Navigation Links
Obesity and the central nervous system -- the state of the art

The past decade has witnessed an explosion of information regarding the role of the central nervous system (CNS) in the development of obesity and the influence of peripheral, hormonal signals that regulate CNS function to regulate food intake and metabolism. A symposium held recently in Washington, DC, organized by The Journal of Physiology, focused on recent work in talks by leaders in the field.

The speakers discussed state-of-the-art data and models regarding the brain as an initiator of obesity and as a target organ of peripheral feedback signals that regulate feeding behaviour. Reports of the talks by Barry Levin, Mary Dallman, and Gregory Morton are published in the September 1 issue of The Journal of Physiology, and they provide intriguing insights into the physiological basis of obesity.

As examples, Dr. Levin suggested that the physiological processes which drive all of us to seek and ingest food and limit energy expenditure during periods of negative energy balance provide an irresistible drive to regain lost adipose stores in weight-reduced obese individuals. This provides a potential basis for the well-recognized difficulty of maintaining weight loss. Dr. Dallman reported that conditions of reduced food allowance and chronic stress excite central neural networks that may lead toward abdominal obesity. This provides a potential link between stress and obesity.

Finally, Dr. Morton discussed that during a reduction in energy stores or circulating nutrients, the brain initiates responses to restore and maintain energy and glucose homeostasis. In contrast, in times of nutrient abundance and excess energy storage, the brain promotes reduced food intake and increased energy expenditure. An impaired ability of the brain to respond to hormonal or nutrient-related signals would be predicted to favour weight gain and insulin resistance and may contribute to the development of obesity and type 2 diabetes.

Together, these exciting presentations suggested potentially useful avenues of future research, which will hopefully provide improved preventive and therapeutic insights.

Contact: Melanie Thomson
Blackwell Publishing Ltd.

Related biology news :

1. Canadian youth 4th highest in international obesity study
2. Major link in brain-obesity puzzle found
3. Weight control protein may yield antiobesity drugs
4. Contagious obesity? Identifying the human adenoviruses that may make us fat
5. Study by Einstein researchers could lead to a novel strategy for treating obesity
6. Major obesity gene is lost in the shuffle
7. Sleep deprivation doubles risks of obesity in both children and adults
8. Higher levels of obesity associated with greater health risks
9. Obesity levels in US are grossly underestimated
10. Dragonflys metabolic disease provides clues about human obesity
11. Magic Beans -- Anti-obesity soya could help prevent diabetes
Post Your Comments:
(Date:11/12/2015)... , Nov. 11, 2015   Growing need ... analytical tools has been paving the way for ... determination of discrete analytes in clinical, agricultural, environmental, ... being predominantly used in medical applications, however, their ... sectors due to continuous emphasis on improving product ...
(Date:11/9/2015)... 09, 2015 ... the "Global Law Enforcement Biometrics Market ... --> ) has announced the ... Biometrics Market 2015-2019" report to their ... ( ) has announced the addition ...
(Date:10/29/2015)... MINNETONKA, Minn. , Oct. 29, 2015   ... that supports the entire spectrum of clinical research, is ... the Minnesota High Tech Association (MHTA) as one of ... in the "Software – Small and Growing" category. The ... and individuals who have shown superior technology innovation and ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... November 30, 2015 TapImmune, Inc. ... development of innovative peptide and gene-based immunotherapeutics and vaccines ... announced it will be presenting at the 8 th ... 2015 at 2.30 PM PT. Dr. John N. ... will be giving the presentation and will join TapImmune ...
(Date:11/30/2015)... BETHESDA, Md. , Nov. 30, 2015  Northwest ... biotechnology company developing DCVax® personalized immune therapies for solid ... to adding an additional independent director, and the Company ... investigation of allegations in a recent anonymous internet report ... on both initiatives. Linda Powers stated, ...
(Date:11/27/2015)... PA (PRWEB) , ... November 27, 2015 , ... ... Technical Program that includes over 2,000 technical presentations offered in symposia, oral ... chemistry and applied spectroscopy, covers a wide range of applications such as, but ...
(Date:11/25/2015)... , Nov. 25, 2015  PharmAthene, Inc. (NYSE ... has adopted a stockholder rights plan (Rights Plan) in ... operating loss carryforwards (NOLs) under Section 382 of the ... --> PharmAthene,s use of its NOLs could ... change" as defined in Section 382 of the Code. ...
Breaking Biology Technology: