Navigation Links
Odor receptors discovered in lungs
Date:1/2/2014

Your nose is not the only organ in your body that can sense cigarette smoke wafting through the air. Scientists at Washington University in St. Louis and the University of Iowa have showed that your lungs have odor receptors as well.

Unlike the receptors in your nose, which are located in the membranes of nerve cells, the ones in your lungs are in the membranes of neuroendocrine cells. Instead of sending nerve impulses to your brain that allow it to "perceive" the acrid smell of a burning cigarette somewhere in the vicinity, they trigger the flask-shaped neuroendocrine cells to dump hormones that make your airways constrict.

The newly discovered class of cells expressing olfactory receptors in human airways, called pulmonary neuroendocrine cells, or PNECs, were found by a team led by Yehuda Ben-Sharar, PhD, assistant professor of biology and medicine at Washington University in St. Louis, and including colleagues Steven L. Brody and Michael J. Holtzman of the Washington University School of Medicine, and Michel J. Welsh of the Lucille A. Carver College of Medicine at the University of Iowa.

"We forget," said Ben-Shahar, "that our body plan is a tube within a tube, so our lungs and our gut are open to the external environment. Although they're inside us, they're actually part of our external layer. So they constantly suffer environmental insults," he said, "and it makes sense that we evolved mechanisms to protect ourselves."

In other words, the PNECs, described in the March issue of the American Journal of Respiratory Cell and Molecular Biology, are sentinels, guards whose job it is to exclude irritating or toxic chemicals.

The cells might be responsible for the chemical hypersensitivity that characterizes respiratory diseases, such chronic obstructive pulmonary disease (COPD), and asthma. Patients with these diseases are told to avoid traffic fumes, pungent odors, perfumes and similar irritants, which can trig
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Extensive variability in olfactory receptors influences human odor perception
2. Researchers use nanoscale patches to sensitize targeted cell receptors
3. Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
4. Describing biodiversity on tight budgets: 3 new Andean lizards discovered
5. Missing molecule in chemical production line discovered
6. Europes rarest orchid rediscovered on lost world volcano in the Azores
7. New long-lived greenhouse gas discovered by University of Toronto chemistry team
8. Newly discovered human peptide may become a new treatment for diabetes
9. New dinosaur discovered in Utah
10. Fossil of new big cat species discovered; oldest ever found
11. Northeastern researchers have discovered a new treatment to cure MRSA infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Odor receptors discovered in lungs
(Date:7/24/2014)... 2014 /PRNewswire-iReach/ -- The Geneva Healthcare Suite, an innovative ... cut emergency room wait times by an average of ... Center, according to a recent study published in the ... using the suite to access data from incoming patients, ... "Using Geneva,s technology platform we have been able ...
(Date:7/24/2014)... by 45% on average over a 35 year period ... on the impact of humans on declining animal numbers. ... such as insects, spiders, crustaceans, slugs and worms bring ... for crops, decomposition for nutrient cycling, water filtration and ... and led by UCL, Stanford and UCSB, focused ...
(Date:7/24/2014)... Imagine a smog-free Los Angeles, where electric cars ply ... run on heat from beneath the earth, from howling ... new Stanford study finds that it is technically and ... one powered by clean, renewable energy. Published in ... sustainable, inexpensive and reliable energy supply in California that ...
Breaking Biology News(10 mins):UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4
... is showing multiple benefits from restoration efforts, newly published ... increased the abundance and diversity of submerged aquatic vegetation ... during the 18-year field study. Since 1990, the ... doubled, the area covered by native SAV has increased ...
... prominent speakers have been added to the slate ... Military Medicine Symposium: Advancing Public-Private Partnerships, on September ... Washington, D.C. The event is a premier opportunity ... to come together to discuss medical partnerships to ...
... than a health hazard according to scientists from The University ... Medicine and Science have discovered powerful antibiotic properties in the ... treatments for multi-drug resistant bacterial infections. They found that the ... were able to kill more than 90 per cent of ...
Cached Biology News:Potomac River: 10-fold increase in native submerged vegetation reflects improved water quality 2Sutherland and Berglass to keynote USU-HJF Military Medicine Symposium 2Sutherland and Berglass to keynote USU-HJF Military Medicine Symposium 3Cockroach brains could be rich stores of new antibiotics 2
(Date:7/24/2014)...  Now available is a stem cell therapy that ... , located in Guadalajara, Mexico , ... new health option: stem cell therapies for sports ... suffer from joint and muscle injuries due to professional ... rotator cuff, tennis elbow, and knee injuries. Throughout life ...
(Date:7/24/2014)... , July 24, 2014  ECC West Africa, ... Colorado with University College Hospital (UCH) Ibadan ... development project to finance, design, construct, and operate and ... Nigeria . Under the first of the ... scoping documents and funding applications. UCH Ibadan intends to ...
(Date:7/24/2014)... leader Yung-Eun Sung has announced that they have ... graphenes which can be applied as high performance ... Sung is both a group leader at the ... Science* (IBS) and a professor at the Seoul ... with regards to the development of relative simplicity, ...
(Date:7/24/2014)... of Engineering at the University of Delaware, is ... in energy engineering, environmental sustainability and electronics. , ... rock with a well-defined, crystalline structure. At the ... decided that zeolites can separate molecules with size ... (one-tenth of a nanometer), making them useful to ...
Breaking Biology Technology:Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2University of Delaware researcher describes new approach for creating organic zeolites 2
... than a year after Chippewa Valley Technical College ... Administration has approved a $1.5 million grant to help ... ,The grant will cover part of the cost of ... create an estimated 650 jobs and generate $30 million ...
... Day birthing of new products, or simply the last rush to ... busy day for product news. In fact, two DEMO alumni - ... - are delivering significant new functionality to their faithful customers. ... smart phone. The newest member of the Treo family is based ...
... - By several measures, these should be heady days ... manufacturing jobs were lost, the economy is back, manufacturing revenue ... there is a sense of unease linked to withering competitive ... of what their American counterparts earn, where manufacturers have a ...
Cached Biology Technology:Two DEMO alumni make big product splashes 2Two DEMO alumni make big product splashes 3Manufacturers advised to redesign customer relations 2Manufacturers advised to redesign customer relations 3
... The Zero Blunt ... for Sequencing is designed ... sequencing of blunt-end PCR ... provides 5-minute TOPO Cloning ...
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
One-step, microplate or cuvet, colorimetric, detection range 0.78 ug/dL to 65 ug/dL Zn in serum, plasma, urine, saliva etc. Procedure: 10 min....
Biology Products: