Navigation Links
OHSU discovery may lead to new treatment for ALS
Date:7/18/2012

PORTLAND, Ore. Researchers at Oregon Health & Science University School of Dentistry have discovered that TDP-43, a protein strongly linked to ALS (Amyotrophic Lateral Sclerosis) and other neurodegenerative diseases, appears to activate a variety of different molecular pathways when genetically manipulated. The findings have implications for understanding and possibly treating ALS and neurodegenerative diseases such as Alzheimer's and Parkinson's.

ALS affects two in 100,000 adults in the United States annually and the prognosis for patients is grim.The new discovery is published online in G3: Genes, Genomes, Genetics (and the July 2012 print issue of G3).

Using a fruit fly model, the OHSU team genetically increased or eliminated TDP-43 to study its effect on the central nervous system. By using massively parallel sequencing methods to profile the expression of genes in the central nervous system, the team found that the loss of TDP-43 results in widespread gene activation and altered splicing, much of which is reversed by rescue of TDP-43 expression. Although previous studies have implicated both absence and over expression of TDP-43 in ALS, the OHSU study showed little overlap in the gene expression between these two manipulations, suggesting that the bulk of the genes affected are different.

"Our data suggest that TDP-43 plays a role in synaptic transmission, synaptic release and endocytosis," said Dennis Hazelett, Ph.D., lead author of the study. "We also uncovered a potential novel regulation of several pathways, many targets of which appear to be conserved."


'/>"/>

Contact: Sydney Clevenger
clevenge@ohsu.edu
Oregon Health & Science University
Source:Eurekalert

Page: 1

Related biology news :

1. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
2. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
3. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
4. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
5. Discovery offers insight into treating viral stomach flu
6. Breast cancer risk gene discovery fast tracked by new technology
7. Tales from the crypt lead researchers to cancer discovery
8. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
9. Stomata development in plants unraveled -- a valuable discovery for environmental research
10. Discovery reveals chromosomes organize into yarns
11. Bacteria discovery could lead to antibiotics alternatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... The Granite Club, Canada,s ... announced it has implemented a state-of-the-art access and security ... and staff, while restricting access to authorized users only. ... IMID Access system because it has the perfect combination ... in addition to unparalleled security," said James DiRenzo ...
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... Protection Agency (EPA) has awarded nearly $2.5 million ... eight key environmental areas: monitoring and control of ... hazardous waste monitoring, water infrastructure, homeland security, nanotechnology ... received "proof of concept" awards from EPA, and ...
... -- Tufts University,s School of Arts and Sciences has ... that will house a Collaborative Cluster in Genome Structure ... will bring together experts in such areas as genome ... engineering to focus on "genome to organism" research to ...
... Researchers from Mahidol University have developed a rapid, ... The related report by Munkongdee et al, "Rapid ... the May 2010 issue of The Journal of ... caused by a genetic defect in the production of ...
Cached Biology News:EPA awards small businesses to develop new environmental technologies 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 3
(Date:3/25/2015)... , March 25, 2015  The Technology Association ... leading association dedicated to the promotion and economic advancement ... announced Streamline Health as one of its Top 40 ... TAG will recognize this prestigious group at the 2015 ... the Cobb Galleria Centre. TAG,S Top 40 ...
(Date:3/25/2015)... -- FDNA®, the pioneer in computer-aided dysmorphology ... allowing geneticists around the globe to access Facial ... devices. Face2Gene® facilitates detection of facial dysmorphic features and ... up-to-date genetic references. The date of the release coincides ... Salt Lake City, UT , where ...
(Date:3/25/2015)... NEW YORK , March 25, 2015   ... highly specialized targeted investor and business development conferences exclusively ... that it is launching the Biotech CEO Summit. ... think-tank style meeting that brings together biotech industry leaders ... responsible growth and innovation while reaping the rewards of ...
(Date:3/25/2015)... DNA Spectrum , a leading consumer ... product earlier this year. This consumer offering is designed ... currently stands. It does so through analysis of customers’ ... affect physical fitness. Once this analysis is completed, myDNA ... effects with the client's body profile and the latest ...
Breaking Biology Technology:Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 3Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 4FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2Biotech CEO Summit to Bring Key Biotech Leaders Together in Industry Brain Trust 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 3DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 4
... , , , EMERYVILLE, ... company, announced today that new research data will be delivered ... on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco, CA ... a multi-institutional collaborative in vitro study of Adamas, ...
... , , ... MASI ), the inventor of Pulse CO-Oximetry(TM) and ... its Radical-7 and Rad-57 Pulse CO-Oximeters have achieved Airworthiness ... certification is a fundamental milestone that allows the U.S. ...
... LAUSANNE, Switzerland, September 3 Debiopharm Group, SA,(Debiopharm), ... focus on the development of prescription drugs that ... Sciences Award, to Dr Lluis,Quintana-Murci from the Institut ... the emerging field of evolutionary genetics of,infection. Funded ...
Cached Biology Technology:Adamas Pharmaceuticals to Present Data on Triple Combination Antiviral Drug Therapy for Drug-Resistant Influenza at 2009 ICAAC Annual Meeting 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 3Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 4The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 2The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 3
... LC Sciences provides a comprehensive epitope ... microarrays synthesized on Paraflo microfluidic chips ... biosensor development. This comprehensive service includes ... assays using sample(s) provided by you, ...
... ,Schistosomal glutathione-S-transferase (GST) is commonly ... proteins in E. coli (1). The GSTTag ... production and in some cases the solubility ... a soluble, properly folded form, GSTTag fusion ...
... The Bio-Stack is compatible with ... systems. Speed, ease of use and ... routine microplate process. When used with ... reagent dispenser, the Bio-Stacks small footprint ...
... and versatile automated strip washer which can ... manifold. This breakthrough design allows for independent ... for overfill washing and overflow protection in ... of fitting dispense and aspirate tubes into ...
Biology Products: