Navigation Links
Old drug may teach new tricks in treating infectious diseases, cancer
Date:10/30/2013

inhibiting mitochondrial respiration, they made a couple of fundamental observations. "First, when we add this drug to the whole cells, we see reduced respiration, not rapidly but slowly," he said.

The researchers then added the drug to isolated mitochondria, which is the main site of respiration within the cells.

"But we did not see an effect, so that gave us the idea that this drug may not be directly targeting one of the enzymes of mitochondria which are required for or participates in consuming oxygen," Gohil said. "We used that clue to figure out how non-mitochondrial pathways could be targeted by this drug."

He used an unbiased metabolic profiling approach, a new technology that gives a snapshot of metabolite levels before and after the treatment of a drug so researchers can get an idea of how this drug is perturbing these metabolites.

"Through metabolic profiling, we found one particular metabolite - phosphoethanolamine - was in fact 'going through the roof' within a few hours of the treatment," Gohil said. "We got excited about that."

He explained that phosphoethanolamine is an intermediate in a biosynthetic pathway of a common phospholipid that forms the membrane around the cells. It is present in all living matter from the lower organisms such as bacteria all the way to humans. Thus, finding that the metabolite that was elevated when cells were treated with meclizine indicated a link between this pathway, or metabolite, and respiration.

"Our research showed that if we just take this metabolite and directly add it to mitochondria, it actually inhibits the respiration," Gohil said. "The reason we could use the drug for infectious disease or cancer is not because it inhibits respiration but because it inhibits a phospholipid biosynthetic enzyme that is required to form the building blocks of membranes."


'/>"/>

Contact: Kathleen Phillips
ka-phillips@tamu.edu
979-845-2872
Texas A&M AgriLife Communications
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Teaching about hearing can save young peoples ears
2. A birds song may teach us about human speech disorders
3. Mini-CT scanner developed as a teaching tool
4. 800-year-old farmers could teach us how to protect the Amazon
5. Desert to Rainforest global classroom links future teachers, classrooms in Phoenix and Panama
6. SF State biology department receives $1.5 million to support science teaching
7. RATS research may teach rodents to detect explosives
8. MARC travel awards announced for 2012 Institute on Teaching and Mentoring
9. Teaching a microbe to make fuel
10. Partnership enhances biology teaching at California community colleges
11. SMU professor Louis Jacobs honored with prestigious award from Texas science teachers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Old drug may teach new tricks in treating infectious diseases, cancer
(Date:7/10/2014)... Intelligence today released forecasts from "The Global National eID ... for National Electronic ID (eID) programs will generate $54 billion ... number of National eID cards in circulation will double from ... with its vast population, will dominate the market representing nearly ... Europe trails a distant second at 11%. ...
(Date:7/10/2014)... for Basic Science (IBS), the main organization of the ... has announced that a group of researchers, led by ... in the field of optogenetics that can remotely control ... technology "OptoTrk" and it has succeeded with neuronal differentiation ... is that it requires only light to activate neuronal ...
(Date:7/10/2014)... even improve the state of fisheries resources in ... Mediterranean has deteriorated over the past 20 years. ... reported in the Cell Press journal Current ... stringent monitoring of Mediterranean fishing activities, better enforcement ... Mediterranean waters. , Their data show that the ...
Breaking Biology News(10 mins):National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2New optogenetic tool for controlling neuronal signalling by blue light 2Mediterranean fish stocks show steady decline 2
... found a new way that DNA can carry out its ... mold used to cast a metal tool can also serve ... distinct functional roles. Professor Manolis Kellis and postdoctoral research ... the journal Genes & Development that in certain DNA sequences, ...
... E-Ticketing Solution from BIO-key and Advanced Public Safety ... Officer Risk, Reduces Cost and Increases ... Fla., Jan. 10 /PRNewswire-FirstCall/,-- BIO-key International, Inc. (OTC ... and wireless public safety solutions,and Advanced Public Safety ...
... Cold Spring Harbor, NY Cold Spring Harbor Laboratorys ... Joans Legacy: The Joan Scarangello Foundation to Conquer Lung ... cancer research involving a new class of genetic mutations ... lung cancer, the leading cause of cancer deaths in ...
Cached Biology News:MIT reports new twist in microRNA biology 2Missouri Police Department Introduces Electronic Traffic Citations 2Missouri Police Department Introduces Electronic Traffic Citations 3Missouri Police Department Introduces Electronic Traffic Citations 4Cold Spring Harbor Laboratory's lung cancer research program awarded $100,000 grant 2
(Date:1/15/2014)... Niagara Thermal Products is proud to announce that ... ("B3") as the critical thermal component supplier in support ... Corps of Engineers.  B3 has developed the only comprehensive ... destroys VOCs and other chemical pollutants, allergens and organic ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... , Jan. 15, 2014 ­ RedBrick Health ... behavior change technology, today announces that EmblemHealth , ... and wellness company, is now providing the RedBrick Compass ... coaching program, to all of its members. EmblemHealth is ...
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... the University of Pennsylvania demonstrates a more consistent and ... has promising applications in a variety of fields, and ... Physics. As explained in a recently published study, ... graphene that is just a single atom thick over ...
... QUINCY, Mass., March 2, 2011 Myriant Technologies, ... of renewable bio-based chemicals, announces the addition of ... effective immediately.  Mr. Ferguson, 56, is the former ... global chemical company engaged in the manufacture and ...
... N.C., March 2, 2011 Cempra Pharmaceuticals Inc. today ... executive officer, will present at the Cowen and Company ... March 7, 2011, at The Boston Marriott Copley Place ... the company,s two leading antibiotic clinical programs, solithromycin for ...
Cached Biology Technology:Penn physicists develop scalable method for making graphene 2Penn physicists develop scalable method for making graphene 3Myriant Technologies, Inc. Announces J. Brian Ferguson to Join Advisory Board 2
... The Jouan MSC series of Class ... working conditions and certification to the ... regulation ensures that the cabinets cannot ... conditions. Natural lighting, low noise and ...
... Fluoroskan Ascent is a ... flexibility for all kinds of ... research and for clinical applications. ... biology are all important application ...
... with class-leading features, the 1400 Series will maximize your ... and consistent every time you use it. ... power consumption by as much as 50% from competitive ... of the cabinet. Multiply this savings by the ...
... for paramagnetic bead precipitation from standard 96-well ... with no additional accessories. The stand has ... SBS 96-well microplate footprint. The use of ... and fast (as little as 30 seconds) ...
Biology Products: