Navigation Links
OU researchers find way to prevent blindness in research model for retinitis pigmentosa
Date:6/11/2010

Researchers at the University of Oklahoma Health Sciences Center have found a way to use a radical new type of gene therapy to prevent blindness caused by retinitis pigmentosa, giving hope to the estimated 100,000 Americans who suffer from this debilitating disease.

The study appears in the Journal of the Federation of American Societies for Experimental Biology (FASEB).

The research, led by Muna Naash, Ph.D., at the University of Oklahoma Health Sciences Center, with collaborators in Cleveland and Buffalo, discovered a way to deliver known gene therapies directly to the light-sensitive cells affected by this disease.

The discovery already is being used to develop new treatments for another disease macular degeneration, the leading cause of blindness in the United States.

"I am thrilled about it. That's why we have been working so hard to get this as quickly as possible through the necessary experiments, so we can publish our findings and take it out to the patients," Naash said. "We hope the results of our study will be instrumental in generating a cure for the debilitating blindness associated with retinitis pigmentosa and other inherited and acquired retinal diseases. We want to give Oklahomans and others suffering from these diseases renewed independence and quality of life."

Utilizing nanoparticle technology, scientists created a microscopic capsule capable of carrying genetic therapies to their destination inside cells of the retina. The tiny delivery vehicle is being tested with a variety of gene therapies in animal models with the potential of treating several diseases from bladder cancer to diabetes. The capsules have proven very effective, carrying therapies to the designated location in the eye within 15 minutes of delivery and spreading the genetic repair message quickly to nearby cells.

"This is an incredible breakthrough in terms of being able to treat with gene therapy," said Robert E. Leonard, M.D., an ophthalmologist at the Dean McGee Eye Institute. "Outside of gene therapy, we are at a loss to be able to treat these patients, so this is incredibly important research. It's breathtaking, very exciting."


'/>"/>

Contact: Diane Clay
diane-clay@ouhsc.edu
405-271-2323
University of Oklahoma
Source:Eurekalert  

Related biology news :

1. Texas A&M veterinary researchers achieve cloning first
2. Researchers discover mechanism that limits scar formation
3. Researchers identify gene linked to hereditary incontinence
4. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
5. Lasers help researchers predict birds preferred habitat
6. Researchers find gene linked to birth defects
7. Yale researchers develop test to identify best sperm
8. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
9. UCI researchers create retina from human embryonic stem cells
10. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
11. Researchers discover new mechanism for clearing blockages from smallest blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
OU researchers find way to prevent blindness in research model for retinitis pigmentosa
(Date:2/2/2016)... 2016  BioMEMS devices deployed in hospitals ... medical screening and diagnostic applications, such as ... that facilitate and assure continuous monitoring without ... being bolstered through new opportunities offered by ... coupled with wireless connectivity and low power ...
(Date:2/2/2016)... 2016 Technology Enhancements Accelerate Growth of X-ray Imaging ... digital and computed radiography markets in Thailand ... Indonesia (TIM). It provides an in-depth ... well as regional market drivers and restraints. The study ... and market attractiveness, both for digital and computed radiography. ...
(Date:2/1/2016)... Canada , February 1, 2016 ... technological advancements to drive global touchfree intuitive gesture control ... --> Rising sales of consumer electronics coupled ... gesture control market size through ... consumer electronics coupled with new technological advancements to drive ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Florida , February 11, 2016 ... and Promote Genetic Understanding to Support Research and Discovery ... GenomeAsia 100K, today announced an ambitious plan to sequence 100,000 ... South Asian countries and at least 7 of North and ... In the first phase, the project will focus on ...
(Date:2/11/2016)... Feb. 11, 2016  Bioethics International, a not-for-profit organization focused ... developed, marketed and made accessible to patients around the world, ... had named the publication of the Good Pharma Scorecard ... is also featured as one of BMJ Open ,s ... year that are most frequently read. Ed Sucksmith ...
(Date:2/11/2016)... , Feb. 11, 2016  Dovetail Genomics™ LLC today ... beta program for a planned metagenomic genome assembly service. ... company,s metagenomic genome assembly method in a talk on ... Biology & Technology conference in Orlando, Fla. ... highly complex datasets is difficult. Using its proprietary ...
(Date:2/11/2016)... ... 2016 , ... Global Stem Cells Group, a ... Stem Cells Network (GSCN) to distribute exosome injection and other biological products to ... Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, El Salvador, Venezuela, Peru, Ecuador, Paraguay, ...
Breaking Biology Technology: