Navigation Links
ORNL invention unravels mystery of protein folding
Date:9/14/2011

OAK RIDGE, Tenn., Sept. 14, 2011 -- An Oak Ridge National Laboratory invention able to quickly predict three-dimensional structure of protein could have huge implications for drug discovery and human health.

While scientists have long studied protein structure and the mechanism of folding, this marks the first time they are able to computationally predict three-dimensional structure independent of size of the protein. Because the invention also determines possible intermediate states in the protein folding process, it provides a clearer picture and could open doors to designing new medicines for neurodegenerative diseases that are caused by incorrectly folded proteins.

Pratul Agarwal, inventor of the method and a member of the Department of Energy lab's Computer Science and Mathematics Division, believes this new method will provide benefits in many areas.

"This finding is relevant to energy, climate and health, which are all of tremendous significance today," Agarwal said. "We expect this approach to have many industrial applications through protein engineering, for example, where we expect to be able to design more efficient enzymes."

Proteins often adopt a three-dimensional structure that allows them to carry out their designated function, but such a structure has provided a computationally challenging task. Using the fundamental insights of the protein structure, dynamics and function, the ORNL invention discloses a unique computational methodology to explore the conformational energy landscape of a protein.

"One of the main advantages of this approach is that it follows the natural intrinsic dynamics of the protein and by promoting the relevant dynamical modes allows rapid exploration of the folding pathway and prediction of the protein structure," Agarwal said.

In the area of drug development, Agarwal, a computational biophysicist, expects this discovery to help in the development of treatments with little or no side effects.


'/>"/>
Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

Related biology news :

1. Rice bioengineering students invention may help diagnose painful eye condition
2. Oxygen sensor invention could benefit fisheries to breweries
3. Inventions of evolution: What gives frogs a face
4. Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy
5. Invention helps students learn surgical techniques before operating on patients
6. New invention could improve treatment for children with water on the brain
7. Tel Aviv University invention busts dust
8. UGA licenses invention that kills food-borne pathogens in minutes
9. Study unravels why certain fishes went extinct 65 million years ago
10. Yale researchers solve mystery of disappearing bird digit
11. The unsolved mystery of kava toxicity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... N.C. (PRWEB) , ... June 27, 2016 , ... ... commercial operations for Amgen, will join the faculty of the University of ... as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
Breaking Biology Technology: