Navigation Links
Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB
Date:4/1/2009

LONDON and SAN DIEGO, April 2, 2009 University College London Business PLC (UCLB) and Ocera Therapeutics Inc., a privately held biopharmaceutical company, announced the signing of an exclusive worldwide licensing agreement for UCL-L1V and all assets and technologies related to the compound for the treatment of acute hepatic encephalopathy (AHE).

The compound recently demonstrated that it directly reduces blood levels of ammonia, a highly toxic chemical that builds up during attacks of AHE.

Ocera will develop the licensed compound as its second pipeline compound and refer to it as OCR-002. OCR-002 is a novel injectable for the treatment of AHE in patients with advanced liver cirrhosis and acute liver failure.

The licensing agreement is based on research conducted by the collaborative global research project led by Professor Rajiv Jalan and the Liver Failure Group at the Institute of Hepatology, UCL (University College London). The research includes a study which demonstrated an acute and sustained reduction of systemic ammonia levels as well as decreased intracranial pressure in models of AHE in acute liver failure and cirrhosis. The data was published online in Hepatology in February 2009.

Clinical trials in patients with AHE due to cirrhosis and acute liver failure will be carried out at University College Hospital as well as other centres in 2009 under funding from the Medical Research Council (MRC) in the U.K. Ocera is planning to file an IND in late 2009 and U.S. trials will begin in early 2010.

AHE is a reversible neuropsychiatric abnormality frequently seen as a complication of acute liver failure and cirrhosis. With severe liver impairment, toxic substances such as ammonia that are normally removed by the liver accumulate in the blood and impair the function of brain cells.

Signs of AHE include impaired cognition, uncontrolled movements and decreased levels of consciousness leading to
'/>"/>

Contact: Ruth Metcalfe
r.metcalfe@gmail.com
44-020-767-99739
University College London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Tufts University professor receives IADR Pharmacology/Therapeutics/Toxicology Award
2. Acorda Therapeutics submits new drug application for Fampridine-SR in multiple sclerosis
3. A novel target for therapeutics against Staph infection
4. Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration
5. Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics
6. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
7. Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics
8. CU-Boulder, biotech firm team up on python project in search for human cardiac therapeutics
9. Michael J. Fox Foundation PD Therapeutics Conference
10. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
11. Syntermed licenses Emory ERTb software for enhanced cardiac imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... have built the first smartphone app that automatically ... trends. In other words, your smartphone knows your ... -- and how that affects you. , The ... and loneliness to their academic performance, also may ... example, to monitor mental health, trigger intervention and ...
(Date:9/18/2014)... several disciplines will be celebrated tonight at the third ... improving the health of premature infants and in paving ... researchers, whose work was supported by the National Science ... Atomic Energy Commission, will be honored at a ceremony ... bipartisan group of Members of Congress will be on ...
(Date:9/18/2014)... Why is it that when people are too stressed ... Researchers from the Brain Mind Institute (BMI) at EPFL ... the relationship between chronic stress and the loss of ... an enzyme attacks a synaptic regulatory molecule in the ... Nature Communications . , Carmen Sandi,s team ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 43rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2How stress tears us apart 2
... of Genes & Development, Dr. Karlene Cimprich and colleagues ... sufficient to activate the ATR-mediated DNA damage checkpoint. ... Dr. Cimprich. "The ability to precisely define and manipulate ... experimental system will enable us to control, quantitative and ...
... to preserve grapes could help prevent allergies and boost healthy ... & Industry, the magazine of the SCI. The same technique ... wines without the added sulphites that can cause asthma and ... remain in storage for months and are usually treated with ...
... knowledge of the properties and actions of enzymes, scientists have ... originally isolated from blue-green algae. , This accomplishment is ... promising drugs for use in clinical trials. , In ... of the journal ACS Chemical Biology, a scientific team lead ...
Cached Biology News:Grape expectations for healthier wine 2Turning green gunk to gold, anti-cancer gold 2
(Date:9/18/2014)... (PRWEB) September 18, 2014 ... urological and interventional radiology products and services, announced ... as cryotherapy and cryoablation) versus external beam radiotherapy ... of the American Urological Association (MAAUA) Annual Meeting ... "Comparing Relative Effectiveness of Cryosurgery and External Beam ...
(Date:9/18/2014)... Ireland , September 18, 2014 ... and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has ... "Biocompatible Materials - Global Strategic Business ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes ... in US$ Million by the following ...
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global Human Albumin Industry Report 2014" report to ... Industry Report 2014 is a professional and in-depth study ... industry. The report provides a basic overview ... chain structure. The human albumin market analysis is provided ...
(Date:9/18/2014)... Sept. 18, 2014  Neogen Corporation (Nasdaq: ... a strategic agreement with Merck Animal Health to market ... The Igenity Dairy Heifer Program consists of genomic ... the genetic potential of replacement dairy heifers. The genomic ... born, and is an excellent tool in the decision-making ...
Breaking Biology Technology:HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Merck Animal Health to market Neogen's dairy genomic program 2
... in Life Sciences Technology Sector, TROY, Mich., ... association, will release key data from its,Fourth Annual ... State of Technology Luncheon on Wednesday, Nov. 12 ... Anderson Economic Group,provides data regarding Automation Alley,s rapidly ...
... of transport of key amyloid marker from ... Nov. 10 /PRNewswire-FirstCall/ - Resverlogix Corp.,("Resverlogix") (TSX:RVX) announced ... first in class ApoA-I/Prebeta-HDL elevating drug, in a ... that treatment with RVX-208,resulted in a positive trend ...
... 10 GeoVax Labs, Inc. (OTC,Bulletin Board: GOVX) ... vaccines for diseases caused by HIV-1 (Human,Immunodeficiency Virus) ... 2008 financial results and provided an operational update., ... "We are very,pleased with the progress we,ve made ...
Cached Biology Technology:Automation Alley Releases Report on State of Southeast Michigan's Technology Economy 2Automation Alley Releases Report on State of Southeast Michigan's Technology Economy 3RVX-208 Exploratory Study Illustrates Early Potential for Alzheimer's Disease 2RVX-208 Exploratory Study Illustrates Early Potential for Alzheimer's Disease 3RVX-208 Exploratory Study Illustrates Early Potential for Alzheimer's Disease 4GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 2GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 3GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 4GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 5GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 6GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 7GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 8GeoVax Labs, Inc. Announces Third Quarter 2008 Financial Results and Provides Operational Update 9
EZ-DeWax is a one-step solution that simultanously removes paraffin from and rehydrates formalin-fixed, paraffin embedded tissue...
Artisan™ Wash Solution (x 50) Additional Information: EU regulatory status: CE US regulatory status: IVD ...
... is an inexpensive personal or mini thermal cycler, ... Lightweight, with a small footprint, it can be ... researcher's desk. , The Gene Cycler thermal cycler ... have access to a large laboratory thermal cycler, ...
... Secondary Detection System is intended for use ... Antibody reagents, which contain rat and goat ... by light microscopy in paraffin-embedded tissues. The ... also be used with other rat or ...
Biology Products: