Navigation Links
Ohr Pharmaceutical and CSHL joint venture to develop trodusquemine, related analogs
Date:3/6/2014

NEW YORK, New York On March 3, 2014, Ohr Pharmaceutical (NasdaqCM: OHRP), a pharmaceutical company focused on the development of novel therapeutics for large unmet medical needs, and leading global cancer research center Cold Spring Harbor Laboratory (CSHL) today announced the establishment of DepYmed Inc., a new joint venture to develop trodusquemine and related analogs.

The new joint venture will be a private entity, initially with equal ownership by Ohr and Cold Spring Harbor Laboratory. The two partners will seek funding and contribute to the research and development of trodusquemine and also newly patented analogs. The goal is to take the program into the clinic and to demonstrate proof of concept. Various options to fund later stage clinical trials will be explored. The continued preclinical research will be conducted under the guidance of Dr. Nicholas Tonks at CSHL.

"Cold Spring Harbor Laboratory is a world class research center that has a track record of establishing successful commercial ventures in the biopharma space," said Irach Taraporewala, President and Chief Executive Officer of Ohr. "We are very pleased to be working with Dr. Nicholas Tonks who is one of the leading authorities on the protein tyrosine phosphatase (PTP) family of enzymes. Dr. Tonks discovered PTP1B, the primary target for trodusquemine. Setting up this joint venture is the optimal way to create shareholder value from this exciting asset and enable it to obtain the appropriate resources. At the same time, Ohr remains focused on the execution of our core strategy to develop novel ophthalmology products."

"At CSHL we strive to bring the benefits of biological research to society," said Teri Willey, Vice President for Business Development and Technology Transfer at CSHL. "We hope that our involvement in this joint venture leads to new therapies that will benefit patients."

The enzyme protein tyrosine phosphatase 1B (PTB1B) is a well-characterized target for a range of therapy areas. Despite its extensive validation, PTP1B has been a challenging target for therapeutic development due to the chemical properties of the enzyme at its active site. Novel approaches are required to exploit this important target fully. In one such approach, we have identified Trodusquemine as a selective, allosteric inhibitor of PTP1B that exerts its effects outside the active site of the enzyme. Trodusquemine has also been shown to cross the blood brain barrier, which enhances its potential applications, and has been well tolerated in dose escalation and dose ranging clinical studies completed to date in over 65 patients. Analogs of Trodusquemine have been identified that are potent inhibitors of PTP1B and have potential delivery route advantages.


'/>"/>

Contact: Press Office
publicaffairs@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Michael Rice
mrice@lifesciadvisors.com
646-597-6987
LifeSci Advisors, LLC

Press Office
ir@ohrpharmaceutical.com
877-215-4813
Ohr Pharmaceutical Inc.
Source:Eurekalert


Related biology news :

1. Faster testing of new pharmaceuticals
2. Inovio Pharmaceuticals CEO Receives 2013 Drug Discovery & Achievement Award
3. Profil Institute Appoints Dan Bradbury, former Amylin Pharmaceutical CEO, to Board of Directors
4. Scripps Research announces research & license agreement with Janssen Pharmaceuticals
5. Ben-Gurion U. researchers and Teva Pharmaceutical Industries Ltd. develop psoriasis drug
6. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
7. Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
8. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
9. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
10. Global Biotech and Pharmaceutical Conference Early Bird Registration Discounts End This Week
11. Conatus Pharmaceuticals Appoints Mark F. Morris as Head of Biostatistics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
(Date:3/21/2016)... Massachusetts , March 22, 2016 ... facial recognition with passcodes for superior security   ... ), a leading provider of secure digital communications services, ... their biometric technology and offer enterprise customers, particularly those ... secure facial recognition and voice authentication within a mobile ...
(Date:3/15/2016)... Yissum Research Development Company of the ... the Hebrew University, announced today the formation of ... various human biological indicators. Neteera Technologies has completed its ... investors. ... electromagnetic emissions from sweat ducts, enables reliable and speedy ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... IN (PRWEB) , ... May 31, 2016 , ... The ... Model Aviation Museum that will be on display Memorial Day through Labor Day 2016. ... Henry Chaffee, and Clark Chaffee. , Bill Chaffee won first place for Senior ...
(Date:5/27/2016)... New Jersey and ... Indegene ( http://www.indegene.com ... und marketingorientierten Lösungen für die Life-Science-Branche, Pharmaunternehmen ... ein bekannter weltweiter Anbieter von innovativen wissenschaftlichen ... Zuge des Starts von IntraScience heute den ...
(Date:5/26/2016)... , May 26, 2016 Despite the ... value in this space. Today,s pre-market research on ActiveWallSt.com directs ... Health Inc. (NASDAQ: RDUS ), Cerus Corp. (NASDAQ: ... ARWR ), and Five Prime Therapeutics Inc. (NASDAQ: ... briefings at: http://www.activewallst.com/ On ...
(Date:5/25/2016)... ... May 25, 2016 , ... Thailand’s Board ... BIO 2016 in San Francisco. Located at booth number 7301, representatives from the ... questions and discuss the Thai biotechnology and life sciences sector. , Deputy ...
Breaking Biology Technology: