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OHSU Knight Cancer Institute researcher wins prestigious early-career award
Date:7/3/2014

a clinical trial to test ruxolitinib in patients with chronic neutrophilic leukemia (CNL) that is driven by mutations in a gene called colony stimulating factor 3 receptor (CSF3R) is soon to open.

"Jeffrey Tyner's work is making a significant contribution to the advancement of personalized cancer medicine. His approach makes it possible to achieve new discoveries in months that used to take decades," said Brian Druker, M.D., director of the Knight Cancer Institute. "It is gratifying to see his contributions recognized with an AAAS Martin and Rose Wachtel Cancer Research Award."

Tyner's methodology also forms the backbone of Beat AML, a pioneering collaboration launched in 2013 between The Leukemia & Lymphoma Society (LLS) and the Knight Cancer Institute to vastly accelerate development of treatments for patients with acute myeloid leukemia (AML). AML is a particularly devastating blood cancer with less than 25 percent of newly diagnosed patients surviving beyond five years. It causes more than 10,000 deaths a year in the United States, and treatment options largely have not changed in the past 30 years.

Beat AML creates a profile of the possible genetic drivers of AML by conducting a deep genomic sequencing analysis of participating AML patients' samples. As information from the samples is analyzed by the Knight Cancer Institute's bioinformatics team to determine potentially relevant mutations, researchers simultaneously test the response of patients' leukemia cells to different drugs and combinations of drugs. This dual process on patient samples better equips scientists to confirm that they have correctly identified a genetic driver of the disease. It not only speeds progress in understanding AML, but more efficiently determines ways to stop the disease and block potential recurrence.

Tyner said his lab will likely deploy a similar model for drug development for other types of cancer in the future. "It's an honor to have th
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Contact: Elisa Williams
willieli@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert  

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