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Offering hope for tissue regeneration
Date:2/26/2010

ship in oncology and is director of the division of hematology/oncology at Alpert Medical School.

Among the practical implications from their findings is an understanding of the mechanism of tissue repair and determining whether or not microvesicles can be used in a therapeutic fashion. Aliotta explains, "If you have an injured organ, our hope is that if we were to deliver large numbers of microvesicles to that injured organ, it would help the repair process."

Based on their findings, the researchers also hypothesize that microvesicles could potentially be mediators of cancer metastasis. It is known that in cancer there are higher levels of circulating microvesicles, and these microvesicles may be responsible for transferring the traits of the cancer to other organs. Aliotta notes, "If we can define the microvesicles that are shed from cancer cells, we can identify unique characteristics, which might help us to block their uptake into normal cells. This could, in theory, stop the metastasis of cancer."

Quesenberry concludes, "Our work explained in this paper and the work still to come from our COBRE grant hold great promise in terms of future treatment of tissue repair and cancer."


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Contact: Nancy Jean
njean@lifespan.org
Lifespan
Source:Eurekalert

Page: 1 2 3

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