Navigation Links
Odd protein interaction guides development of olfactory system
Date:10/29/2007

Scientists have discovered a strange mechanism for the development of the fruit fly antennal lobe, an intricate structure that converts the chaotic stew of odors in the environment into discrete signals in the brain.

The fruit fly antennal lobe is analogous to the olfactory bulb in humans.

Researchers at the University of Illinois found that in the flys antennal lobe a common nervous system receptor actually inhibits the activity of the protein it binds. This is the first time a receptor has been found to behave this way in normal, healthy cells.

The study appears this month in Nature Neuroscience.

Receptors and the proteins that bind to them normally work in concert to generate a cascade of changes within cells. A receptor may be embedded in the cell membrane, waiting for a specific protein, called a ligand, to bind to it. Binding often causes the receptor to change its shape, allowing it to interact with other components in the cell. These reactions continue until a specific task is accomplished. Receptors and ligands are fundamental to most chemical signaling in the body, and normally they work together.

The new mechanism, which directs the growth and development of tens of thousands of neurons that are vital to odor detection, instead involves a receptor that disables its protein ligand. The receptor is called derailed because its absence causes neurons to grow wildly off-track. The ligand that binds to the derailed receptor is known as Wnt5 (pronounced wint 5 short for wingless insertion 5). Both derailed and Wnt5 are known to play key roles in the growth and development of the nervous system.

In the antennal lobe, derailed is acting as a decoy receptor, said U. of I. cell and developmental biology professor Huey Hing, who led the study.

It is nonproductively just sucking up the ligand. Nobody has ever seen a receptor acting in this way. The receptor is actually regulating the ligand.


'/>"/>
Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign  
Source:Eurekalert

Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. New, automated tool successfully classifies and relates proteins in unprecedented way
4. New binding target for oncogenic viral protein
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Timing is everything: First step in protein building revealed
7. UWs Rosetta software to unlock secrets of many human proteins
8. Researchers find how protein allows insects to detect and respond to pheromones
9. Researchers Uncover Key Step In Manufacture of Memory Protein
10. Signaling protein builds bigger, better bones in mice
11. Ancient olfaction protein is shared by many bugs, offering new pest control target
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Odd protein interaction guides development of olfactory system
(Date:9/23/2014)... majority of drugs used to treat asthma today are the ... are urgently needed to treat this chronic respiratory disease, which ... to wheeze, cough, and find it difficult at best to ... is tough: asthma is a patient-specific disease, so what works ... animal models traditionally used to test new drug candidates often ...
(Date:9/23/2014)... , 23 de septiembre de 2014 ... del Sistema 1290 Infinity II LC, el ... Infinity en su portafolio de cromatografía líquida. ... y directores de laboratorio que alcancen nuevos ... facilidad de uso y capacidad de integración ...
(Date:9/23/2014)... Most organisms, including humans, have parasitic DNA fragments called ... genetic instructions in the process. And that phenomenon can ... at the University of Rochester now report that the ... age when a multi-function protein stops keeping them in ... , In a study published today in Nature ...
Breaking Biology News(10 mins):Airway muscle-on-a-chip mimics asthma 2Airway muscle-on-a-chip mimics asthma 3Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 2Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 3A multi-function protein is key to stopping genomic parasites from 'jumping' 2
... Internal Identity Theft Research Uncovers New Fraud Behavior ... Analytics, Inc., the leader in,on- demand identity intelligence, ... theft study which provides an unprecedented,analysis of the ... stolen from the workplace by employees. The study,s ...
... York, NY In the United States, Lyme disease ... passed from animals to humans. These animal-borne diseases can ... outbreaks and effective intervention are crucial to protecting the ... in Millbrook, NY recently received $750,000 in grant funding ...
... microbes in the soil break down fallen plant matter, a ... and the normal release of the greenhouse gas carbon dioxide ... stems and twigs, this organic matter slowly becomes part of ... by bacteria and other microbes. This process adds plant nutrients ...
Cached Biology News:ID Analytics Study Reveals Employees' Criminal Misuse of Stolen Identities 2ID Analytics Study Reveals Employees' Criminal Misuse of Stolen Identities 3ID Analytics Study Reveals Employees' Criminal Misuse of Stolen Identities 4EPA funds ground-breaking Lyme disease research 2Microbe diet key to carbon dioxide release 2Microbe diet key to carbon dioxide release 3
(Date:9/23/2014)... News Facts , As ... devoted to genome-based research for human health and disease, the ... a bite out of oral cancer with its world-class research ... India with the help of state-of-the-art solution comprising ... , To fuel its cutting-edge cancer research, the institute ...
(Date:9/23/2014)... Mass. , Sept. 23, 2014   GenoSpace ... a comprehensive suite of tools to enable the broad ... today announced that it has been awarded Phase I ... (SBIR) from the National Institutes of Health (NIH) to ... Logo - http://photos.prnewswire.com/prnh/20140922/147649 ...
(Date:9/23/2014)... SC (PRWEB) September 23, 2014 Dr. ... my third book on healthcare offers a three phase ... 21st century healthcare delivery system that would go far ... state’s responsibility regarding the delivery of healthcare.” , “Every ... safety has failed to provide discernable progress throughout that ...
(Date:9/22/2014)... treated with a statin in the hospital after suffering ... survive than those who were not, according to a ... study was conducted by the same researchers who recently ... survival in victims of ischemic stroke., Ischemic stroke is ... vessel that blocks blood from reaching areas of the ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5GenoSpace Awarded Fast Track SBIR Grant to Enable Data Access and Cohort Construction for Biorepositories 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2
... 17 Initial public offerings for LinkedIn and Dunkin Donuts, takeovers of Mead Johnson Nutrition and Harley-Davidson, and a Cold Stone Creamery sale are among the 10 deals predicted by ... ... ... ...
... , March 17 Valeritas, Inc., a medical technology company committed to the development and commercialization of innovative drug delivery solutions, announced today that it has hired James ... ... ... ...
... ... Converting to 3D Imaging , ... Thornwood, N.Y. (PRWEB) March 17, 2010 -- Carl Zeiss, a leading provider ... recently announced two exciting online promotions. For a limited time, and only available online, ...
Cached Biology Technology:From Donuts To Hogs - Which Brand Icons Might Be In Play? 2From Donuts To Hogs - Which Brand Icons Might Be In Play? 3From Donuts To Hogs - Which Brand Icons Might Be In Play? 4From Donuts To Hogs - Which Brand Icons Might Be In Play? 5From Donuts To Hogs - Which Brand Icons Might Be In Play? 6From Donuts To Hogs - Which Brand Icons Might Be In Play? 7From Donuts To Hogs - Which Brand Icons Might Be In Play? 8Valeritas Announces Appointment of New CFO 2Valeritas Announces Appointment of New CFO 3Carl Zeiss Offers Online Promotions 2
...
Monoclonal Mouse Anti-Human Cytokeratin 16 (48 kD)...
This antibody detects cdc42 on SDS-PAGE immunoblots....
Goat polyclonal to Nebraska Calf Diarrhea Virus (FITC) ( Abpromise for all tested applications). Antigen: Bovine (Nebraska Calf Diarrhea Virus)....
Biology Products: