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OGI genomics researchers awarded $23 million
Date:5/9/2011

f genetic changes that underlie disease," commented Dr. McKerlie. "This funding from Genome Canada supports a leading role for Canada within an international program to understand the function of all 20,000 genes in the genome and builds on the successes of the original NorCOMM project started in 2006. NorCOMM focused on developing and distributing a library of mouse embryonic stem cell lines carrying single gene trapped or targeted mutations across the mouse genome. This new NorCOMM2 project will let us put that resource to work to understand the function of those genes in normal biology and disease."

The team, consisting of Canadian and UK researchers, will study the developmental problems and diseases that occur in 280 mouse models over the next three years. Each of the mouse models contain one abnormal or mutated gene and the team will ascertain the effect of each mutation to identify the function of the gene, and determine whether that gene, or the protein it produces, could be a drug target or used in a diagnostic test.

The third project, with a budget of nearly $10 million, is led by Drs. Sachdev Sidhu, Associate Professor, and Charles Boone, Professor, Banting and Best Department of Medical Research, University of Toronto, and will work towards developing a process and infrastructure for efficient and large-scale production of synthetic antibody reagents to target cancer and other devastating diseases.

This project will ultimately yield candidate therapeutic antibodies for commercialization by targeting in excess of 100 secreted proteins that are associated with cancer. The market for antibody therapeutics is expected to reach $26 billion this year.

"This funding will allow our team, consisting of leading cancer biologists from the Toronto research community, to generate and validate hundreds of antibodies against a host of cancer-associated targets," commented Dr. Sidhu. "These antibodies will be powerful tools for di
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Contact: Alastair Harris-Cartwright
aharriscartwright@ontariogenomics.ca
416-673-6582
Ontario Genomics Institute
Source:Eurekalert

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