Navigation Links
Observing live gene expression in the body
Date:6/30/2013

long with Jean-Pierre Wolf's and Luigi Bonacina's teams from UNIGE's Group of Applied Physics, was thus essential. These scientists developed a customized device that can accommodate mice for several months: 'We equipped it with reflective walls to deflect photons toward a highly sensitive photomultiplier tube to capture bioluminescence,' says Andr Liani.

Follow the daily expression of clock genes live

In collaboration with the University of Ulm and the Center for Integrative Genomics (CIG) of Lausanne, the biologists studied how the central clock synchronizes subordinate oscillators in mice. Various clock genes, coupled with the luciferase gene for light emission, were inserted into liver cells using a molecular vector. The time these rodents spent in the bioluminescent device allowed to demonstrate that the central clock generates signals, some of which act directly on the liver oscillators, and others which synchronize them indirectly by controlling the cycles of food intake.

or the effect of a medication in mice

'This technology enables a drastic reduction in the number of mice needed for this type of experiment, and furthermore, it is applicable to many areas of biomedical research,' says Camille Saini, researcher in the Department of Molecular Biology at UNIGE and first author of this article. These complementary genetic and engineering technology tools could be used to directly follow certain biochemical effects of metabolites like cholesterol or glucose, as well as the response to potential treatments of diseases such as hypercholesterolemia or diabetes. Monitoring the response to various hormones, neurotransmitters and other biochemical messengers is also part of this application range.


'/>"/>

Contact: Ueli Schibler
ueli.schibler@unige.ch
41-223-796-175
Universit de Genve
Source:Eurekalert

Page: 1 2

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. A new application allows online statistical analysis of gene-expression data
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. Fish show autism-like gene expression in water with psychoactive pharmaceuticals
5. Controlling gene expression with hydrogen peroxide switches
6. Molecular economics: New computer models calculate systems-wide costs of gene expression
7. Controlling gene expression: How chromatin remodelers block a histone pass
8. Study finds how BPA affects gene expression, anxiety; Soy mitigates effects
9. Nutrient in eggs and meat may influence gene expression from infancy to adulthood
10. Whitehead scientists identify major flaw in standard approach to global gene expression analysis
11. Oxidative stress and altered gene expression occurs in a metabolic liver disease model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... Fla. , Dec. 3, 2014  Crossmatch™, ... today announced that its DigitalPersona ® Pro ... readers have been deployed throughout First Bank branch ... South Carolina and Virginia. First ... Southern Pines, North Carolina , ...
(Date:12/3/2014)... As part of our commitment to offering ... to announce the release of a new reader that ... workforce data that they need. The Atlas ... existing readers. Many such devices have serious shortcomings when ... Older models force users to navigate numerous complicated steps ...
(Date:11/21/2014)... Nov. 19, 2014  Earlier this year Donald ... College, and one of the most prolific inventors in ... are transmitted from Smartphones to third party agencies. Spector ... has one of the earliest known patents in this ... in the military, child care, elder care and hospital ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Inception Technologies to Release New Biometric Reader 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... Rochelle, NY, December 12, 2012ExxonMobil and many other ... dollars to develop transportation biofuels from renewable resources ... microalgae. As global supplies of fossil fuels continue ... promising source of low-cost, scalable renewable energy. The ...
... painstaking effort to create a biocompatible patch to heal infant ... Hospital. The proof is in a petri dish in ... beats with the rhythm of a living heart. Jacot, ... their tissue-engineering colleagues have published the results ofyears of effort ...
... Springer and the Italian Society for Ultrasound in Medicine and ... the Journal of Ultrasound , starting in 2013 with ... is the official journal of SIUMB. It will be available ... formerly published by Elsevier. The Journal of Ultrasound ...
Cached Biology News:Can algae-derived oils support large-scale, low-cost biofuels production? 2Rice, Texas Children's team creates biocompatible patch to heal infants with birth defects 2Rice, Texas Children's team creates biocompatible patch to heal infants with birth defects 3Springer will collaborate with the Italian Society for Ultrasound in Medicine and Biology 2
(Date:12/17/2014)... 17, 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... acquisition, development and commercialization of innovative therapeutics addressing cancer ... with a primary commercial focus on China ... a Type C meeting with the U.S. Food and ... held in February 2015.  During this meeting the Company ...
(Date:12/15/2014)... Israel , Dec. 15, 2014  BrainStorm ... leading developer of adult stem cell technologies for neurodegenerative ... Ltd. was awarded a grant of approximately $1.1 million ... Chief Scientist (OCS).  This is the eighth year that ... the Office of the Chief Scientist, which is part ...
(Date:12/15/2014)... COPENHAGEN, Denmark , Dec. 15, 2014 /PRNewswire/ ... its innovative TransCon technology to address significant unmet ... from its ongoing Phase 2 pediatric study to ... growth hormone deficiency, or GHD.  This interim analysis ... the anticipated total enrollment in the study, completing ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 The ... million in 2013, and is expected to grow ... 2019. , Browse through the TOC of the ... industry trends and segments, with help of various ... The global DNA Microarray market consists of instrument, ...
Breaking Biology Technology:CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 2DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 4
... INCLINE VILLAGE, Nev., Sept. 8 PDL BioPharma, ... guidance for the third quarter ended September 30, 2009 of ... third quarter of 2008. Royalty revenues are based on second ... for Synagis(R), which is marketed by MedImmune. When compared with ...
... NOVATO, Calif., Sept. 8 BioMarin Pharmaceutical Inc. (Nasdaq: ... will present a company update at the Morgan Stanley Healthcare Conference in ... , , Interested parties may access a ... the BioMarin website, www.BMRN.com . A replay of ...
... 8 Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ) announced ... failure gout will be presented at the 2009 ACR/ARHP Annual Scientific ... posters will be presented during the "Treatment and Outcome" session on ... , Chronic Use of Pegloticase: Safety ...
Cached Biology Technology:PDL BioPharma Provides Third Quarter 2009 Revenue Guidance of Approximately $71 Million 2PDL BioPharma Provides Third Quarter 2009 Revenue Guidance of Approximately $71 Million 3BioMarin to Present at the Morgan Stanley Healthcare Conference 2Multiple Abstracts Related to KRYSTEXXA(TM) Development and Treatment Failure Gout to be Presented at the 2009 ACR/ARHP Annual Scientific Meeting 2Multiple Abstracts Related to KRYSTEXXA(TM) Development and Treatment Failure Gout to be Presented at the 2009 ACR/ARHP Annual Scientific Meeting 3Multiple Abstracts Related to KRYSTEXXA(TM) Development and Treatment Failure Gout to be Presented at the 2009 ACR/ARHP Annual Scientific Meeting 4