Navigation Links
Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB
Date:4/1/2009

LONDON and SAN DIEGO, April 2, 2009 University College London Business PLC (UCLB) and Ocera Therapeutics Inc., a privately held biopharmaceutical company, announced the signing of an exclusive worldwide licensing agreement for UCL-L1V and all assets and technologies related to the compound for the treatment of acute hepatic encephalopathy (AHE).

The compound recently demonstrated that it directly reduces blood levels of ammonia, a highly toxic chemical that builds up during attacks of AHE.

Ocera will develop the licensed compound as its second pipeline compound and refer to it as OCR-002. OCR-002 is a novel injectable for the treatment of AHE in patients with advanced liver cirrhosis and acute liver failure.

The licensing agreement is based on research conducted by the collaborative global research project led by Professor Rajiv Jalan and the Liver Failure Group at the Institute of Hepatology, UCL (University College London). The research includes a study which demonstrated an acute and sustained reduction of systemic ammonia levels as well as decreased intracranial pressure in models of AHE in acute liver failure and cirrhosis. The data was published online in Hepatology in February 2009.

Clinical trials in patients with AHE due to cirrhosis and acute liver failure will be carried out at University College Hospital as well as other centres in 2009 under funding from the Medical Research Council (MRC) in the U.K. Ocera is planning to file an IND in late 2009 and U.S. trials will begin in early 2010.

AHE is a reversible neuropsychiatric abnormality frequently seen as a complication of acute liver failure and cirrhosis. With severe liver impairment, toxic substances such as ammonia that are normally removed by the liver accumulate in the blood and impair the function of brain cells.

Signs of AHE include impaired cognition, uncontrolled movements and decreased levels of consciousness leading to
'/>"/>

Contact: Ruth Metcalfe
r.metcalfe@gmail.com
44-020-767-99739
University College London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Tufts University professor receives IADR Pharmacology/Therapeutics/Toxicology Award
2. Acorda Therapeutics submits new drug application for Fampridine-SR in multiple sclerosis
3. A novel target for therapeutics against Staph infection
4. Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration
5. Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics
6. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
7. Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics
8. CU-Boulder, biotech firm team up on python project in search for human cardiac therapeutics
9. Michael J. Fox Foundation PD Therapeutics Conference
10. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
11. Syntermed licenses Emory ERTb software for enhanced cardiac imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... July 24, 2014 Pfenex Inc. (NYSE MKT: PFNX) ... 8,333,333 shares of its common stock at a price to ... granted the underwriters a 30-day option to purchase up to ... offering price. The shares are expected to begin trading on ... "PFNX". William Blair & Company, L.L.C. ...
(Date:7/23/2014)... The U.S. Environmental Protection Agency (EPA) today ... the University of Massachusetts Amherst School of Public ... three-year, $700,000 Science to Achieve Results (STAR) grant ... by Native subsistence hunters in subarctic North America ... exposure and to provide culturally-relevant recommendations for mitigation. ...
(Date:7/23/2014)... State University shows that urban "heat islands" are slowly ... factor is that researchers have found warmer temperatures increase ... insect a significant tree pest by 300 ... adult gloomy scales on urban trees. , "We,d been ... scale in cities, and now we know why," says ...
Breaking Biology News(10 mins):Pfenex Inc. Announces Pricing Of Initial Public Offering 2Studying impacts of indoor air pollution on tribal communities 2Studying impacts of indoor air pollution on tribal communities 3Urban heat boosts some pest populations 200-fold, killing red maples 2Urban heat boosts some pest populations 200-fold, killing red maples 3
... lot of variables come into play when selecting a site ... as wildlife needs, species and vegetation uniqueness, and costs to ... of Illinois researchers found that society and the environment ... are closer to people because people are more willing to ...
... Chemists and biologists have successfully demonstrated that specially synthesized ... a move that, they say, is a proof of ... In June 2008, University of Oregon chemist Shih-Yuan ... Chemical Society his lab,s synthesis of boron-nitrogen compounds ...
... Michigan are reporting the development of a powerful new probe ... in aging and disease. The probe works like a GPS ... could lead to new insights into disease processes and identify ... is scheduled for the Sept. 18 issue of ACS ...
Cached Biology News:Research recommends compromise when choosing conservation site 2Research recommends compromise when choosing conservation site 3Research recommends compromise when choosing conservation site 4Boron-based compounds trick a biomedical protein 2
(Date:7/23/2014)... 23, 2014 DuPont Pioneer announced today ... vice president of Agricultural Biotechnology (ABT), effective July 21, ... served most recently as president, chief executive officer and ... leadership in the seed and crop protection industry to ... E. Schickler , president of DuPont Pioneer. “I am ...
(Date:7/23/2014)... 23, 2014 regulated information -- UCB today announced ... pipeline with positive topline results from the latest ... was designed to evaluate the efficacy and safety ... without titration) compared to placebo, as adjunctive treatment ... not fully controlled despite treatment with one or ...
(Date:7/23/2014)... , July 23, 2014  GrowBLOX Sciences, Inc. (OTCQB: GBLX), ... it is filing for two medical marijuana dispensary locations in ... in addition to the Clark County, Nevada ... use permit, as previously announced.  GrowBLOX Sciences, CEO ... submitting two new applications for dispensaries in the ...
(Date:7/23/2014)... KONG , July 23, 2014 China Cord Blood ... China,s leading provider of cord blood collection, laboratory ... Cordlife Group Limited ("Cordlife"), a multi-product healthcare company catering to the ... joined forces in assisting patients across the PRC, Singapore ... , India , the Philippines ...
Breaking Biology Technology:DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 2China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 3China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 4
... About 18 months ago, I sat with the product managers at ... were the $99 devices intended to be an entry-level digital organizer ... Shack and Target and wanted a simple product that delivered real ... a quick test drive, I leaned close to the product marketing ...
... Middleton, Wis. Standard Imaging , a Middleton-based ... treatment for cancer cardiology and other applications, has announced ... the assets acquired from the British Columbia-based company are ... with most electronic portal imaging devices (EPIDs). The PIPSpro ...
... The Wisconsin Alumni Research Foundation is suing ... computer memory chips, for allegedly using a patented technology developed ... in their semiconductors. , ,According to Andy Cohn, spokesman for ... is the same as previous legal actions against Sony ...
Cached Biology Technology:The Palm to "de-Zire" 2The Palm to "de-Zire" 3Standard Imaging acquires Canadian PIPSpro radiation treatment technologies 2WARF sues Samsung over computer chip technology license agreement 2
SHEEP ANTI ESCHERICHIA COLI...
Recombinant Rat Leptin, CF...
2,4,6-Trinitrophenyl hapten is conjugated to Bovine Gamma Globulin (BGG) through lysine by amide bonds....
... • Holds 0.1 mL - 25 mL pipets ... pipets. Also accommodates most standard square or round pipet ... Has four compartments, each 76 mm W x 76 ... x 11 3/8 ins.). Overall dimensions: 89 mm W ...
Biology Products: