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Obese moms give birth to heart healthier kids following bariatric surgery
Date:10/28/2012

at maternal bariatric surgery results in significant metabolic effects to the methylation profiles of inflammatory disease-related genes," says Dr. Gunard. "The bariatric surgery and weight loss experienced by the mothers created an in utero environment that favorably changed the gene methylation levels of the fetus."

"Basically, this study tells us that maternal obesity affects the obesity and cardiovascular risk profile of offspring and that weight loss can improve the cardiovascular health of children."

"We know our genetic makeup influences our children's risks but so can our environment," says Heart and Stroke Foundation spokesperson Dr. Beth Abramson. "For example, if a disease runs in a family, we know to watch out for it in the children as they age. This study shows that external factors also influence our risk for heart disease and that of our offspring by switching genes on or off in our DNA; providing a glimpse as to why this occurs. This is why lifestyle behaviours are so important."

Dr. Abramson says this study is another reminder about why we need to manage and control our weight at all stages of life. "What other things could we be doing to flip those switches and provide a better blueprint for our kids to start them off right in life?"

Dr. Gunard says we would need other genetics studies to find out if weight loss changes the methylation profile of the genes of offspring of women who have lost weight through other measures.


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Contact: Jane-Diane Fraser
jfraser@hsf.ca
613-569-4361 x273
Heart and Stroke Foundation of Canada
Source:Eurekalert

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