Navigation Links
ORNL fundamental discovery casts enzymes in new light
Date:11/9/2011

OAK RIDGE, Tenn. -- A tree outside Oak Ridge National Laboratory researcher Pratul Agarwal's office window provided the inspiration for a discovery that may ultimately lead to drugs with fewer side effects, less expensive biofuels and more.

Just as a breeze causes leaves, branches and ultimately the tree to move, enzymes moving at the molecular level perform hundreds of chemical processes that have a ripple effect necessary for life. Previously, protein complexes were viewed as static entities with biological function understood in terms of direct interactions, but that isn't the case. This finding, published today in PLoS Biology, may have enormous implications.

"Our discovery is allowing us to perhaps find the knobs that we can use to improve the catalytic rate of enzymes and perform a host of functions more efficiently," said Agarwal, a member of the Department of Energy laboratory's Computer Science and Mathematics Division.

Making this discovery possible was ORNL's supercomputer, Jaguar, which allowed Agarwal and co-author Arvind Ramanathan to investigate a large number of enzymes at the atomistic scale.

The researchers found that enzymes have similar features that are entirely preserved from the smallest living organism bacteria -- to complex life forms, including humans.

"If something is important for function, then it will be present in the protein performing the same function across different species," Agarwal said. "For example, regardless of which company makes a car, they all have wheels and brakes."

Similarly, scientists have known for decades that certain structural features of the enzyme are also preserved because of their important function. Agarwal and Ramanathan believe the same is true for enzyme flexibility.

"The importance of the structure of enzymes has been known for more than 100 years, but only recently have we started to understand that the internal motions may be
'/>"/>

Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Putting trees on farms fundamental to future agricultural development
2. Ecological scientists assess the fundamentals of animal behavior
3. Lack of access to evidence-based HIV prevention and care is a fundamental violation of human rights
4. Researchers identify a fundamental process in lysosomal function and protein degradation
5. Mouse work: New insights on a fundamental DNA repair mechanism
6. Phytoplankton cell membranes challenge fundamentals of biochemistry
7. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
8. Discovery of new gene could improve efficiency of molecular factories
9. Lung regeneration closer to reality with new discovery by Weill Cornell Medical College researchers
10. Discovery announced in Science represents new paradigm in the way drugs can be manufactured
11. Discovery illuminates elusive proton channel gene in dinoflagellates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... their own "antifreeze" proteins to survive in the ... effect, researchers funded by the National Science Foundation ... inside their bodies resist melting even when temperatures ... be an undesirable consequence of the evolution of ... of Oregon doctoral student Paul Cziko, who led ...
(Date:9/23/2014)... the body forms new tissues during the healing ... each other. For years, scientists believed this communication ... Carnegie Mellon University and the University of Pittsburgh ... is equally if not more crucial. The ... Proceedings of the National Academy of Sciences ...
(Date:9/23/2014)... Ill. Scientists have scoured cow rumens and termite ... cell walls for the production of next-generation biofuels, but ... in the human lower intestine, researchers report. , Their ... the National Academy of Sciences , is the first ... microbes in the human gut can digest fiber, breaking ...
Breaking Biology News(10 mins):Antifreeze proteins in Antarctic fish prevent both freezing and melting 2Antifreeze proteins in Antarctic fish prevent both freezing and melting 3The mechanics of tissue growth 2Search for better biofuels microbes leads to the human gut 2Search for better biofuels microbes leads to the human gut 3
... Forget what you know about how diseases are diagnosednew research ... FASEB Journal ( http://www.fasebj.org ) details a noninvasive ground-breaking ... before symptoms can be seen using traditional methods. Even better, ... that they may be reversed before any permanent damage can ...
... available in Spanish . Scientists funded by ... a low-calorie diet or a very low-calorie diet not only ... study may be the first to demonstrate the interaction between ... researcher, Simin Nikbin Meydani, is director of the Jean Mayer ...
... you to overeat? These labels certainly appear to make ... than it really does. These findings were presented at ... showed that people who ate organic cookies labeled as "organic" ... same cookies that had no label, according to Jenny Wan-Chen ...
Cached Biology News:New tool helps scientists 'see' molecular signals of eye disease before symptoms arise 2Less is more when restraining calories boosts immunity 2
(Date:9/23/2014)... September 23, 2014 Erlab , ... personnel since 1968 and Burdinola, supplier of laboratory furniture ... new filtered fume hood. , By integrating ... hood, Burdinola will now offer an innovative solution utilizing ... range of chemicals, best-in-class detection technology, and communication for ...
(Date:9/23/2014)... , Sept. 23, 2014 ... the "Proteomics Markets for Research and IVD ... Technologies)" report to their offering. ... for proteomics applications, both in their research use ... proteins, including the study of the structure and ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 For the fifth ... Inc. 500|5000 list of the fastest-growing companies. , “We’re ... acknowledged yet again by Inc. Magazine,” ExakTime CEO Tony Pappas ... list by posting a three-year growth rate of 61 percent ... that time by more than 40 percent. , Pappas cited ...
(Date:9/23/2014)... 23, 2014 Follow us ... steady popularity the world over, due to its ... in the marketplace is expected to come from ... developing countries. Several sub-Saharan countries in the African ... already implemented genetically engineered crop production strategies. Rising ...
Breaking Biology Technology:Erlab Partners with Burdinola to Deliver an Innovative Filtered Fume Hood 2Proteomics Markets for Research and IVD Applications (Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays, Other Technologies) 2Proteomics Markets for Research and IVD Applications (Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays, Other Technologies) 3Proteomics Markets for Research and IVD Applications (Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays, Other Technologies) 4ExakTime Makes Inc. 5000 List for the Fifth Time 2Rising Focus on Food Security Spurs Growth in the Global Agricultural Biotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Rising Focus on Food Security Spurs Growth in the Global Agricultural Biotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Rising Focus on Food Security Spurs Growth in the Global Agricultural Biotechnology Market, According to New Report by Global Industry Analysts, Inc. 4
... in Science," ASU Foundation Professor and Director of the Origins Project ... public modern physicist, has been chosen as the 2011 Book of ... Feynman is one of the most famous physicists of the second ... science to the people, taking time to explain in simple terms ...
... licensed from Yale University a new clinical diagnostic assay ... patients with melanoma to identify a subset of those ... lymph nodes, have a 40% risk of recurrence of ... testing method that enables measurement of protein biomarkers in ...
... NEOG ) announces the following Webcast: ... Thursday, December 22, 2011 @ 11:00 a.m. ET ... the Internet -- Simply log on to the web at ... Neogen Corporation, +1-800-234-5333. If you are unable to ...
Cached Biology Technology:Book on Richard Feynman nets honors for Arizona State professor 2Book on Richard Feynman nets honors for Arizona State professor 3HistoRx Licenses Melanoma Assay from Yale University 2
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
... The Dyad Disciple thermal cycler is a ... may also be operated independently, using a ... of interchangeable Alpha units (sample-holder, heat-pump assemblies), ... as the Chromo4 real-time detector. Peltier heat ...
...
I-Ab MHC Class II...
Biology Products: