Navigation Links
Observing live gene expression in the body
Date:6/30/2013

long with Jean-Pierre Wolf's and Luigi Bonacina's teams from UNIGE's Group of Applied Physics, was thus essential. These scientists developed a customized device that can accommodate mice for several months: 'We equipped it with reflective walls to deflect photons toward a highly sensitive photomultiplier tube to capture bioluminescence,' says Andr Liani.

Follow the daily expression of clock genes live

In collaboration with the University of Ulm and the Center for Integrative Genomics (CIG) of Lausanne, the biologists studied how the central clock synchronizes subordinate oscillators in mice. Various clock genes, coupled with the luciferase gene for light emission, were inserted into liver cells using a molecular vector. The time these rodents spent in the bioluminescent device allowed to demonstrate that the central clock generates signals, some of which act directly on the liver oscillators, and others which synchronize them indirectly by controlling the cycles of food intake.

or the effect of a medication in mice

'This technology enables a drastic reduction in the number of mice needed for this type of experiment, and furthermore, it is applicable to many areas of biomedical research,' says Camille Saini, researcher in the Department of Molecular Biology at UNIGE and first author of this article. These complementary genetic and engineering technology tools could be used to directly follow certain biochemical effects of metabolites like cholesterol or glucose, as well as the response to potential treatments of diseases such as hypercholesterolemia or diabetes. Monitoring the response to various hormones, neurotransmitters and other biochemical messengers is also part of this application range.


'/>"/>

Contact: Ueli Schibler
ueli.schibler@unige.ch
41-223-796-175
Universit de Genve
Source:Eurekalert

Page: 1 2

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. A new application allows online statistical analysis of gene-expression data
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. Fish show autism-like gene expression in water with psychoactive pharmaceuticals
5. Controlling gene expression with hydrogen peroxide switches
6. Molecular economics: New computer models calculate systems-wide costs of gene expression
7. Controlling gene expression: How chromatin remodelers block a histone pass
8. Study finds how BPA affects gene expression, anxiety; Soy mitigates effects
9. Nutrient in eggs and meat may influence gene expression from infancy to adulthood
10. Whitehead scientists identify major flaw in standard approach to global gene expression analysis
11. Oxidative stress and altered gene expression occurs in a metabolic liver disease model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... iodine-125 (125I) in cancer treatment has been shown ... are critical for neural transmission between the peripheral ... colleagues from Institute of Radiation Medicine, Chinese Academy ... be implanted into rat dorsal root ganglia (DRG) ... with different radioactivity (0, 14.8, 29.6 MBq) were ...
(Date:7/30/2014)... first high-resolution map of the carbon stocks stored ... The new and improved methodology used to make ... market-based carbon economies. The new carbon map ... it provides the critical input to studies of ... and enforcement purposes. The technique includes the determination ...
(Date:7/29/2014)... researchers sometimes need to get back to basics. ... to study the impacts of the bumphead parrotfish ... at two remote locations in the central Pacific ... computer simulation, McCauley, an assistant professor in the ... his colleagues sought to understand whether the world,s ...
Breaking Biology News(10 mins):Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3Underwater elephants 2Underwater elephants 3
... University of Illinois scientists have learned that a specific ... health. "In experiments with mice, we knocked out ... body to make arachidonic acid. Without arachidonic acid, the ... itchy, they scratched themselves continuously, and they developed a ...
... A team of researchers from the United States and Europe ... a role in the etiology of common forms of kidney ... variations in DNA sequences in more than 65,000 individuals of ... be more frequent among people with poor kidney function or ...
... Just one "pulse" of artificial light at night disrupts ... by Dr. Rachel Ben-Shlomo of the University of Haifa-Oranim ... Charalambos P. Kyriacou of the University of Leicester. "Damage ... is therefore important to understand the causes of this ...
Cached Biology News:U of I study: Lack of omega-6 fatty acid linked to severe dermatitis 2International research team discovers novel genes influencing kidney disease risk 2
(Date:7/30/2014)...  Decision Resources Group finds that the majority ... the United States believe that ... be the level of savings achievable by their ... cost to patients. Payers plan to leverage preferential ... expectations in order to encourage physician prescribing of ...
(Date:7/30/2014)... July 30, 2014  The Chicago Bears are excited ... of Dermatology (Academy) in an effort to raise awareness ... will host free SPOT me™ skin cancer screenings at ... Soldier Field. SPOT me™ is an educational campaign ... dangers and risks of skin cancer, and encourages people ...
(Date:7/30/2014)... While administrative claims and other data ... a relatively long period of time, there has ... of these ‘big data’ for comparisons of interventions ... powerful computer technology with the plethora of data ... significant promise for identifying optimal interventions for specific ...
(Date:7/30/2014)... 30, 2014 Sales Horizons, a leader ... blended sales training programs for companies engaged in complex ... used by thousands of salespeople over 25 years in ... program can be customized to address the unique sales ... blended sales training program consists of two parts: ...
Breaking Biology Technology:Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 3Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 2Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 3Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 4Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 2Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 3
... SAN FRANCISCO, Nov. 12 VIA Pharmaceuticals,(Nasdaq: ... on the development of,compounds for the treatment ... its clinical advisory board. Joining the clinical ... Professor of Medicine,Harvard Medical School, and Senior ...
... Associated with Chronic Pain Conditions in Patients Who ... ... FRAZER, Pa., Nov. 12 Cephalon, Inc. (Nasdaq:,CEPH) today announced ... Food and Drug Administration (FDA) seeking approval to,market FENTORA(R) (fentanyl buccal ...
... N.J. -- The Edwin A. Stevens Society of Stevens Institute ... School of Systems and Enterprises, Dr. Dinesh Verma, with the ... at the Park Avenue Club in Florham Park, N.J., Nov. ... is by invitation only., The Presidents Leadership Award is presented ...
Cached Biology Technology:VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 2VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 3VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 4Cephalon Submits Supplemental New Drug Application for FENTORA 2Cephalon Submits Supplemental New Drug Application for FENTORA 3Cephalon Submits Supplemental New Drug Application for FENTORA 4Cephalon Submits Supplemental New Drug Application for FENTORA 5Cephalon Submits Supplemental New Drug Application for FENTORA 6Cephalon Submits Supplemental New Drug Application for FENTORA 7Dr. Dinesh Verma to be honored with President's Leadership Award at Edwin A. Stevens Society Gala 2Dr. Dinesh Verma to be honored with President's Leadership Award at Edwin A. Stevens Society Gala 3