Navigation Links
OHSU discovery may someday lead to prevention and treatment of sudden infant death syndrome
Date:2/16/2012

Researchers at Oregon Health & Science University have discovered that brain cells commonly thought to play a supporting role actually are critically important for the growth of brainstem neurons responsible for cardiorespiratory control. The discovery has profound implications for the prevention and treatment of SIDS (Sudden Infant Death Syndrome), the leading cause of death in children aged one month to one year.

The new discovery is published online in Neuroscience: http://www.sciencedirect.com/science/article/pii/S0306452212000358

In their study, the OHSU team looked at glial cells, non-neuronal cells of the brain, and found that they very potently regulate growth of nerve cells in the brainstem. In fact, the glial cells actually inhibit the growth of brainstem neurons and may be as important for establishing neuronal networks as neurotrophic factors, a family of proteins essential for brain growth and survival. The OHSU study is the first to find that glial cells inhibit nerve cell growth.

"Previous research has shown that a common feature of the brains of SIDS babies is a dramatically increased number of glial cells," said Agnieszka Balkowiec, M.D., Ph.D., principal investigator and associate professor of integrative biosciences in the OHSU School of Dentistry. "Based on the results of our new study, the increase in glial cells in SIDS babies could be the cause of a compromised growth of brainstem neurons that control the cardiorespiratory function and, ultimately, cause death."

The new study also shows that glial cells direct the growth of brainstem neurons caused by BDNF (Brain-Derived Neurotrophic Factor), another molecule found by the Balkowiec lab to play an important role in cardiorespiratory control.

"Our study shows that the picture is more complex than we had previously thought," said Balkowiec. "A better understanding of interactions between BDNF and glial cells could play a significant role in the development of treatment for SIDS, high blood pressure, and other disorders with a deficient cardiorespiratory control."


'/>"/>

Contact: Sydney Clevenger
clevenge@ohsu.edu
Oregon Health & Science University
Source:Eurekalert

Related biology news :

1. Notre Dame researchers report fundamental malaria discovery
2. Discovery of plant nourishing gene brings hope for increased crop seed yield and food security
3. Discovery could help stem smoking-related diseases
4. Georgetown researchers lead discovery expected to significantly change biomedical research
5. New horned dinosaur announced nearly 100 years after discovery
6. Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology
7. UGA discovery changes how scientists think about plant cell wall formation
8. Discovery of therapeutic peptides affecting mitochondria
9. ORNL fundamental discovery casts enzymes in new light
10. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
11. Discovery of new gene could improve efficiency of molecular factories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... (NASDAQ: AWRE ), a leading supplier of biometrics software and ... ended December 31, 2015.  --> ... million, an increase of 61% compared to $4.3 million in the ... 2015 was $2.6 million compared to $0.2 million in the fourth ... Higher revenue and operating income in the fourth quarter of ...
(Date:2/4/2016)... 2016 The field of Human Microbiome ... most popular hubs of the biotechnology industry. While ... studies of human microbiota, have garnered a lot ... microbiome space has literally exploded in terms of ... report focuses on biomedical aspects of research, development, ...
(Date:2/3/2016)... 2016 http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ... "Emotion Detection and Recognition Market by ... Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020" report ... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the addition of ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 2016 --> ... (OTCQB: PSID), a life sciences company focused on ... subsidiary, which markets the Caregiver® FDA-cleared non-contact thermometer, ... January 2016, including entering into agreements with five ... growth, and establishing several near-term pipeline opportunities. ...
(Date:2/11/2016)... ... 11, 2016 , ... Reichert Technologies, which has created advanced ... the highest level of accuracy and quality with the addition of two new ... Refractometer. Accurate, reliable and tough enough for the most demanding applications, these ...
(Date:2/11/2016)... ... February 11, 2016 , ... Global Stem Cells ... in Quito, Ecuador. The new facility will provide advanced protocols and state-of-the-art techniques ... the world. , The new GSCG clinic is headed by four prominent ...
(Date:2/10/2016)... 2016 Early-career researchers from ... , Uganda and Yemen ... and nutrition   Indonesia , Nepal ... and Yemen are being honored for their accomplishments ... also celebrated for mentoring young women scientists who are pursuing careers in ...
Breaking Biology Technology: