Navigation Links
ORNL fundamental discovery casts enzymes in new light
Date:11/9/2011

OAK RIDGE, Tenn. -- A tree outside Oak Ridge National Laboratory researcher Pratul Agarwal's office window provided the inspiration for a discovery that may ultimately lead to drugs with fewer side effects, less expensive biofuels and more.

Just as a breeze causes leaves, branches and ultimately the tree to move, enzymes moving at the molecular level perform hundreds of chemical processes that have a ripple effect necessary for life. Previously, protein complexes were viewed as static entities with biological function understood in terms of direct interactions, but that isn't the case. This finding, published today in PLoS Biology, may have enormous implications.

"Our discovery is allowing us to perhaps find the knobs that we can use to improve the catalytic rate of enzymes and perform a host of functions more efficiently," said Agarwal, a member of the Department of Energy laboratory's Computer Science and Mathematics Division.

Making this discovery possible was ORNL's supercomputer, Jaguar, which allowed Agarwal and co-author Arvind Ramanathan to investigate a large number of enzymes at the atomistic scale.

The researchers found that enzymes have similar features that are entirely preserved from the smallest living organism bacteria -- to complex life forms, including humans.

"If something is important for function, then it will be present in the protein performing the same function across different species," Agarwal said. "For example, regardless of which company makes a car, they all have wheels and brakes."

Similarly, scientists have known for decades that certain structural features of the enzyme are also preserved because of their important function. Agarwal and Ramanathan believe the same is true for enzyme flexibility.

"The importance of the structure of enzymes has been known for more than 100 years, but only recently have we started to understand that the internal motions may be
'/>"/>

Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Putting trees on farms fundamental to future agricultural development
2. Ecological scientists assess the fundamentals of animal behavior
3. Lack of access to evidence-based HIV prevention and care is a fundamental violation of human rights
4. Researchers identify a fundamental process in lysosomal function and protein degradation
5. Mouse work: New insights on a fundamental DNA repair mechanism
6. Phytoplankton cell membranes challenge fundamentals of biochemistry
7. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
8. Discovery of new gene could improve efficiency of molecular factories
9. Lung regeneration closer to reality with new discovery by Weill Cornell Medical College researchers
10. Discovery announced in Science represents new paradigm in the way drugs can be manufactured
11. Discovery illuminates elusive proton channel gene in dinoflagellates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... conclusive evidence that the source of a unique rhythmic ... called the "bio-duck," is the Antarctic minke whale ( ... personnel in the 1960s who thought it sounded like ... various locations in the Southern Ocean, but its source ... 2013, an international team of researchers deployed acoustic tags ...
(Date:4/23/2014)... the likelihood of an accurate group decision increases with ... when a collective faces a variety of factors ... University researchers report that smaller groups actually tend to ... excessively focused on only certain pieces of information. , ... known about collective intelligence, or the "wisdom of crowds," ...
(Date:4/23/2014)... The shale gas boom has transformed the energy ... locations, it could cause conflict among the energy ... resources, say researchers. They add that degraded water ... adequate safeguards. The feature article appears in the ... , Meagan S. Mauter and colleagues point out ...
Breaking Biology News(10 mins):Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3How to avoid water wars between 'fracking' industry and residents 2
... January 11, 2010 Why do some people like to ... hand, taking the opposite tack by buying insurance to reduce ... Hebrew University of Jerusalem and two Asian universities say the ... team set out to tackle the long-standing question in economic ...
... standards to help ensure the quality and enhance the ... and a variety of functional foods are being proposed ... internationally recognized compendium of quality standards for food ingredients. ... breast milk and commonly added to infant formula, and ...
... Ohio Blocking the function of an enzyme in the ... nerve cells from dying after a stroke, new research suggests. ... that the tocotrienol form of vitamin E, an alternative to ... acids that eventually kill neurons. The Ohio State University ...
Cached Biology News:Why do people 'play the longshot' and buy insurance? It's in our genes 2Quality and safety of infant formulas, functional foods enhanced by new standards 2Quality and safety of infant formulas, functional foods enhanced by new standards 3Study reveals how one form of natural vitamin E protects brain after stroke 2Study reveals how one form of natural vitamin E protects brain after stroke 3
(Date:1/15/2014)... Biotechnology Company, Limited ("TaiGen") today announced that they have ... pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ® ... Turkey and other members of ... for the treatment of bacterial infections including those caused ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
(Date:1/14/2014)... Jan. 14, 2014  3D Communications, a leading provider of strategic communications ... and media events in the United States ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 EquitiesIQ, ... Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical ... serve the wound care market. , Free report download: ... restructured with a seasoned management team and Board, which ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... REDWOOD CITY, Calif., March 4 Maxygen, Inc.,(Nasdaq: ... the development of,improved protein drugs, today announced changes ... president in charge of global,business development and U.S. ... business officer. In addition, the company announced the,pending ...
... new independent non-executive directors added to Board with ... ... appointed independent non-executive Chairman, BRISBANE, Australia, March 4 ... John Lee and Robert Williamson to the Company,s Board as,independent ...
... Biosciences,(Nasdaq: MATK ) announced today that life,sDHA, its ... heart health, is available in new So,Good Omega DHA ... selling soymilk brand. Available in original or vanilla flavor, ... major retailers throughout,Canada., "So Good Omega DHA Soymilk ...
Cached Biology Technology:Maxygen Announces Management Changes 2Progen Expands Board of Directors 2Progen Expands Board of Directors 3Progen Expands Board of Directors 4Canada's Best-Selling Soymilk Now Available with Martek's life'sDHA 2Canada's Best-Selling Soymilk Now Available with Martek's life'sDHA 3
... Blocker Array II can be used ... against various proteins and sera that are ... carriers. The array contains spots for 19 ... Application: Determination of antibody crossreactivity and species ...
... Tecans new HydroFlex platform provides excellent ... range of 96-well format applications, including ... protein arrays, and vacuum filtration-to-waste, such ... outstanding on-line control features set new ...
... and Accurate Results Laser Capture Microdissection ... sensitivity and accuracy of molecular assays by ... and multi-cellular structures isolated from whole tissue ... microdissection-developed in 1996 at the National Institutes ...
...
Biology Products: