Navigation Links
Obesity gene, carried by more than a third of the US population, leads to brain tissue loss
Date:4/19/2010

Three years ago, geneticists reported the startling discovery that nearly half of all people in the U.S. with European ancestry carry a variant of the fat mass and obesity associated (FTO) gene, which causes them to gain weight from three to seven pounds, on average but worse, puts them at risk for obesity.

Now, UCLA researchers have found that the same gene allele, which is also carried by roughly one-quarter of U.S. Hispanics, 15 percent of African Americans and 15 percent of Asian Americans, may have another deleterious effect.

Reporting in the early online edition of the journal Proceedings of the National Academy of Sciences, senior study author Paul Thompson, a UCLA professor of neurology; lead authors April Ho and Jason Stein, graduate students in Thompson's lab; and colleagues found that the FTO variant is also associated with a loss of brain tissue. This puts more than a third of the U.S. population at risk for a variety of diseases, such as Alzheimer's.

Using magnetic resonance imaging, the researchers generated three-dimensional "maps" of brain volume differences in 206 healthy elderly subjects drawn from 58 sites in the U.S. as part of the Alzheimer's Disease Neuroimaging Initiative, a large, five-year study aimed at better understanding factors that help the brain resist disease as it ages.

They found that there was consistently less tissue in the brains of those who carry the FTO allele, compared with non-carriers. Individuals with the "bad" version of the FTO gene had an average of 8 percent less tissue in the frontal lobes, the "command center" of the brain, and 12 percent less in the occipital lobes, areas in the back of the brain responsible for vision and perception. Further, the brain differences could not be directly attributed to other obesity-related factors such as cholesterol levels, diabetes or high blood pressure.

Thompson called the findings worrying and mysterious.

"The results are curious. If you have the bad FTO gene, your weight affects your brain adversely in terms of tissue loss," he said. "If you don't carry FTO, higher body weight doesn't translate into brain deficits; in fact, it has nothing to do with it. This is a very mysterious, widespread gene."

People who carry this specific DNA sequence are heavier on average, and their waist circumference is half an inch bigger.

This is a large percentage of the population, said Thompson, who is also a member of UCLA's Brain Research Institute and the UCLA Laboratory of Neuro Imaging.

"This is a shocking finding. Any loss of brain tissue puts you at greater risk for functional decline," he said. "The risk gene divides the world into two camps ― those who have the FTO allele and those who don't."

But the news is not necessarily completely negative, Thompson said, because "carriers of the risk gene can exercise and eat healthily to resist both obesity and brain decline."

Thompson sees both a public health message and a science message in this finding.

"Half of the world carries this dangerous gene. But a healthy lifestyle will counteract the risk of brain loss, whether you carry the gene or not. So it's vital to boost your brain health by being physically active and eating a balanced diet," he said.

And from a scientific standpoint, he said, "the gene discovery will help to develop and fine tune the anti-dementia drugs being developed to combat brain aging."


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Related biology news :

1. EVMS researchers identify potential target for treatment of obesity-related diseases
2. Eating disorders, obesity and communications experts tackle weighty matters
3. Rochester study connects workplace turmoil, stress and obesity
4. Einstein-Montefiore research tackles childhood obesity in the Bronx
5. Seaweed to tackle rising tide of obesity
6. STOP Obesity Alliance surveys show doctors, patients share role in weight loss, but ask, now what?
7. Obesity and passive smoking reduce oxygen supply to unborn baby
8. Babys obesity risk: Whats the mothers influence?
9. Center aims to cut obesity in black, Latino New Yorkers
10. Study finds that low-income women living in small cities have higher chance of obesity
11. Community involvement important in fight against childhood obesity, according to UTHealth researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
Breaking Biology Technology: