Navigation Links
Obesity-related hormone is higher in children with Down syndrome
Date:10/26/2007

Children with Down syndrome are more likely than their unaffected siblings to have higher levels of a hormone associated with obesity, according to pediatric researchers. The hormone, leptin, may contribute to the known higher risk of obesity among children and adults with Down syndrome.

A research team from The Childrens Hospital of Philadelphia and the University of Pennsylvania School of Medicine published their study online today in the Journal of Pediatrics.

The researchers studied 35 children with Down syndrome and 33 of their siblings. All of the children were between the ages of four and 10, and were from the Philadelphia area. The researchers intentionally did not include severely obese children in the study, in order to focus on risk factors for obesity before obesity occurred.

The children with Down syndrome had significantly higher body mass index, a higher percentage of body fat, and higher levels of leptin compared to their siblings. The higher leptin levels persisted even when the researchers adjusted for the effect of percentages of body fat, suggesting that differences in body composition did not account for the difference in leptin levels.

The normal role of leptin is to suppress appetite and regulate body weight, said senior author Nicolas Stettler, M.D., MSCE, a pediatric nutrition specialist at The Children's Hospital of Philadelphia. In general, obese people have higher levels of leptin, which suggests that they have some leptin resistancetheir bodies do not respond to the hormone properly. Because Down syndrome is a chromosome disorder, children with Down syndrome may have a genetic predisposition to more severe leptin resistance.

Sheela N. Magge, M.D., M.S.C.E., a pediatric endocrinologist at Childrens Hospital, the first author of the study, stressed that more research remains to be done on this question, as the reasons are yet uncertain why patients with Down syndrome are at higher risk of obesity. Although the study had an advantage in including siblings as a control group, because this decreases the influence of different environments on children with or without Down syndrome, the sample size was limited, so larger studies are necessary. However, our findings may point to a useful approach to understanding why obesity often occurs in Down syndrome.


'/>"/>

Contact: Joey Marie McCool
McCool@email.chop.edu
267-426-6070
Children's Hospital of Philadelphia
Source:Eurekalert

Related biology news :

1. Female sex hormones play a vital role in defense against sexually transmitted diseases
2. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
3. Measuring hormone cuts antibiotic use in half in pneumonia patients
4. Alcohol consumption disrupts breastfeeding hormones
5. VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Penguin chicks exposed to human visitors experience spike in stress hormone
8. Hormones and growth: The control of body size and developmental growth rate in fruit flies
9. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
10. Suppressing growth hormone in early adulthood may prevent cancer
11. Growth hormone is made in the brain, report scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:3/31/2016)... PROVIDENCE, R.I. , March 31, 2016  Genomics ... leadership of founding CEO, Barrett Bready , M.D., ... addition, members of the original technical leadership team, including ... Vice President of Product Development, Steve Nurnberg and Vice ... have returned to the company. Dr. Bready ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... 27, 2016 , ... Weeks after hosting a carpal tunnel syndrome workshop with ... surgeon and founder of the Fitzmaurice Hand Institute, has announced the addition of MRI ... state-of-the-art technology and only 1 of about 3 currently available in the United States. ...
(Date:5/26/2016)... Mich. , May 26, 2016  Agriculture nutrients ... Des Moines, Iowa is running their ... Lake Erie and coastal regions ... key to preventing this widespread issue. NECi ... Upper Peninsula, developed a new, easy to ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... company, today announced several positive developments that position the Company for the future. ... of the transaction, Craig F. Kinghorn has been appointed Chairman of the Board, ...
(Date:5/25/2016)... ... 25, 2016 , ... Founder of the Fitzmaurice Hand Institute ... surgery of the hand by the National Board of Physicians and Surgeons, as ... beyond in his pursuit of providing the most comprehensive, effective treatment for his ...
Breaking Biology Technology: