Navigation Links
Old flies can become young moms
Date:11/24/2008

Female flies can turn back the biological clock and extend their lifespan at the same time, University of Southern California biologists report.

Their study, published online this month in Molecular Genetics and Genomics, casts doubt on the old notion of a tradeoff between reproduction and longevity.

Popular wisdom and scientific opinion have held that "the more you reproduce, the shorter you're going to live," said senior author John Tower, associate professor of biological sciences at USC College.

While that may be true in some cases, Tower added, recent research has hinted at exceptions to the rule.

The latest study is a striking example.

Tower and graduate student Yishi Li screened 8,000 genes in search of ones that could make older flies lay more eggs. They found two.

When older female flies were altered to over-express either of these two genes, they lived 5 to 30 percent longer and produced more offspring.

Tower speculated that the genes are boosting activity of stem cells in the flies' reproductive system. Stem cell activity declines with age, and reproduction in older flies could not happen without a return of stem cells to peak form.

"This would appear to be stimulating the stem cells to divide more in the old fly and therefore produce more offspring," Tower said.

Next, Tower and Li plan to see if stem cells in other parts of the fly's body also returned to their youthful prime.

If they did, over-expression of the two genes would seem to act as a fountain of youth for the entire organism.

The implications for mammals are not clear, Tower said, though one of the genes has a human equivalent that helps cells to grow and blood vessels to form.

But Tower's method at least provides a proof of concept.

"It both makes females lay more eggs and live longer, so it really argues against any kind of obligatory tradeoff between reproduction and lifespan," Tower said.


'/>"/>

Contact: Carl Marziali
marziali@usc.edu
213-219-6347
University of Southern California
Source:Eurekalert

Related biology news :

1. Making flies sick reveals new role for growth factors in immunity
2. Painful heat sensed by painless in flies
3. Old before their time? Aging in flies under natural vs. laboratory conditions
4. Brain tweak lets sleep-deprived flies stay sharp
5. Courtship pattern shaped by emergence of a new gene in fruit flies
6. Monarch butterflies help explain why parasites harm hosts
7. Fruit flies show how salmonella escapes immune defenses
8. CSHL scientists identify a mechanism that helps fruit flies lock-in memories
9. Smell-wars between butterflies and ants
10. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
11. Tiny pest-eating insect fights fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... Germany (PRWEB) , ... July 14, 2017 , ... ... standardized solution for sample preparation of proteins to clean peptides for mass spectrometry ... sonication system. , The PreOmics iST Kit is based on proprietary technology ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... ... URAC accreditation in Specialty Pharmacy. URAC is the independent leader in promoting healthcare ... demonstrated a comprehensive commitment to quality care, improved processes and better patient outcomes. ...
(Date:7/13/2017)... ... July 13, 2017 , ... FireflySci ... standards. Blast forward seven years and now they are home to a ... for wavelength accuracy, and resolution testing. , One mega advantage ...
(Date:7/13/2017)... ... July 13, 2017 , ... After 11 ... City Science Center, Christopher Laing, MRCVS, Ph.D. has been tapped to lead the ... Laing will become the first Executive Director at the newly formed Capital City ...
Breaking Biology Technology: