Navigation Links
OHSU Vollum Institute research gives new insight into how antidepressants work in the brain
Date:11/8/2013

ts, we have laid the foundation for the design of new molecules with better therapeutic profiles and, hopefully, with fewer deleterious side effects," said Gouaux.

Gouaux's latest dopamine transporter research is also important because it was done using the molecule from fruit flies, a dopamine transporter that is much more similar to those in humans than the bacteria models that previous studies had used.

The dopamine transporter article was one of two articles Gouaux had published in today's edition of Nature. The other article also dealt with a modified amino acid transporter that mimics the mammalian neurotransmitter transporter proteins targeted by antidepressants. It gives new insights into the pharmacology of four different classes of widely used antidepressants that act on certain transporter proteins, including transporters for dopamine, serotonin and noradrenaline. The second paper in part was validated by findings of the first paper in how an antidepressant bound itself to a specific transporter.

"What we ended up finding with this research was complementary and mutually reinforcing with the other work so that was really important," Gouaux said. "And it told us a great deal about how these transporters work and how they interact with the antidepressant molecules."

Gouaux's discoveries over the years in neurotransmission have established him as one of the top investigators in his field. His research has important implications for understanding the mechanisms of not just antidepressants, but also drugs used for the treatment of a wide range of psychiatric and neurological diseases.


'/>"/>

Contact: Todd Murphy
murphyt@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Diabetes Research Institute develops oxygen-generating biomaterial
2. Space research institute honors Sen. Hutchison with Pioneer Award
3. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
4. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
5. Cary Institute Hydrofracking Forum
6. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
7. Scripps Research Institute scientists develop antidote for cocaine overdose
8. NJIT, Chinas Bengbu Glass Institute sign agreement for R&D, training
9. Merkin Family Foundation to fund next generation of Broad Institute scientists
10. TGen leads new National Institutes of Health study of brain tumors
11. CUNY Energy Institute battery system could reduce buildings electric bills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... Dec. 9, 2014  Valencell, a leader in performance ... a staggering demand from its licensees for highly accurate, ... is not solely coming from fitness and health sectors, ... "A wearable is only as useful as the ... the ultimate driver in long-term mass consumer adoption of ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an ... connective tissue that enhances care coordination among social service ... client-level information; earned a second $1 million grant from ... seniors aging in community and; will be recognized as ... th 4-6p. CIE San Diego today ...
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... The GARBAN project, drawn up by Navarre University, will ... and hepatitis. , The School of Engineering at Navarre ... in Gipuzkoa (CEIT) have launched an advanced biochemical analysis ... diseases, accelerate their diagnosis and identify new therapeutic targets ...
... long time that only 2% -- 3% of human DNA ... -- often referred to as junk DNA -- consists of ... DNA, and then reinserted into a new spot in the ... retroelements. Retroviruses can insinuate themselves into the host's DNA in ...
... magnetic "nanoparticles" to DNA and then cut these "DNA ... self-assembling devices for future computers. , Findings are detailed ... Journal of the American Chemical Society. The paper was ... Albena Ivanisevic, an assistant professor of biomedical engineering and ...
Cached Biology News:Analysis Of Human Genome To Predict The Development Of Illnesses 2Chimp genome reveals a retroviral invasion 2Chimp genome reveals a retroviral invasion 3Purdue researchers use enzyme to clip 'DNA wires' 2Purdue researchers use enzyme to clip 'DNA wires' 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... have an advantage in the media. A new study ... published in the journal of Israel,s National Security College, ... this arena too. , "Information warfare" plays ... sometimes more so than conventional weapons. Therefore, the information ...
... discovered a way to use an ancient life form to ... systems that may be surprisingly simple to build compared to ... tiny, single-celled marine life forms have existed for at least ... the life in the oceans, but they also have rigid ...
... Inc. (Nasdaq: ANDS ) announced today that ... Thursday, April 23, 2009, after the U.S. financial markets ... Thursday, April 23, 2009 at 5:00 p.m. Eastern Daylight ... and highlights and to provide an update on its ...
Cached Biology Technology:Information warfare in the 21st century: Ideas are sometimes stronger than bombs 2Ancient diatoms lead to new technology for solar energy 2Anadys Pharmaceuticals to Report First Quarter 2009 Financial Results 2
Request Info...
...
... potent inhibition of RNase A-type ribonucleases Product ... of nonhuman origin that binds noncovalently and ... A, B, and C). It does not ... U2, or CL3. QIAGEN RNase Inhibitor inhibits ...
Request Info...
Biology Products: