Navigation Links
OU research team achieves $4.5 million Defense grant
Date:5/23/2014

A University of Oklahoma research team has been awarded a five-year, $4.5 million grant from the Defense Threat Reduction Agency to address the growing problem of three specific antibiotic resistant pathogens causing devastating infections in hospitals and in persons with cystic fibrosis. The OU research team achieved the only grant of its kind to perform research that potentially will lead to the design of effective antibiotic drugs.

Helen Zgurskaya, principal investigator and professor of chemistry and biochemistry in the OU College of Arts and Sciences, will direct the investigation of these three pathogens known to resist most clinically relevant antibiotics. Co-investigators on the project include Valentin Rybenkov, professor of chemistry and biochemistry in the OU College of Arts and Sciences; and James Aggen, professor of medicinal chemistry at Northeastern University.

"Our team will focus on the structural components that make the pathogenic cells resistant to antibiotics. In the process, we also will look at physico-chemical properties that allow antibiotics to penetrate the cell membrane and determine how to make these antibiotics effective against resistant bacteria. A comparison of antibiotics with different physico-chemical properties will help us understand the mechanisms and develop a realistic predictive model that will facilitate development of antibiotics capable of penetrating the cell wall of these bacteria," says Zgurskaya.

Initially, the team will develop protocols for comparing different properties of compounds. Currently, there is no single technique to measure how various antibiotics get into the cell. Aggen will assemble a library of compounds with different properties for measurement. Rybenkov will select the best method for analyzing how compounds penetrate the cells. The team plans to use fluorescence, mass-spectroscopy and a single cell molecule methodology.

As an end goal, the team will establish a "set of rules" for how antibiotics get into the cell. This approach will not only aid in the development of new and more effective antibiotics but will suggest new approaches in the fight against human pathogens. If interested in learning more about this research, please contact Helen Zgurskaya at elenaz@ou.edu.


'/>"/>

Contact: Jana Smith
jana.smith@ou.edu
405-325-1322
University of Oklahoma
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation ... Physics and Astronomy, has been selected for membership in ARCS Alumni Hall of ... Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of the ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography ... generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase ...
(Date:10/7/2017)... ... October 06, 2017 , ... Phase ... metagenome deconvolution product, featuring the first commercially available Hi-C kit. Researchers can ... Hi-C metagenome deconvolution using their own facilities, supplementing the company’s full-service ProxiMeta ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... healthcare and technology sector at their fourth annual Conference where founders, investors, innovative ... speakers and the ELEVATE pitch competition showcasing early stage digital health and med ...
Breaking Biology Technology: