Navigation Links
Obesity genes revealed
Date:8/10/2008

A study of 228 women has revealed genetic variants responsible for body shape. Based on work in the fruit fly Drosophila melanogaster, research published today in the open access journal BMC Genetics identifies natural variation in the human LAMA5 gene as a key determinant of weight.

As the prevalence of obesity and related health problems continues to increase worldwide, there is considerable effort being devoted to identify genetic mechanisms that control fat storage. Maria De Luca led a team from the University of Alabama at Birmingham, USA, who identified candidate genes using different strains of Drosophila.

On the basis of the results of these fly experiments, the research team then tested three common variations in the human LAMA5 gene and discovered two gene variants that were associated with body shape, one in women of European American descent and the other affecting women of American African descent. As De Luca reports, "We found one variant to be associated with weight and lean mass in both ethnic groups. This variant was also associated with height, total fat mass and HDL-cholesterol, but only in European American women. A different variant was associated with triglyceride levels and HDL-cholesterol in African American women."

The use of flies in a study of human obesity may seem strange, but according to De Luca "Insects store fat like mammals do, as lipid droplets accumulated in the fat body, the functional equivalent of both mammalian liver and white adipose tissue". She adds that, "Drosophila share many components of fat biosynthesis, degradation and regulation with humans, including many of those implicated in diabetes and obesity".


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-020-707-94804
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. Obesity and lack of exercise could enhance the risk of pancreatic cancer
3. Obesity and the central nervous system -- the state of the art
4. Obesity-related hormone is higher in children with Down syndrome
5. Australian researchers develop treatment to treat obesity
6. Study suggests link between obesity, poor bone health
7. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
8. Overeating and obesity triggered by lack of BDNF
9. Human hormone blocker found to help prevent obesity and diabetes: study
10. Moms obesity during conception phase may set the stage for offsprings obesity risk
11. What are the causes and consequences of childhood obesity?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... MILAN , March 24, 2017 The Controller ... Deputy Controller Mr. Abdulla Algeen have received the prestigious international ... Continue Reading ... ... small picture) and Deputy Controller Abdulla Algeen (small picture on the right) ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... 2017   Neurotechnology , a provider of ... announced the release of the SentiVeillance 6.0 ... facial recognition using up to 10 surveillance, security ... The new version uses deep neural-network-based facial detection ... utilizes a Graphing Processing Unit (GPU) for enhanced ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... (PRWEB) , ... April 18, 2017 , ... A number ... advances. This webinar, which is part of the Protein and Cell Analysis Education ... and outline where this technology fits in current and future applications. , Many ...
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics today announced that ... after the company changed focus to making analytical tools for biopharmaceutical quality control. ... technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart and David Erickson ...
(Date:4/19/2017)... ... April 19, 2017 , ... ... financing round. This event adds to several other early achievements at ThermaGenix, including ... Scientific Teams. , ThermaGenix will use proceeds from the Series A-1 ...
(Date:4/19/2017)... ... April 19, 2017 , ... As part of ... accessible to novices as well as experienced users, attendees will gain a better ... screening tests. , Hemostasis testing quality is determined by preanalytical variables which ...
Breaking Biology Technology: