Navigation Links
Obese dieters' brain chemistry works against their weight-loss efforts
Date:6/23/2011

URBANA If you've been trying to lose weight and suspect your body's working against you, you may be right, according to a University of Illinois study published in Obesity.

"When obese persons reduce their food intake too drastically, their bodies appear to resist their weight loss efforts. They may have to work harder and go slower in order to outsmart their brain chemistry," said Gregory G. Freund, a professor in the U of I College of Medicine and a member of U of I's Division of Nutritional Sciences.

He particularly cautions against beginning a diet with a fast or cleansing day, which appears to trigger significant alterations in the immune system that work against weight loss. "Take smaller steps to start your weight loss and keep it going," he said.

In the study, the scientist compared the effects of a short-term fast on two groups of mice. For 12 weeks, one group consumed a low-fat diet (10 percent fat); the other group was fed a high-fat (60 percent fat) and had become obese. The mice were then fasted for 24 hours. In that time, the leaner mice lost 18 percent of their body weight compared to 5 percent for the obese mice.

Freund said that there is an immune component to weight loss that has not been recognized. "Our data show that fasting induces an anti-inflammatory effect on a lean animal's neuroimmune system, and that effect is inhibited by a high-fat diet. Some of the brain-based chemical changes that occur in a lean animal simply don't occur in an obese animal," he said.

This breakdown occurs because obese animals resist downregulation of genes that activate the interleukin-1 (IL-1) system and associated anti-inflammatory cytokines, he said.

The scientist also studied differences in the behavior of the two groups of mice, monitoring how much they moved, administering tests to discern the animals' ability to learn and remember, and noting whether the mice exhibited signs of depression
'/>"/>

Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nearly 1 in 4 postmenopausal women with fractures is obese
2. Religious young adults become obese by middle age
3. Stigma weighs heavily on obese people, contributing to greater health problems
4. New sleep cycle discovery explains why fatty diets during pregnancy make kids obese
5. Clinical study supports benefit of breastfeeding support for obese women
6. Moderate weight loss in obese people improves heart function
7. It can be predicted the reaction obese patients will have to a diet
8. Improved diet and exercise alone unlikely to cure obstructive sleep apnea in obese patients
9. Owners should count calories for obese pets, consider several factors for good health
10. Study explains potential failure of oral contraceptives with obese women
11. Study suggests obese women should not gain weight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/23/2015)... Conn. , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces its ... new advertising campaign on CNBC television starting March 30 th ... will commence airing in New York ... Officer said: "We are excited about our new ad campaign ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... 2009) -- A husband and wife team of American paleontologists has ... ago during the early Cretaceous of central Montana. The new ... of the Canadian Journal of Earth Sciences . Ankylosaurs are ... a plate-like armour with two sets of sharp spikes on each ...
... decades, climate scientists have worked to identify and measure key ... affect Earth,s climate. And they,ve been aided by ever more ... each type of pollutant more reliable. Yet the ... it -- continues to serve up surprises. The most recent? ...
... KATHMANDU, October 30 - China received praise here today from ... its neighbors to end tiger trade and bring back wild ... opposed to tiger trade from any source, praised comments by ... the Kathmandu Global Tiger Workshop, who pledged to replace the ...
Cached Biology News:New dinosaur species from Montana 2Interactions with aerosols boost warming potential of some gases 2Interactions with aerosols boost warming potential of some gases 3Interactions with aerosols boost warming potential of some gases 4Asia's biggest 'tiger' unviels promise for wild tigers 2
(Date:4/16/2015)... 2015 Avelas Biosciences, an in vivo ... announced today that it has initiated a Phase 1b ... women with primary, non-recurrent breast cancer undergoing surgery. In ... addition of Steven Chen , M.D., as vice ... dose escalation study will enroll up to 39 women ...
(Date:4/16/2015)... Switzerland , April 16, 2015 /PRNewswire/ ... Debiopharm Group ™ , a Swiss-based global biopharmaceutical ... medical needs as well as companion diagnostics, ... investigational compounds Debio 1143 (SMAC mimetic) and Debio 1347/CH5183284 ... the 2015 Annual meeting of the American Association for Cancer Research ...
(Date:4/16/2015)... April 16, 2015 Fairleigh Dickinson ... V. Gulfo to become the Executive Director of ... FDU announced the kick-off of the Initiative for ... by Dr. Gulfo, under the Rothman Institute of ... Business) and in collaboration with FDU’s School of ...
(Date:4/16/2015)... 2015 Dana-Farber Cancer Institute and ... Resolution Bioscience, Inc. today announced the successful completion ... blood-based, clinic ready, Next Generation Sequencing (NGS) assay ... is the first to demonstrate the successful sequencing ... in blinded plasma samples and highlights the ability ...
Breaking Biology Technology:Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 3Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 2Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 3Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 2Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 3Resolution Bioscience announces successful collaboration on a novel, non-invasive, targeted NGS test for lung cancer 2Resolution Bioscience announces successful collaboration on a novel, non-invasive, targeted NGS test for lung cancer 3
... Immunotec,looks to the beginning of its twelfth year ... C.H. (Chuck) Roberts announces,his retirement from his role ... will continue his involvement with the corporation, both ... and as Co-founder, in a variety,of public relations ...
... 26 InterMune, Inc.,(Nasdaq: ITMN ) today ... shares of common stock at a price to ... of common stock, representing the exercise,by the underwriters ... the,offering. The net proceeds to the company of ...
... Sept. 26 Advanced Bio-Technologies,Inc (ABT) is pleased to ... purchased by HealthEdge Investment Partners of Tampa,FL. (http://www.healthedgepartners.com ... "This is a new stage,in the exciting development of ... marketing in the USA, build the necessary infrastructure for ...
Cached Biology Technology:Immunotec Inc. announces retirement of President & CEO C.H. (Chuck) Roberts 2InterMune Announces Closing of Public Offering of Common Stock 2Advanced Bio-Technologies Inc Announces Acquisition by HealthEdge Investment Partners, Tampa FL 2
Recommended for use as a cell culture substratum at 0.1-0.2 mg/cm 2 or 5-10 μl/cm 2 . Optimal concentration depends on cell type as well as the application or research objectives. Type B...
... Yellow crystalline solid. PROTECT FROM LIGHT. Useful in ... required. Purity: ≥98% by TLC. Soluble in ... preparation of a 10 mM stock in DMSO is ... to H 2 O with rapid mixing (e.g. 10 ...
... IgM binds poorly to Protein A and, ... existed for one- step IgM purification. Standard methods ... or they are not effective for removing all ... Pierce has developed ...
... 3′-(α-Amino- p- methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyladenosine, 2HCl ... FROM MOISTURE. Protein synthesis inhibitor. Inhibits ... nascent polypeptide chains. Induces DNA fragmentation ... leukemia cells. Purity: ≥98% by ...
Biology Products: