery ...
(Date:3/5/2015)... -- In Brazil , cloud computing is ... solutions and 42 percent planning to invest in them by ... of the companies will be investing in these solutions for ... in the region are currently opting for the private cloud ... significant attention in the coming years. This trend is in ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
... in German . The Deutsche Forschungsgemeinschaft ... new Research Units. This decision was taken by the DFG,s ... the research consortia is to offer researchers the opportunity to ... to establish innovative research directions. As with all ...
... Sandia,s decontamination foam, developed more than a decade ago ... during the 2001 anthrax attacks, is now being used ... chemical engineer in Sandia,s Chemical & Biological Systems Dept. ... renders all types of typical chemical and biological agents ...
... Ganges River ,and Irrawaddy dolphins declared by the ... study ,with Bangladesh Forest Department helped pinpoint location ... The Government of Bangladesh recently declared three new ... world,s largest mangrove ecosystem the Sundarbans, according ...
Cached Biology News:DFG to establish 4 new research units 2DFG to establish 4 new research units 3Anthrax-killing foam proves effective in meth lab cleanup 2Anthrax-killing foam proves effective in meth lab cleanup 3Anthrax-killing foam proves effective in meth lab cleanup 4New protected areas for dolphins declared 2New protected areas for dolphins declared 3
(Date:3/26/2015)... Ale Gicqueau, Founder and President of Clinovo, ... at Align Technology, on “ Conducting Postmarket Registries - ... Global Conference and Exhibition on April 25th through April ... the poster presentation, Ale Gicqueau and Victor Chen will ... Registry, the requirements and resources to conduct the registry, ...
(Date:3/25/2015)... MN (PRWEB) March 26, 2015 Agnition ... upcoming episode of American Farmer, airing for the first ... The segment of American Farmer will explore the extremely ... provides crop producers with a patented Microbial Catalyst™ technology ... and greater yields. The segment will air again on ...
(Date:3/25/2015)... The surging prevalence of internet use ... media growth, with over 50% of the world’s ... Insurance companies are making use of social media ... a diversity of their services and products. , ... networking services as part of sales and marketing, ...
(Date:3/25/2015)... , March 25, 2015 Accelovance, a ... a finalist for "Best Contract Research Organization" at the ... World Vaccine Congress. This is the ... finalist for the award, winning for "Best Contract Research ... "Highly Recommended" distinction in 2013. "We,re excited ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2
... Inc. (Amex:,ADL), headquartered in Tustin, California, with ... its wholly owned subsidiary Jade,Pharmaceutical Inc. (Jade), ... that Jade has received the Brand Excellence ... Commerce for its state-of-the-art,anti-aging treatment Goodnak(R)., ...
... to Retain Pfizer Assets, Talent, ANN ARBOR, Mich., ... million by the state of Michigan through the 21st ... state of Michigan loan,fund with a low interest rate, ... talent in the region. Job creation is vital for,consideration ...
... Center for Molecular,Medicine (CMM) today announced its role ... (http://www.xceedmolecular.com ; Wellesley, MA) collaborator program., In ... to offer Xceed Molecular,s new,Ziplex(R) system for gene ... disease investigation and drug discovery. Analysis of,gene expression ...
Cached Biology Technology:AMDL's Chinese Subsidiary Wins Key Brand Excellence Award for Anti-Aging Treatment 2Ann Arbor SPARK Receives $3.75M from Michigan's Company Formation & Growth Fund 2Ann Arbor SPARK Receives $3.75M from Michigan's Company Formation & Growth Fund 3Center for Molecular Medicine Offers Xceed Ziplex(TM) Services to Research Community 2
Rat Aortic Endothelial Cells (RAOEC) (>500,000 cells)...
... Model 440 incorporates four channels of sophisticated ... easy-to-use instrument. Each channel consists of a ... lowpass filter, a highpass filter, a line ... control knob sets the amplifier parameters and ...
... licensed, high throughput, water bath thermal cycler capable ... microplates. This equates to 9,216 reactions per run ... arm rapidly transfers a basket of plates between ... that are considerably faster than those of peltier ...
... is a four-channel general purpose laboratory amplifier. It ... sources which may have a large common-mode level ... a high gain/low noise amplifier, an input coupling ... offset control. A control knob sets the amplifier ...
Biology Products: