Navigation Links
OU research team achieves $4.5 million Defense grant
Date:5/23/2014

A University of Oklahoma research team has been awarded a five-year, $4.5 million grant from the Defense Threat Reduction Agency to address the growing problem of three specific antibiotic resistant pathogens causing devastating infections in hospitals and in persons with cystic fibrosis. The OU research team achieved the only grant of its kind to perform research that potentially will lead to the design of effective antibiotic drugs.

Helen Zgurskaya, principal investigator and professor of chemistry and biochemistry in the OU College of Arts and Sciences, will direct the investigation of these three pathogens known to resist most clinically relevant antibiotics. Co-investigators on the project include Valentin Rybenkov, professor of chemistry and biochemistry in the OU College of Arts and Sciences; and James Aggen, professor of medicinal chemistry at Northeastern University.

"Our team will focus on the structural components that make the pathogenic cells resistant to antibiotics. In the process, we also will look at physico-chemical properties that allow antibiotics to penetrate the cell membrane and determine how to make these antibiotics effective against resistant bacteria. A comparison of antibiotics with different physico-chemical properties will help us understand the mechanisms and develop a realistic predictive model that will facilitate development of antibiotics capable of penetrating the cell wall of these bacteria," says Zgurskaya.

Initially, the team will develop protocols for comparing different properties of compounds. Currently, there is no single technique to measure how various antibiotics get into the cell. Aggen will assemble a library of compounds with different properties for measurement. Rybenkov will select the best method for analyzing how compounds penetrate the cells. The team plans to use fluorescence, mass-spectroscopy and a single cell molecule methodology.

As an end goal, the team will establish a "set of rules" for how antibiotics get into the cell. This approach will not only aid in the development of new and more effective antibiotics but will suggest new approaches in the fight against human pathogens. If interested in learning more about this research, please contact Helen Zgurskaya at elenaz@ou.edu.


'/>"/>

Contact: Jana Smith
jana.smith@ou.edu
405-325-1322
University of Oklahoma
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/16/2017)... Feb. 16, 2017  Genos, a community for ... it has received Laboratory Accreditation from the College ... presented to laboratories that meet stringent requirements around ... rigorous processes. "Genos is committed to ... practices. We,re honored to be receiving CAP accreditation," ...
(Date:2/10/2017)... Research and Markets has announced the addition of ... Commercial Aspects" to their offering. ... Biomarkers play an important ... selection of treatment as well for monitoring the results. There ... modern medicine. Biochip/microarray technologies and next generation sequencing are also ...
(Date:2/8/2017)... NEW YORK , Feb. 7, 2017 Report ... ... and should reach $11.4 billion by 2021, growing at a ... Report Includes - An overview of the global markets for ... from 2015, estimates for 2016, and projections of compound annual ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... SAN JOSE, Calif. , Feb. 23, 2017 ... an exclusive license for two key immunotherapy technologies ... The first technology provides a method to monitor ... therapy such as PD-L1 and CTLA-4.  The second ... detect if a patient is likely to have ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... evaluation of multiple immunoassay-based threat detection technologies by researchers from the Pacific ... biosensor threat detection technology was found to have the best level of ...
(Date:2/23/2017)... Feb. 23, 2017 Aviva Systems Biology ... the acquisition of GenWay Biotech Incorporated, a protein ... and product offering for both the research and ... growth and enhance capabilities for both entities. GenWay,s 18 ... assays will nicely complement ASB,s objective to become ...
(Date:2/22/2017)... ... 2017 , ... Park Systems , a leader in Atomic Force Microscopy ... SPIE attendees and Park customers on Feb. 27, 2017 from 12-2pm at Morton’s ... Center. The luncheon will feature a talk on Automated AFM for Small-Scale and ...
Breaking Biology Technology: