Navigation Links
OU researchers find way to prevent blindness in research model for retinitis pigmentosa
Date:6/11/2010

Researchers at the University of Oklahoma Health Sciences Center have found a way to use a radical new type of gene therapy to prevent blindness caused by retinitis pigmentosa, giving hope to the estimated 100,000 Americans who suffer from this debilitating disease.

The study appears in the Journal of the Federation of American Societies for Experimental Biology (FASEB).

The research, led by Muna Naash, Ph.D., at the University of Oklahoma Health Sciences Center, with collaborators in Cleveland and Buffalo, discovered a way to deliver known gene therapies directly to the light-sensitive cells affected by this disease.

The discovery already is being used to develop new treatments for another disease macular degeneration, the leading cause of blindness in the United States.

"I am thrilled about it. That's why we have been working so hard to get this as quickly as possible through the necessary experiments, so we can publish our findings and take it out to the patients," Naash said. "We hope the results of our study will be instrumental in generating a cure for the debilitating blindness associated with retinitis pigmentosa and other inherited and acquired retinal diseases. We want to give Oklahomans and others suffering from these diseases renewed independence and quality of life."

Utilizing nanoparticle technology, scientists created a microscopic capsule capable of carrying genetic therapies to their destination inside cells of the retina. The tiny delivery vehicle is being tested with a variety of gene therapies in animal models with the potential of treating several diseases from bladder cancer to diabetes. The capsules have proven very effective, carrying therapies to the designated location in the eye within 15 minutes of delivery and spreading the genetic repair message quickly to nearby cells.

"This is an incredible breakthrough in terms of being able to treat with gene therapy," said Robert E. Leonard, M.D., an ophthalmologist at the Dean McGee Eye Institute. "Outside of gene therapy, we are at a loss to be able to treat these patients, so this is incredibly important research. It's breathtaking, very exciting."


'/>"/>

Contact: Diane Clay
diane-clay@ouhsc.edu
405-271-2323
University of Oklahoma
Source:Eurekalert  

Related biology news :

1. Texas A&M veterinary researchers achieve cloning first
2. Researchers discover mechanism that limits scar formation
3. Researchers identify gene linked to hereditary incontinence
4. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
5. Lasers help researchers predict birds preferred habitat
6. Researchers find gene linked to birth defects
7. Yale researchers develop test to identify best sperm
8. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
9. UCI researchers create retina from human embryonic stem cells
10. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
11. Researchers discover new mechanism for clearing blockages from smallest blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
OU researchers find way to prevent blindness in research model for retinitis pigmentosa
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted to ... of 2015 The gross margin was 49% (27) ... operating margin was 40% (-13) Earnings per share rose ... was SEK 249.9 M (21.2) , Outlook   ... The operating margin for 2016 is estimated to exceed ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... York , May 4, 2016 ... Transparency Market Research "Metabolomics Market - Global Industry Analysis, ... the metabolomics market is anticipated to expand at a ... USD 2,494.8 million by 2024. Metabolomics is ... metabolites, within cells, biofluids, tissues or organisms. Together, these ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nutrafol®, a first-to-market smart-supplement for ... and stress related hair loss. With patent-pending formulas for both female hair loss ... in the medical and salon channels nationwide. , Dermatologists, Plastic Surgeons and ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... ... enterprise talent development, skill-building and compliance training platform on mobile devices, today ... course: Overview of Regulatory Requirements for Medical Devices. The course is essential for ...
(Date:5/3/2016)... Boston, Massachusetts (PRWEB) , ... May 03, 2016 ... ... communities will gather at Boston CEO 2016 on May 31st and June 1st ... off-the-record networking forum for leading executives in the life sciences, offering exclusive access ...
Breaking Biology Technology: