Navigation Links
Obese male mice father offspring with higher levels of body fat
Date:6/16/2013

SAN FRANCISCO (June 16, 2013)Male mice who were fed a high-fat diet and became obese were more likely to father offspring who also had higher levels of body fat, a new Ohio University study finds.

The effect was observed primarily in male offspring, despite their consumption of a low-fat diet, scientists reported today at the annual meeting of The Endocrine Society in San Francisco, Calif.

"We've identified a number of traits that may affect metabolism and behavior of offspring dependent on the pre-conception diet of the father," said Felicia Nowak, an associate professor of biomedical sciences in Ohio University's Heritage College of Osteopathic Medicine who is lead author on the study.

The researchers point to epigeneticsthe way genes are expressed, as opposed to mutations in DNA that are "hard-wired into the genes"as a possible cause of these inherited traits. Because gene expression is impacted by environmental and lifestyle factors, this finding suggests that individuals with obese fathers may be able to proactively address health concerns.

The effect of parents' diet and weight on children has been well-established in humans, Nowak explained, but scientists have been studying the issue in mice to learn more about the biological mechanisms behind the phenomenon. The Ohio University team studied the impact of the high-fat diet only with male mice parents, as most of the previous research had focused on female mice parents.

To conduct the study, the researchers fed male mice a high-fat diet for 13 weeks before mating. (The female mates were fed a matched low-fat diet.) Male and female offspring were fed a standard low-fat diet and studied at 20 days, six weeks and at six and 12 months.

Compared with offspring from control mice (who were fed the low-fat diet), the male offspring of paternal mice with diet-induced obesity had higher body weight at six weeks of age. They also were more obese at the six- and 12-month study markers. In addition, the male offspring of obese fathers had different patterns of body fat compositiona marker for health and propensity for diseasethan the control mice.

The researchers were surprised, however, to find that the offspring of the obese paternal mice also were more physically active. At six weeks, the male offspring voluntarily ran more, and their female siblings demonstrated the same behavior at six and 12 months, the scientists report. Nowak's team is studying possible causes for this behavior, which might offset the increased body fat and reduce the offspring's risk of metabolic disease such as diabetes and heart disease.

In the next phase of the research, the team will seek to identify the genes responsible for the physiological and behavioral changes. This, in turn, may inform clinicians about possible epigenetic factors in human obesity.

"Early detection and prediction of risk for obesity, diabetes and related diseases will enable individuals and health care workers to delay or prevent the related disabilities and increase life expectancy," Nowak said. The study was funded by the Ohio University Research Council and the Heritage College of Osteopathic Medicine.


'/>"/>

Contact: Andrea Gibson
gibsona@ohio.edu
740-597-2166
Ohio University
Source:Eurekalert

Related biology news :

1. New study compares diets for weight management in obese children
2. Researchers unravel genetic mechanism of fatty liver disease in obese children
3. Obese patients face higher radiation exposure from CT scans -- but new technology can help
4. Obese moms give birth to heart healthier kids following bariatric surgery
5. Obese dogs at risk of health condition experienced by humans
6. Eating fewer, larger meals may prove healthier for obese women
7. First paternity study of southern right whales finds local fathers most successful
8. Happy Fathers Day! Another reason why dads and hopeful dads should quit smoking now
9. The old primates club: Even male monkeys ride their fathers coattails to success
10. Penn Study shows resistance to cocaine addiction may be passed down from father to son
11. Common genetic disease linked to fathers age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the ... by The Prince,s Trust to uncover insights to support ... The Trust. The UK,s leading youth charity will be ... campaign results and get a better understanding of the topics and ... ...
(Date:3/2/2017)... YORK , March 2, 2017 Summary ... better understand Perrigo and its partnering interests and activities since ... ... Partnering Deals and Alliance since 2010 report provides an in-depth ... leading life sciences companies. On demand company reports ...
(Date:3/2/2017)... , March 2, 2017 Australian stem cell ... (ASX: CYP), has signed an agreement with the Monash ... Monash Biomedicine Discovery Institute and Department of Pharmacology at ... a further preclinical study to support the use of ... asthma.  Asthma is a chronic, long ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... , ... March 23, 2017 , ... ... material that exhibits both viscous and elastic characteristics when deformed, which is identical ... exhibits properties to gently absorb compressive forces and return to its natural state ...
(Date:3/23/2017)... , March 23, 2017  SeraCare ... to global in vitro diagnostics manufacturers and ... the industry,s first multiplexed Inherited Cancer ... testing by next-generation sequencing (NGS). The Seraseqâ„¢ ... developed with input from industry experts to ...
(Date:3/23/2017)... , March 23, 2017 Kineta, ... development of novel therapies in immuno-oncology, today announced ... lead" small molecule compounds that activate interferon response ... pathways and demonstrate immune-mediated tumor regression in a ... the study who demonstrated complete tumor regression to ...
(Date:3/23/2017)... 2017 In today,s pre-market research, ... the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate ... SYN), and Regulus Therapeutics Inc. (NASDAQ: RGLS ... Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn ... at: ...
Breaking Biology Technology: