Navigation Links
Ohr Pharmaceutical and CSHL joint venture to develop trodusquemine, related analogs
Date:3/6/2014

acterized target for a range of therapy areas. Despite its extensive validation, PTP1B has been a challenging target for therapeutic development due to the chemical properties of the enzyme at its active site. Novel approaches are required to exploit this important target fully. In one such approach, we have identified Trodusquemine as a selective, allosteric inhibitor of PTP1B that exerts its effects outside the active site of the enzyme. Trodusquemine has also been shown to cross the blood brain barrier, which enhances its potential applications, and has been well tolerated in dose escalation and dose ranging clinical studies completed to date in over 65 patients. Analogs of Trodusquemine have been identified that are potent inhibitors of PTP1B and have potential delivery route advantages.


'/>"/>

Contact: Press Office
publicaffairs@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Michael Rice
mrice@lifesciadvisors.com
646-597-6987
LifeSci Advisors, LLC

Press Office
ir@ohrpharmaceutical.com
877-215-4813
Ohr Pharmaceutical Inc.
Source:Eurekalert


Page: 1 2

Related biology news :

1. Faster testing of new pharmaceuticals
2. Inovio Pharmaceuticals CEO Receives 2013 Drug Discovery & Achievement Award
3. Profil Institute Appoints Dan Bradbury, former Amylin Pharmaceutical CEO, to Board of Directors
4. Scripps Research announces research & license agreement with Janssen Pharmaceuticals
5. Ben-Gurion U. researchers and Teva Pharmaceutical Industries Ltd. develop psoriasis drug
6. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
7. Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
8. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
9. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
10. Global Biotech and Pharmaceutical Conference Early Bird Registration Discounts End This Week
11. Conatus Pharmaceuticals Appoints Mark F. Morris as Head of Biostatistics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... OXFORD, Conn. , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: ... growing mobile commerce market, reports on the recent success of the Wocket™ ... Wocket smart wallet was named as one of the ... of the "5 Best Products Launched At CES So Far" by Newseveryday.com ...
(Date:1/22/2015)... MUNICH , January 22, 2015 ... its tenth year  The European Patent Office to present ... Two British nominations to be featured: Christofer Toumazou ... week featuring former finalists and winners of the Award   ...
(Date:1/22/2015)... Infinisource has launched its new NXG series of time clocks ... a higher standard for collecting attendance and labor data and ... installation, touch screen interface and seamless connection to cloud-based iSolved, ... solution for the small to mid-size employer. The ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2
... -- Mimicking the human nervous system for bionic applications could ... at Oak Ridge National Laboratory to process carbon nanotubes. ... them attractive to use as artificial neural bundles in prosthetic ... fibers to match that of a real neuron bundle. With ...
... Mich.---Heating and squishing microalgae in a pressure-cooker can fast-forward ... University of Michigan professors are working to understand and ... development of affordable biofuels that could replace fossil fuels ... the possibility of other new fuel sources such as ...
... famous by Charles Darwin, have a unique biota now ... and population growth. Indeed, alien or exotic insects today ... of these insect invaders is the cottony cushion scale, ... of infesting many woody ornamentals and crops, the cottony ...
Cached Biology News:New ORNL carbon composite holds promise for bionics 2Pressure-cooking algae into a better biofuel 2UC Riverside entomologists say biocontrol of insect pest in the Galapagos Islands is a major success 2UC Riverside entomologists say biocontrol of insect pest in the Galapagos Islands is a major success 3
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... 23, 2014 GMO corn cases filed across ... in the process of being consolidated in a Kansas federal ... Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 in ... Management of the Syngenta GMO corn multidistrict litigation (MDL) has ...
(Date:12/24/2014)... December 23, 2014 On Friday, December ... the Omnibus and Continuing Resolution Appropriations Act of 2015, ... eligible to receive funding through the Congressionally Directed Medical ... (DoD). The Hydrocephalus Association (HA), working in conjunction with ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... Nov. 26 Signalife, Inc. (Amex:,SGN - News) ... sell - without,prescription - its ambulatory event recorder ... market as the Fidelity 200 HeartLife,Tempo Card, is ... device which will be used as an early-detection,device ...
... NEW YORK, Nov. 26 The worldwide burn treatment ... $1.9 billion. Wound,Care Markets, Volume II: Burns, a new ... a few ups and downs due to price,constraints, new ... $700 million by 2011., Conventional, mature products continue ...
... Surgeons and Rheumatologists Performing More Procedures, WALTHAM, ... Acid (HA) Viscosupplementation Marketrack(TM) service, which,captures data from ... provided more HA knee injections in Q3 2007 ... both groups, there are substantial,differences in the products ...
Cached Biology Technology:Signalife Receives FDA Clearance for OTC Non-Prescription Event Recorder Device 2Signalife Receives FDA Clearance for OTC Non-Prescription Event Recorder Device 3Bio-advancements Expected to Drive Burn Care Market Growth Up $700 Million 2Hyaluronic Acid Knee Procedures Grow 38% from Q3 2006 to Q3 2007 2
... may be carried out using this high ... System control and data processing is provided ... The elegant, powerful and very easy to use ... and 2000., The supplied automatic sample injector has ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (F1676) or contact customer s...
... a new product number, created to ... showing no availability yet, please order ... or contact customer service for assistance. ... 11.25 6.40 in. Mfr ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: