Navigation Links
OGI invests in drug discovery at InDanio Bioscience
Date:10/19/2010

The InDanio screening system can be used, for example, to functionally characterize 'orphan' receptors those for which their natural ligands or specific function are unknown and thus qualify them as potential targets for drug discovery. The system can also be used to screen compound libraries in order to identify and refine potential new drugs that target NR proteins.

NRs are found inside cells and are responsible for sensing the presence of hormones and other molecules. They regulate the expression in the cell of a number of genes involved in homeostatic, metabolic and reproductive processes. NRs regulate the expression in the cell of a number of processes, and they also represent an important and successful class of drug targets implicated in some of the most prevalent diseases, including immune disorders, obesity, diabetes and cancer. A study four years ago determined that one seventh of drugs approved by the U.S. Food and Drug Administration (FDA) target nuclear receptors, and the top ten selling NR-based drugs combined represent worldwide annual sales of over USD $16 billion. Although many NRs have been targeted successfully, most of them have not been, and one third of them are still orphans.

InDanio was founded by Dr. Henry Krause, a professor in the Banting and Best Department of Medical Research at the University of Toronto, and Dr. Jens Tiefenbach, a post-doctoral fellow working with Dr. Krause and is based on the IP portfolio generated by their research.

"The OGI investment will allow InDanio to characterize the function of ill-understood members of the NR family and thus form the basis for establishing commercial partnerships to further characterize such receptors and develop drugs targeting them," commented Dr. Paul Chipperton, member of the InDanio board of directors and CEO of Profound Medical. "With a more efficient and comprehensive approach to probing the NR receptors, there is a tremendous opportunity to develop
'/>"/>

Contact: Alastair Harris-Cartwright
aharriscartwright@ontariogenomics.ca
416-673-6582
Ontario Genomics Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. JPMorgan Chase & Co., Invests $25,000 to Support Bring Me A Books San Jose Elementary School Library Initiative
2. Finland invests €1.85 million in pan-European infrastructure for biomedical research
3. University of Plymouth invests in dental research
4. NIGMS invests in scientific Grand Opportunities with Recovery Act funds
5. Texas invests record $3.5 million in startup cofounded by UTs Mauro Ferrari
6. T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
7. Research breakthrough hailed on the anniversary of gene discovery
8. Discovery of a cell that suppresses the immune system
9. Census of Marine Life celebrates decade of discovery
10. Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
11. Biofuel from inedible plant material easier to produce following enzyme discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... habitats and trees and not just asphalt and recreation ... University of Colorado Boulder study. , Working on class ... benefits for youth, according to a paper published in ... is one of the first of its kind to ... settings and stress. , "Many schools already offer stress ...
(Date:7/22/2014)... lunch box and you,re likely to find that the lunches ... the findings of a study conducted by researchers at the ... and in the Department of Public Health and Community Medicine ... published online ahead of print in the Journal of ... by senior author Jeanne Goldberg, Ph.D., R.D., a professor at ...
(Date:7/22/2014)... , July 22, 2014 NXT-ID, Inc., (NXTD: ... m-commerce market, announces its next generation smart wallet, Wocket™, will ... oriented television show that airs on the History ... NewsWatch regularly features top technology products and ... on the History Channel (6:00-6:30am ET/PT) and the ...
Breaking Biology News(10 mins):Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3Room for improvement in elementary school children's lunches and snacks from home 2NXT-ID's Next Generation Wocket Smart Wallet to be Featured on NewsWatch, Airing on History Channel, FYI Network and ION Network 2NXT-ID's Next Generation Wocket Smart Wallet to be Featured on NewsWatch, Airing on History Channel, FYI Network and ION Network 3
... Anthony D. Rosato, PhD, a professor in the department ... has received a Fulbright Senior Research Award ... particles at the University of Salerno, in Fisciano, Italy. ... Rosato recently presented an invited seminar there entitled "Microstructure ...
... The American Society for Biochemistry and Molecular Biology ... nonprofit,s annual awards. Another winner was announced earlier this ... society,s annual meeting April 9-13 in Washington, D.C., are ... Medical Institute investigator Axel T. Brunger won the inaugural ...
... ones making exciting scientific discoveries these days. Two middle ... who are reporting the first glimpse of the innermost ... certain antibiotics and anti-cancer agents so that those substances ... journal Biochemistry . The student co-authors of the ...
Cached Biology News:NJIT professor receives Fulbright to study at University of Salerno 2American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists 2American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists 3American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists 4
(Date:7/22/2014)... Md. , July 22, 2014  United ... today that it will release its second quarter ... July 29, 2014. United Therapeutics will ... 2014, at 9:00 a.m. Eastern Time.  The teleconference ... dialing 1-970-315-0533.  A rebroadcast of the teleconference will ...
(Date:7/22/2014)... Biofeedback – When a behavioral problem ... medication to best treat it can become a matter ... electroencephalography (EEG) can help predict which medicine will offer ... adverse drug events. , The article “Medication Prediction ... issue of the journal Biofeedback offers evidence that quantitative ...
(Date:7/21/2014)... Lawrence Livermore National Laboratory ... and Las Positas College (LPC) recently established a ... hands-on training for veterans, officials recently announced. , ... Positas is designed to help veterans develop ... careers, and establishes a pipeline of qualified candidates ...
(Date:7/21/2014)... Syracuse University,s College of Arts and Sciences has ... of stainless nanoparticles. , Mathew M. Maye, associate ... $360,000 grant from the National Science Foundation (NSF). ... stainless alloy nanostructures, the results of which may ... batteries. , Maye,s approach is novel, ...
Breaking Biology Technology:Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3Syracuse University chemist to use NSF grant to study materials chemistry, nanoscience 2
... Wisconsin Entrepreneurs Conference, held at the Hyatt Regency Milwaukee, ... on starting a company, learn how to improve revenue ... state. , ,However, at the conference luncheon on Tuesday, ... industry representatives by the guest speakers: inspiration. During ...
... roller-coaster ride of ups and downs during the past 15 ... worlds brightest scientists. They are tantalized by the enormous potential ... curing diseases of many kinds. , ,One group, consisting of ... the Waisman Center at UW-Madison and Mirus ...
... heard the drumbeat about IT project failure rates. Youve probably ... of sponsor support, poor requirements and scope definition, lack of ... apparent in all of this hand wringing is the real ... are technology based. For each one, the source is the ...
Cached Biology Technology:Celebrating Wisconsins entrepreneurial spirit 2Celebrating Wisconsins entrepreneurial spirit 3Researchers report major advance in gene therapy technique 2Researchers report major advance in gene therapy technique 3Researchers report major advance in gene therapy technique 4Analog people in the digital revolution 2Analog people in the digital revolution 3
Mouse monoclonal [050-04] to C2 ( Abpromise for all tested applications). entrezGeneID: 717 SwissProtID: P06681...
C/EBPalpha Antibody Shipping Temperature: Cold Storage Temperature: -20C...
...
AADAC Immunogen: AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: