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Of mice and men: UNC-led team solves mouse genome dilemma
Date:5/29/2011

their genome and captures less than 20 percent of the diversity of the entire mouse genome. Historically, biomedical researchers have relied on what are called classical inbred strains of mice in laboratory research. With the advance of genetic science, researchers began to use wild-derived laboratory strains (descendants of captured wild mice that originate from a small number of original ancestors) to try to overcome issues associated with limited genetic diversity. However, scientists' understanding of genetic diversity in mice has until now been limited and biased toward the most frequently used strains.

The team compared the genome of a large and diverse sample including 36 strains of wild-caught mice, 62 wild-derived laboratory strains and 100 classical strains obtained from different stocks and different laboratories using the Mouse Diversity array a technology that maps the entire mouse genome.

Their analysis exponentially increases the data available to geneticists who work with mice, allowing them to statistically impute the whole mouse genome sequence with very high accuracy for hundreds of laboratory mouse strains leading to much greater precision in the interpretation of existing biomedical data and optimal selection of strains in future experiments.


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Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

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