Navigation Links
OGI's investment in cytognomix contributes to the Shannon Human Splicing Pipeline's success
Date:4/29/2013

TORONTO, ON, April 29, 2013 - Ontario Genomics Institute (OGI) congratulates Cytognomix on the success of the Shannon Human Splicing Pipeline, which was recently purchased by the National Cancer Institute (NCI) in the U.S. In 2009, OGI invested in Cytognomix through its Pre-commercialization Business Development Fund (PBDF).

Understanding the wealth of data generated by next-generation sequencing is essential to determining which mutations are clinically significant. Cytognomix's Shannon pipeline assesses the millions of variants of unknown significance detected in cancer genetic testing by predicting mRNA splicing abnormalities. This technology improves accuracy and ease of data interpretation, saving time and reducing mistakes.

Investigators at NCI are using the Shannon pipeline to evaluate somatic and germline variants observed in tumor genome next generation sequences for their potential effects on splicing. According to Dr. Mike Nickerson, Cancer and Inflammation Program, NCI, the analytic tool is being applied to evaluate a variety of variants which can be difficult to interpret in terms of their effects on protein function. Analysis of variants for potential effects on splicing provides a tool to distinguish deleterious mutations from passenger variants and generates hypotheses that can be experimentally evaluated using PCR of reverse-transcribed tumor RNA.

"Cytognomix's Shannon pipeline is resolving significant data interpretation issues in cancer research," said Mark Poznansky, CEO, OGI. "It is rewarding to see the companies we invest in succeed and grow. OGI's investment provided Cytognomix with early stage funding, which allowed them to take important next steps toward bringing their products to market."

According to Peter Rogan, CEO of Cytognomix, "Interpreting gene variants of unknown clinical significance is one of the most important challenges in human genomics. While much effort has been focused on gathering existing knowl
'/>"/>

Contact: Christine Beyaert
cbeyaert@ontariogenomics.ca
416-673-6597
Ontario Genomics Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Microbiologists can now measure extremely slow life
3. American Society of Plant Biologists honors early career women scientists
4. Interventional radiologists see significant symptom relief in MS patients
5. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
6. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
7. University of Toronto biologists predict extinction for organisms with poor quality genes
8. UC Riverside plant cell biologist receives top scientific honor
9. Biologists turn back the clock to understand evolution of sex differences
10. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
11. Anthropologist finds explanation for hominin brain evolution in famous fossil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... can take up residence in and on the human ... symptom, according to new research at Washington University School ... healthy individuals carry about five types of viruses on ... Central Biology . The study is the first comprehensive ... people. , The research was conducted as part ...
(Date:9/16/2014)... interaction between viruses, bacteria, and their environment is ... collaboration between Matthew Sullivan, associate professor in the ... Biology and Steven Hallam from the University of ... are drivers of nutrient and energy cycles that ... is changing, so are the environments these bacteria ...
(Date:9/16/2014)... 2014 Schizophrenia is associated with increased rates and ... research suggests that the relationship between schizophrenia and smoking ... use nicotine to self-medicate symptoms and cognitive impairment associated ... the current issue of Biological Psychiatry , sheds ... level of nicotine receptors in the brain was lower ...
Breaking Biology News(10 mins):Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3New research decodes virus-host interactions in ocean dead zones 2New research decodes virus-host interactions in ocean dead zones 3Smoking and schizophrenia linked by alterations in brain nicotine signals 2
... For two weeks in March, some of the greatest names ... take part in public discussions on how fundamental discoveries in ... understanding of life and civilization -- and our grasp of ... & Life of Beginnings," this one-of-a-kind program was organized by ...
... Global climate rapidly shifted from a relatively ice-free world ... 34 million years ago. What happened? What changed? ... a new perspective on the nature of changing climatic ... and has important implications for predicting future climate changes. ...
... CLEMSON, SCIn areas of the U.S. where golfers can ... traffic, and frost can wreak havoc on healthy greens ... Creeping bentgrass ( Agrostis stolonifera var. palustris Huds. ), ... is often preferred because of its year-round green color, ...
Cached Biology News:World's top minds to celebrate 'the birth and life of beginnings' 2World's top minds to celebrate 'the birth and life of beginnings' 3World's top minds to celebrate 'the birth and life of beginnings' 4CO2 drop and global cooling caused Antarctic glacier to form 2This grass is still greener 2
(Date:9/16/2014)... , Sept. 16, 2014 In preparation for ... -based cybersecurity company focused on authentication and SSO ... support the ability to generate a OTP through the ... a pioneer of user-based RFID authentication, 2FA,s solutions have ... access, for many years. RFID authentication is broadly deployed ...
(Date:9/15/2014)...   Global Science & Technology, Inc. (GST) ... services for satellite and weather systems, was awarded ... (OASIS) from the General Services Administration (GSA) Federal ... the government best-value solutions for complex professional service ... Pool 4. The OASIS SB award has an ...
(Date:9/15/2014)... when a patient has sepsis, a life-threatening condition in ... -- often too fast for antibiotics to help. A ... by a team at Harvard,s Wyss Institute for Biologically ... sepsis. , "Even with the best current treatments, ... least 30 percent of the time," said Mike Super, ...
(Date:9/15/2014)... BOISE, Idaho , Sept. 15, 2014  iVinci ... and only comprehensive Patient Revenue Management system, branded as ... The company also announced the launch of a new ... Portal that provides an easy and convenient way for ... plans for balances owed by them and their families. ...
Breaking Biology Technology:2FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3
... Almost everybody knows the University of Wisconsin-Madison ... But a new study has produced figures to back ... in the University Research Park , located three ... university research. And the concentration of these innovative firms, ...
... has heard of identity theft (IDT), yet unless you have ... high risk. An alarming figure is that over half of ... place of business, employer, or other entity (not-for-profit or local, ... are required under one or more federal and state laws ...
... Madison-based National Stem Cell Bank has announced it ... of California-San Francisco , giving it 13 of the 21 ... Donley, executive director of the WiCell Research Institute , ... optimistic that it eventually will have all 21 federally approved ...
Cached Biology Technology:Impact of research park firms pegged at $680M 2Identity theft: The business time bomb 2Identity theft: The business time bomb 3Identity theft: The business time bomb 4Nation's only stem cell bank will receive UC-San Francisco cell line 2
... NeuroLog System is a compact, versatile & modular ... of purposes including: Intracellular, Extracellular, Transducer & ... The NeuroLog Case & Power Supply unit (NL900D) ... Modules are not only powered by this unit, ...
Rat Epidermal Keratinocytes (REK) (>500,000 cells)...
... Precision Model 410 is a four-channel general purpose ... small signals from sources which may have a ... channel consists of a high gain/low noise amplifier, ... and an output offset control. A control knob ...
Porcine Coronary Artery Endothelial Cells (PCAEC) (>500,000 cells)...
Biology Products: