Navigation Links
Ohr Pharmaceutical and CSHL joint venture to develop trodusquemine, related analogs
Date:3/6/2014

acterized target for a range of therapy areas. Despite its extensive validation, PTP1B has been a challenging target for therapeutic development due to the chemical properties of the enzyme at its active site. Novel approaches are required to exploit this important target fully. In one such approach, we have identified Trodusquemine as a selective, allosteric inhibitor of PTP1B that exerts its effects outside the active site of the enzyme. Trodusquemine has also been shown to cross the blood brain barrier, which enhances its potential applications, and has been well tolerated in dose escalation and dose ranging clinical studies completed to date in over 65 patients. Analogs of Trodusquemine have been identified that are potent inhibitors of PTP1B and have potential delivery route advantages.


'/>"/>

Contact: Press Office
publicaffairs@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Michael Rice
mrice@lifesciadvisors.com
646-597-6987
LifeSci Advisors, LLC

Press Office
ir@ohrpharmaceutical.com
877-215-4813
Ohr Pharmaceutical Inc.
Source:Eurekalert


Page: 1 2

Related biology news :

1. Faster testing of new pharmaceuticals
2. Inovio Pharmaceuticals CEO Receives 2013 Drug Discovery & Achievement Award
3. Profil Institute Appoints Dan Bradbury, former Amylin Pharmaceutical CEO, to Board of Directors
4. Scripps Research announces research & license agreement with Janssen Pharmaceuticals
5. Ben-Gurion U. researchers and Teva Pharmaceutical Industries Ltd. develop psoriasis drug
6. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
7. Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
8. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
9. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
10. Global Biotech and Pharmaceutical Conference Early Bird Registration Discounts End This Week
11. Conatus Pharmaceuticals Appoints Mark F. Morris as Head of Biostatistics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... -- The 2014 Holiday Season may be the brightest ... Intelligence reports that the long anticipated floodgates for ... that intensifying demand for smart phones, tablets, and ... a global market of 2.5 billion users with ... According to Maxine Most , ...
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and ... addition of the "Micro Market Monitor: North America ... http://photos.prnewswire.com/prnh/20130307/600769 ... grow at a CAGR of 3.6% from 2014 to ... in this market, Canada is ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ... team and bring LaunchKey to market in 2015. ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... - Resistant wheat plants stave off attacks by Hessian fly ... to absorb nutrients, according to a study by Purdue University ... midguts - similar to human intestines - were observed in ... midgut function. Those that were given nothing to eat showed ...
... Allergies and Infectious Diseases (NIAID), part of the National ... totaling $15,254,919 to Tulane University for its ongoing efforts ... viral disease that threatens hundreds of thousands of people ... potential bioterrorism threat. The contract will include collaboration ...
... seems, are going on a diet, while others have ... rapidly rising temperatures due to global climate change, speculates ... Zoology, who has been measuring the evolving body sizes ... is most extreme. , Changes are happening primarily in ...
Cached Biology News:Resistant wheat goes for the gut to protect against Hessian flies 2Tulane receives $15 million NIH contract to develop vaccine and treatment for deadly fever 2Animals cope with climate change at the dinner table 2
(Date:12/24/2014)... Pipette.com announces their Holiday in ... submit their #HolidayInTheLab pictures for a chance to win ... For those struggling to think of a holiday gift ... the Lab Contest provides the ideal holiday presents. The ... send pictures of their chemistree, holiday sweaters, as well ...
(Date:12/24/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ) ... Application (CTA) with the United Kingdom,s ... approval to initiate clinical trials for the continued development ... on the Company receiving CTA regulatory approval, the Company ... the safety, tolerability and dose escalation of Anatabine Citrate ...
(Date:12/22/2014)... CHAPEL HILL, N.C. , Dec. 22, 2014 ... ALNE) today announced that it has signed a ... biotechnology company that has developed and patented a ... and medical diagnostics products that enable rapid on-site ... and alcohol use/abuse and health issues in an ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced ... , a network of more than 20 contributing ... have fast access to a national pool of frozen ... Fertility Associates of Memphis is the only fertility clinic ... , Dr. William Kutteh , director of Fertility ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... The nation's dysfunctional healthcare system may undermine any ... electronic health records, according to a featured speaker at this ... Grossman Dr. Jeff Grossman, president and CEO of the ... the role of IT in healthcare delivery. As he outlined ...
... as much as buildings and there are many stakeholders. But ... involved and excited, said presenters at the Digital Healthcare ... absolutely essential," said Peter Strombom, CIO of Meriter Hospital ... don't feel they're being heard, you're going to have trouble ...
... Santiago that research projects on his campus will get ... laugh at you. , ,"Let's get real," Santiago told ... of higher education in Wisconsin. "(UW-Milwaukee research programs) are ... periods of their evolution." , ,Likewise, don't suggest to ...
Cached Biology Technology:U.S. health system could undermine EHR progress 2U.S. health system could undermine EHR progress 3Healthcare leaders tell how they rally stakeholders around IT 2Why Milwaukee needs its own thriving research base 2Why Milwaukee needs its own thriving research base 3
Complexin-1/2 (FL-134)...
...
... (human, porcine) Endogenous potent vasoconstrictor ... receptor and modulates vascular tonus. ET-1, ET-2, ... distinct endothelin genes. ET-2 and ET-3 are ... and six amino acids, respectively. All three ...
HNF-1 Purified Anti-Mouse, Anti-Rat, Anti-Rabbit, Anti-Human clone 2, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Biology Products: