Navigation Links
Old flies can become young moms
Date:11/24/2008

Female flies can turn back the biological clock and extend their lifespan at the same time, University of Southern California biologists report.

Their study, published online this month in Molecular Genetics and Genomics, casts doubt on the old notion of a tradeoff between reproduction and longevity.

Popular wisdom and scientific opinion have held that "the more you reproduce, the shorter you're going to live," said senior author John Tower, associate professor of biological sciences at USC College.

While that may be true in some cases, Tower added, recent research has hinted at exceptions to the rule.

The latest study is a striking example.

Tower and graduate student Yishi Li screened 8,000 genes in search of ones that could make older flies lay more eggs. They found two.

When older female flies were altered to over-express either of these two genes, they lived 5 to 30 percent longer and produced more offspring.

Tower speculated that the genes are boosting activity of stem cells in the flies' reproductive system. Stem cell activity declines with age, and reproduction in older flies could not happen without a return of stem cells to peak form.

"This would appear to be stimulating the stem cells to divide more in the old fly and therefore produce more offspring," Tower said.

Next, Tower and Li plan to see if stem cells in other parts of the fly's body also returned to their youthful prime.

If they did, over-expression of the two genes would seem to act as a fountain of youth for the entire organism.

The implications for mammals are not clear, Tower said, though one of the genes has a human equivalent that helps cells to grow and blood vessels to form.

But Tower's method at least provides a proof of concept.

"It both makes females lay more eggs and live longer, so it really argues against any kind of obligatory tradeoff between reproduction and lifespan," Tower said.


'/>"/>

Contact: Carl Marziali
marziali@usc.edu
213-219-6347
University of Southern California
Source:Eurekalert

Related biology news :

1. Making flies sick reveals new role for growth factors in immunity
2. Painful heat sensed by painless in flies
3. Old before their time? Aging in flies under natural vs. laboratory conditions
4. Brain tweak lets sleep-deprived flies stay sharp
5. Courtship pattern shaped by emergence of a new gene in fruit flies
6. Monarch butterflies help explain why parasites harm hosts
7. Fruit flies show how salmonella escapes immune defenses
8. CSHL scientists identify a mechanism that helps fruit flies lock-in memories
9. Smell-wars between butterflies and ants
10. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
11. Tiny pest-eating insect fights fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... , Feb. 22, 2017 With the ... ABI Research identifies four technologies that innovative and ... secure significant share in the changing competitive landscape: ... passive authentication.   "Companies can no ... to security," says Dimitrios Pavlakis , Industry ...
(Date:2/21/2017)... LONDON , February 21, 2017 ... um 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr ... es einige Hindernisse zu überwinden gilt, um diese Prognose ... ... unter anderem die Mobilisierung der finanziellen Mittel für die ...
(Date:2/14/2017)... Feb. 14, 2017  Wake Forest Baptist Medical Center ... new chief executive officer (CEO). Freischlag joins the medical ... D. McConnell , M.D., who last year announced that ... Medical Center, after leading it since 2008.   ... of Wake Forest Baptist,s academic health system, which includes ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... Malden, MA (PRWEB) , ... March 23, 2017 ... ... as, “a viscoelastic material that exhibits both viscous and elastic characteristics when deformed, ... AxioMed disc polymer exhibits properties to gently absorb compressive forces and return to ...
(Date:3/23/2017)... Mass. , March 23, 2017 /PRNewswire/ ... partner to global in vitro diagnostics manufacturers ... of the industry,s first multiplexed Inherited ... disease testing by next-generation sequencing (NGS). The ... were developed with input from industry experts ...
(Date:3/23/2017)... , March 23, 2017 Kineta, ... development of novel therapies in immuno-oncology, today announced ... lead" small molecule compounds that activate interferon response ... pathways and demonstrate immune-mediated tumor regression in a ... the study who demonstrated complete tumor regression to ...
(Date:3/23/2017)... 23, 2017 In today,s pre-market ... in the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), ... MKT: SYN), and Regulus Therapeutics Inc. (NASDAQ: ... Credit Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." ... report at: ...
Breaking Biology Technology: