Navigation Links
ORNL invention unravels mystery of protein folding
Date:9/14/2011

OAK RIDGE, Tenn., Sept. 14, 2011 -- An Oak Ridge National Laboratory invention able to quickly predict three-dimensional structure of protein could have huge implications for drug discovery and human health.

While scientists have long studied protein structure and the mechanism of folding, this marks the first time they are able to computationally predict three-dimensional structure independent of size of the protein. Because the invention also determines possible intermediate states in the protein folding process, it provides a clearer picture and could open doors to designing new medicines for neurodegenerative diseases that are caused by incorrectly folded proteins.

Pratul Agarwal, inventor of the method and a member of the Department of Energy lab's Computer Science and Mathematics Division, believes this new method will provide benefits in many areas.

"This finding is relevant to energy, climate and health, which are all of tremendous significance today," Agarwal said. "We expect this approach to have many industrial applications through protein engineering, for example, where we expect to be able to design more efficient enzymes."

Proteins often adopt a three-dimensional structure that allows them to carry out their designated function, but such a structure has provided a computationally challenging task. Using the fundamental insights of the protein structure, dynamics and function, the ORNL invention discloses a unique computational methodology to explore the conformational energy landscape of a protein.

"One of the main advantages of this approach is that it follows the natural intrinsic dynamics of the protein and by promoting the relevant dynamical modes allows rapid exploration of the folding pathway and prediction of the protein structure," Agarwal said.

In the area of drug development, Agarwal, a computational biophysicist, expects this discovery to help in the development of treatments with li
'/>"/>

Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rice bioengineering students invention may help diagnose painful eye condition
2. Oxygen sensor invention could benefit fisheries to breweries
3. Inventions of evolution: What gives frogs a face
4. Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy
5. Invention helps students learn surgical techniques before operating on patients
6. New invention could improve treatment for children with water on the brain
7. Tel Aviv University invention busts dust
8. UGA licenses invention that kills food-borne pathogens in minutes
9. Study unravels why certain fishes went extinct 65 million years ago
10. Yale researchers solve mystery of disappearing bird digit
11. The unsolved mystery of kava toxicity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... Three years after the Hesperides vessel returned to Spain ... researchers have an increasingly clear picture of how the ... Specifically, the input of pollutants from the atmosphere is ... the most remote areas of the planet, and it ... findings are presented this week in CSIC Residence for ...
(Date:9/16/2014)... a peacock show its extravagant, colorful tail feathers in ... have used a special camera developed by an engineer ... female northern swordtail fish choose their mates based on ... of Texas at Austin used a bioinspired polarization camera ... science & engineering at Washington University, to make the ...
(Date:9/16/2014)... the salmon-rich waters of Southeast Alaska to the white ... lobster, lumber and tourist towns, coastal residents around the ... environments divide along political lines. That,s a primary finding ... sociologists published this month in the journal Society ... of environment-related differences from place to place to place. ...
Breaking Biology News(10 mins):The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3Camera developed at WUSTL sheds light on mate choice of swordtail fish 2Politics divide coastal residents' views of environment, UNH research finds 2Politics divide coastal residents' views of environment, UNH research finds 3
... MADISON A discovery at the University of Wisconsin-Madison ... create a "hydrogen economy" that would use this abundant ... hydrogen is the ultimate non-carbon, non-polluting fuel for storing ... for energy, hydrogen produces water but no carbon dioxide. ...
... the bacteria that form the base of the ocean,s ... a new study. In climate change, as in ... dioxide levels and temperature rise globally, scientists increasingly want ... perish in the environment of tomorrow. The answer ...
... Brookhaven National Laboratory have identified two promising candidates for ... of ailments ranging from colds to gastrointestinal disorders to ... , a journal of the Federation of European Biochemical ... compounds to determine which might block the effects of ...
Cached Biology News:New catalyst could cut cost of making hydrogen fuel 2Greenhouse gas likely altering ocean foodchain 2Scientists identify promising antiviral compounds 2Scientists identify promising antiviral compounds 3
(Date:9/16/2014)... , Sept. 16, 2014  Donald Fresne, President and CEO ... Stephan Vagner , PhD to its Scientific Advisory Committee. ... Toulouse, France , performed research at Embl ... and at Inserm, the French institute of health and medical ... both at the Curie Institute, Orsay, France ...
(Date:9/16/2014)... TN (PRWEB) September 16, 2014 ... new initiatives to position themselves for their ... for labeling and encoding, Pharma Packaging Solutions ... new hardware and software and new procedures. ... current Good Manufacturing Practices (cGMP), Pharma Packaging ...
(Date:9/16/2014)... Denmark , Sept. 16, 2014  Ascendis ... innovative TransCon technology to address significant unmet medical ... ongoing Phase 2 pediatric study to evaluate once-weekly ... deficiency, or GHD.  The full interim results will ... the GRS and IGF Society, being held October ...
(Date:9/16/2014)... 2014 RENU 28, the world's first and ... available for purchase in Australia and New Zealand in mid-August ... September 16th. The tour will make stops in Brisbane on ... the 18th, Sydney on the 20th, and Melbourne on the ... New Zealand and to educate people about the new product ...
Breaking Biology Technology:New Appointment to the Scientific Advisory Committee at Egenix, Inc. 2Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 2Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Global Wellness Company Hosts ASEA Australia Tour September 16-22 2
... of PCR reactions with Herculase enhanced DNA,polymerase ... ,Stratagene , Stratagene recently released Herculase ... that provides,superior performance in both routine and demanding ... exhibits greater fidelity than,commercial DNA polymerase blends, in ...
... ,Single-tube amplification method for high-throughput screening of HSV ... Peter Pingerelli ,Melanie Palmer Dwight DuBois ,Stratagene , ... , ff ,a single-tube ... Because,it is performed in a closed-tube system and requires ...
... developed for,highfidelity PCR , , Kirk B. Nielson ... Barbara McGowan * Holly Hogrefe ,Stratagene Cloning Systems, Inc. ... Precision PCR system,* to an expanding line of PCR ... mixture of Taq2000 and Pfu DNA polymerases and a ...
Cached Biology Technology:Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR,Performance 2Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR,Performance 3Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR,Performance 4Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR,Performance 5Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR,Performance 6Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR,Performance 7Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR,Performance 8HSVision Molecular Beacon Detection Module Rapidly Detects Herpes Simplex,Virus DNA 2HSVision Molecular Beacon Detection Module Rapidly Detects Herpes Simplex,Virus DNA 3HSVision Molecular Beacon Detection Module Rapidly Detects Herpes Simplex,Virus DNA 4High-Fidelity PCR with a Novel Polymerase Mixture 2High-Fidelity PCR with a Novel Polymerase Mixture 3High-Fidelity PCR with a Novel Polymerase Mixture 4High-Fidelity PCR with a Novel Polymerase Mixture 5High-Fidelity PCR with a Novel Polymerase Mixture 6High-Fidelity PCR with a Novel Polymerase Mixture 7High-Fidelity PCR with a Novel Polymerase Mixture 8High-Fidelity PCR with a Novel Polymerase Mixture 9High-Fidelity PCR with a Novel Polymerase Mixture 10High-Fidelity PCR with a Novel Polymerase Mixture 11
Recombinant Mouse Wnt-3a...
... There are at least 20 structurally ... of the TGF-beta superfamily. BMPs were originally ... bone formation. They are also involved in ... organs. BMPs regulate the growth, differentiation, chemotaxis ...
RABBIT ANTI HUMAN TRRAP (CT) Immunogen: Recombinant C-terminal kinase-related domain of human TRRAP....
RABBIT ANTI HUMAN CHYMOTRYPSIN...
Biology Products: