Navigation Links
Old stain in a new combination
Date:5/20/2009

New combinations of agents based on the oldest synthetic malaria drug, the methylene blue stain, can curb the spread of malaria parasites and make a significant contribution to the long-term eradication called for by the international "Roll Back Malaria Initiative." In a study on 160 children with malaria in Burkina Faso, specialists in tropical medicine from the Heidelberg University Hospital have shown that in combination with newer malaria drugs, methylene blue prevents the malaria pathogen in infected persons from being re-ingested by mosquitoes and then transmitted to others and is thus twice as effective as the standard therapy. The results of the study were published in May 2009 in the online journal PLoS One.

Malaria is still one of the deadliest tropical diseases. Every year, 300 million people are infected with malaria and more than one million of them die or suffer severe brain damage. Children under five years are particularly susceptible.

Malaria pathogens need humans and mosquitoes

When the Anopheles mosquito bites, the malaria parasites (plasmodia) in the saliva of the mosquito enter the human body, reproduce in liver cells and then attack the red blood cells. This causes severe symptoms such as high fever or anemia; children in particular can even fall into a coma. During reproduction in the human body, some parasites develop into special reproductive cells, gametocytes. If they are ingested by an Anopheles mosquito, they continue to reproduce in the mosquito. The cycle is complete.

The gametocytes are the key for the spread of malaria by the Anopheles mosquito. Common malaria drugs known as artemisinins block reproduction of the parasites in the human body and reduce the number of gametocytes in blood by half. This makes the transmission of the parasite to the mosquito more difficult but does not completely prevent it. "We urgently need alternative therapies that are effective against the gam
'/>"/>

Contact: Prof. Olaf Mueller
Olaf.mueller@urz.uni-heidelberg.de
49-062-215-65035
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Grasslands: The future of sustainable agriculture
2. Going bananas for sustainable research -- scientists create fuel from African crop waste
3. K-State biologist collaborating with researchers in Africa on grassland sustainability, biodiversity
4. Organizational Change Management for Sustainability: The Harvard Case Study
5. Biofuels can provide viable, sustainable solution to reducing petroleum dependence
6. Symposium at UH will address how to put sustainability into practice
7. Biggest ever public investment in bioenergy to help provide clean, green and sustainable fuels
8. TXOTX, coordinated international project to contribute to sustainability of the marine resources
9. Abundance of ladybugs in olive orchards is an indicator of health and sustainability
10. Next generation microscopy: No stain, big gain
11. New publishing partnership for Energy for Sustainable Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... This news release is available in German . ... for only a very few drugs. When treating overdoses, doctors ... Treatment is especially difficult if there is a combination of ... is playing and accidentally swallows his grandmother,s pills? ETH professor ... Zurich wanted to find an answer to this question. "The ...
(Date:10/16/2014)... monocultures can be cultivated efficiently, they are anything ... caused by monoculture cultivation is becoming increasingly evident. ... crop form and are regarded as the sole ... – quite wrongfully, finds Bernhard Schmid, an ecology ... a novel form of agriculture and forestry. After ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... identified a weakness in the defenses of the anthrax ... The researchers found that nitric oxide (NO) is ... immune response launched by cells infected with the bacterium. ... immune system,s attack. Stephen Lippard, the Arthur Amos ...
... tiny that 30 can fit across the width of a human ... organisms taking the greenhouse gas carbon dioxide out of the Earths ... they die in the oceans they typically sink to watery graves ... locking it into sediments below. This week in the online ...
... computer-based text-searching tool developed by UT Southwestern Medical Center ... in a database for similarities, providing a more efficient ... offering scientific journal editors a new tool to thwart ... efficient at flagging publications that are highly similar, said ...
Cached Biology News:Team IDs weakness in anthrax bacteria 2Ecologists, material scientists pursue genetics of diatom's elegant, etched casing 2Ecologists, material scientists pursue genetics of diatom's elegant, etched casing 3Computer-based tool aids research, helps thwart questionable publication practices 2Computer-based tool aids research, helps thwart questionable publication practices 3
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by ... Type & by Geography - Forecasts & Analysis ... vehicle market into various sub segments with an ... report also identifies the factors driving this market, ... the adoption trends. , The unmanned ground vehicle ...
(Date:10/18/2014)... The Asia-Pacific Bio-based Advanced Phase Change Materials Market ... change material market in Asia-Pacific with analysis and ... of the Asia-Pacific Bio-based Advanced Phase Change Materials ... in-depth analysis provided. This also provides a glimpse ... phase change material market, and is supported by ...
(Date:10/18/2014)... 2014 The Asia-Pacific hardware encryption display ... Asia-Pacific with analysis and forecast of revenue. This market ... to reach $51,362.6 million by 2018, at a CAGR ... the TOC of the Asia-Pacific hardware encryption market report, ... This also provides a glimpse of the segmentation of ...
(Date:10/18/2014)... The Biomass Power industry has ... to 2014. The industry's expansion has been propelled in ... encouraged the use of biomass power. Furthermore, the majority ... require local utilities to generate electricity from renewable power ... campaigning for green technology also influenced industry performance by ...
Breaking Biology Technology:Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... bond initiative to fund stem-cell research, under pressure from advocacy ... , ,Ten of the initiative's 29 board members hold significant ... the Sacramento Bee reported. They won't have to relinquish stock ... of Regenerative Medicine will have to give up or put ...
... capital, having received plenty of it in his time ... denizen of Silicon Valley and recent emigrant to Madison, ... with Badger Ventures of Wisconsin , a nascent ... and management services to entrepreneurs in the information-technology sector. ...
badgernet badgernet badgernet ,badgernet badgernet badgernet ,badgernet badgernet badgernet ,badgernet badgernet badgernet badgernet badgernet...
Cached Biology Technology:New Madison VC firm Badger Ventures looks for next big IT entrepreneurs 2New Madison VC firm Badger Ventures looks for next big IT entrepreneurs 3
... Analytical System more than doubles the benefits ... The fast analysis cycles of the standard ... 100% in tandem mode. Difficult separations are ... backflush or heartcut configurations, on-line sample preparation ...
... Components in this kit are prepared ... technology. Biochains Mitochondria Isolation Kit is ... in a fast and easy way. One ... performing 100 isolations (enriching mitochondria from 10 ...
... plasmid DNA preparations are prepared from ... from 1mg to multi-gram scales. ... (100mg-multi-gram) preparations are made according to ... formulated according to customer needs, and ...
... Activins are polypeptide hormones which ... (TGF-) superfamily. The TGF- superfamily is ... factors which control many aspects of ... (1). Other members incude TGF-s, bone ...
Biology Products: