Navigation Links
Obese stomachs tell us diets are doomed to fail
Date:9/16/2013

The way the stomach detects and tells our brains how full we are becomes damaged in obese people but does not return to normal once they lose weight, according to new research from the University of Adelaide.

Researchers believe this could be a key reason why most people who lose weight on a diet eventually put that weight back on.

In laboratory studies, University of Adelaide PhD student Stephen Kentish investigated the impact of a high-fat diet on the gut's ability to signal fullness, and whether those changes revert back to normal by losing weight.

The results, published in the International Journal of Obesity, show that the nerves in the stomach that signal fullness to the brain appear to be desensitized after long-term consumption of a high-fat diet.

"The stomach's nerve response does not return to normal upon return to a normal diet. This means you would need to eat more food before you felt the same degree of fullness as a healthy individual," says study leader Associate Professor Amanda Page from the University's Nerve-Gut Research Laboratory.

"A hormone in the body, leptin, known to regulate food intake, can also change the sensitivity of the nerves in the stomach that signal fullness. In normal conditions, leptin acts to stop food intake. However, in the stomach in high-fat diet induced obesity, leptin further desensitizes the nerves that detect fullness.

"These two mechanisms combined mean that obese people need to eat more to feel full, which in turn continues their cycle of obesity."

Associate Professor Page says the results have "very strong implications for obese people, those trying to lose weight, and those who are trying to maintain their weight loss".

"Unfortunately, our results show that the nerves in the stomach remain desensitized to fullness after weight loss has been achieved," she says.

Associate Professor Page says they're not yet sure whether this effect is permanent or just long-lasting.

"We know that only about 5% of people on diets are able to maintain their weight loss, and that most people who've been on a diet put all of that weight back on within two years," she says.

"More research is needed to determine how long the effect lasts, and whether there is any way chemical or otherwise to trick the stomach into resetting itself to normal."


'/>"/>

Contact: Amanda Page
amanda.page@adelaide.edu.au
61-882-225-644
University of Adelaide
Source:Eurekalert

Related biology news :

1. Obese dads pass on predisposition to obesity and metabolic disorders to their kids
2. Food contaminants worsen metabolic problems in obese mice
3. People with a disability more likely to be obese, have chronic illnesses
4. Obese male mice father offspring with higher levels of body fat
5. Eating fewer, larger meals may prove healthier for obese women
6. Obese dogs at risk of health condition experienced by humans
7. Obese moms give birth to heart healthier kids following bariatric surgery
8. Obese patients face higher radiation exposure from CT scans -- but new technology can help
9. Researchers unravel genetic mechanism of fatty liver disease in obese children
10. New study compares diets for weight management in obese children
11. Diets low in polyunsaturated fatty acids may be a problem for youngsters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... to grow at a CAGR of 30.37% during the period 2017-2021. ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... A best-selling author and ... companies. “Grit” author Angela Duckworth and her team at Character Lab have joined ... an international law firm with decades of experience supporting high-growth companies in the ...
(Date:9/19/2017)... Calif. and Washington, D.C. (PRWEB) , ... September ... ... delivering rapid care during an biological outbreak is about to be eliminated, said ... asked what makes ExcitePCR’s FireflyDX™ technologies different than other pathogen detection ...
(Date:9/19/2017)... ... September 19, 2017 , ... Molecular Devices, LLC, a leader ... to launch the CloneSelect™ Single-Cell Printer™ in North America. This novel system ... provide visual documentation of monoclonality for use in cell line development. , ...
(Date:9/18/2017)... ... September 18, 2017 , ... ... to produce biochar, briquettes, and torrefied wood is the topic of a ... To characterize the potential economic viability of transportable biomass conversion facilities for producing ...
Breaking Biology Technology: