Navigation Links
OHSU discovery may someday lead to prevention and treatment of sudden infant death syndrome
Date:2/16/2012

Researchers at Oregon Health & Science University have discovered that brain cells commonly thought to play a supporting role actually are critically important for the growth of brainstem neurons responsible for cardiorespiratory control. The discovery has profound implications for the prevention and treatment of SIDS (Sudden Infant Death Syndrome), the leading cause of death in children aged one month to one year.

The new discovery is published online in Neuroscience: http://www.sciencedirect.com/science/article/pii/S0306452212000358

In their study, the OHSU team looked at glial cells, non-neuronal cells of the brain, and found that they very potently regulate growth of nerve cells in the brainstem. In fact, the glial cells actually inhibit the growth of brainstem neurons and may be as important for establishing neuronal networks as neurotrophic factors, a family of proteins essential for brain growth and survival. The OHSU study is the first to find that glial cells inhibit nerve cell growth.

"Previous research has shown that a common feature of the brains of SIDS babies is a dramatically increased number of glial cells," said Agnieszka Balkowiec, M.D., Ph.D., principal investigator and associate professor of integrative biosciences in the OHSU School of Dentistry. "Based on the results of our new study, the increase in glial cells in SIDS babies could be the cause of a compromised growth of brainstem neurons that control the cardiorespiratory function and, ultimately, cause death."

The new study also shows that glial cells direct the growth of brainstem neurons caused by BDNF (Brain-Derived Neurotrophic Factor), another molecule found by the Balkowiec lab to play an important role in cardiorespiratory control.

"Our study shows that the picture is more complex than we had previously thought," said Balkowiec. "A better understanding of interactions between BDNF and glial cells could play a significant role in the development of treatment for SIDS, high blood pressure, and other disorders with a deficient cardiorespiratory control."


'/>"/>

Contact: Sydney Clevenger
clevenge@ohsu.edu
Oregon Health & Science University
Source:Eurekalert

Related biology news :

1. Notre Dame researchers report fundamental malaria discovery
2. Discovery of plant nourishing gene brings hope for increased crop seed yield and food security
3. Discovery could help stem smoking-related diseases
4. Georgetown researchers lead discovery expected to significantly change biomedical research
5. New horned dinosaur announced nearly 100 years after discovery
6. Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology
7. UGA discovery changes how scientists think about plant cell wall formation
8. Discovery of therapeutic peptides affecting mitochondria
9. ORNL fundamental discovery casts enzymes in new light
10. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
11. Discovery of new gene could improve efficiency of molecular factories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... Feb. 1, 2017  Central to its deep ... advances worldwide, The Japan Prize Foundation today announced ... have pushed the envelope in their respective fields ... Three scientists are being recognized with the 2017 ... not only contribute to the advancement of science ...
(Date:1/26/2017)... 26, 2017  Crossmatch, a leading provider of security ... aimed at combatting fraud, waste and abuse in assistance ... the Action on Disaster Relief conference in ... UN agencies and foreign assistance organizations throughout ... abuse are a largely unacknowledged problem in the foreign ...
(Date:1/24/2017)...  It sounds simple and harmless—an electronic sensor ... signs and alerts parents on their smart phones ... drops. But pediatric experts argue that such devices ... evidence of medical benefits, especially to healthy babies. ... parents of healthy babies, promising peace of mind ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... Kurzlehrgang mit Fokus auf ... Poster legt metaproteomische Analyse des Darm-Mikrobioms bei Säuglingen dar   ... ... Yoav Peretz , Scientific Director bei ImmuneCarta, einen ... zum Nachweis intrazellulärer Zytokine bei adoptiven Zelltherapie-Studien im Rahmen ...
(Date:2/18/2017)... ... 2017 , ... A leader in science-based, age-fighting skincare products, ... is proud to introduce its Age-Defying Night Cream, NeriumAD™ Formula, Age-Defying Day Cream, ... Hong Kong. The luxury skincare products contain innovative ingredients that fight the signs ...
(Date:2/17/2017)... , February 17, 2017 ... "Biomarkers Market by Product (Consumables, Service), Type (Safety, ... (Diagnostics Development, Drug Discovery and Development, Disease-Risk) - ... market is projected to reach USD 53.34 Billion ... growing at a CAGR of 13.8% during the ...
(Date:2/17/2017)... Feb. 17, 2017  If only one in ... a mutation-conferring resistance to chemotherapy, thousands of cancer ... has focused on finding these mutations in ever-smaller ... circulating tumor DNA in blood — to guide ... Unfortunately, however, detecting these genetic anomalies ...
Breaking Biology Technology: