Navigation Links
Nutritional supplement improves cognitive performance in older adults, study finds
Date:2/6/2014

Tampa, FL (Feb. 6, 2014) Declines in the underlying brain skills needed to think, remember and learn are normal in aging. In fact, this cognitive decline is a fact of life for most older Americans.

Therapies to improve the cognitive health of older adults are critically important for lessening declines in mental performance as people age. While physical activity and cognitive training are among the efforts aimed at preventing or delaying cognitive decline, dietary modifications and supplements have recently generated considerable interest.

Now a University of South Florida (USF) study reports that a formula of nutrients high in antioxidants and other natural components helped boost the speed at which the brains of older adults processed information.

The USF-developed nutritional supplement, containing extracts from blueberries and green tea combined with vitamin D3 and amino acids, including carnosine, was tested by the USF researchers in a clinical trial enrolling 105 healthy adults, ages 65 to 85.

The two-month study evaluated the effects of the formula, called NT-020, on the cognitive performance of these older adults, who had no diagnosed memory disorders.

Those randomized to the group of 52 volunteers receiving NT-020 demonstrated improvements in cognitive processing speed, while the 53 volunteers randomized to receive a placebo did not. Reduced cognitive processing speed, which can slow thinking and learning, has been associated with advancing age, the researchers said.

The study, conducted at the USF Health Byrd Alzheimer's Institute, appears in the current issue of Rejuvenation Research (Vol. 17 No. 1, 2014). Participants from both groups took a battery of memory tests before and after the interventions.

"After two months, test results showed modest improvements in two measures of cognitive processing speed for those taking NT-020 - compared to those taking placebo," said Brent Small, PhD, a professor in USF's School of Aging Studies. "Processing speed is most often affected early on in the course of cognitive aging. Successful performance in processing tasks often underlies more complex cognitive outcomes, such as memory and verbal ability."

Blueberries, a major ingredient in the NT-020 formula, are rich in polyphenols, a type of antioxidant containing a polyphenolic, or natural phenol substructure.

"The basis for the use of polyphenol-rich nutritional supplements as a moderator of age-related cognitive decline is the age-related increase in oxidative stress and inflammation," said study co-principal investigator Paula C. Bickford, PhD, a professor in the Department of Neurosurgery and Brain Repair, USF Health Morsani College of Medicine, and senior research career scientist at the James A. Haley Veterans' Hospital in Tampa, FL. "Non-vitamin polyphenols are the most abundant modulators of oxidative stress and inflammation in our diet. NT-020 is 95 percent polyphenols."

In several preclinical trials, researchers gave aging laboratory rats NT-020 to see if it boosted memory and other cognitive performance by promoting the health of neurons in the aging brain. Those studies demonstrated that NT-020 promoted the growth of stem cells in the brain, produced an overall rejuvenating effect, benefitted animals with simulated stroke, and led to better cognitive performance.

The researchers plan future clinical trials with longer intervention periods so that the optimal time for taking the formula may be better understood. The researchers speculated that if the study had included participants cognitively less healthy, or those with memory impairments, they may have observed "more robust findings."

"In the future, having markers of oxidative stress and inflammation, as well as brain-based measures of functioning, may allow us to identify the manner by which this compound, as well as others, may influence functioning," they concluded.

The NT-020 formula was patented by the University of South Florida, in partnership with the James A. Haley Veterans' Hospital, and licensed to Natura Therapeutics, Inc. The supplement is commercially available as NutraStem.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)
Source:Eurekalert  

Related biology news :

1. Asias first under-1-roof Nutritional Research Centre set up in Singapore
2. TV ads nutritionally unhealthy for kids, study finds
3. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
4. Do food blogs serve as a source of nutritionally balanced recipes?
5. Pizza perfect! A nutritional overhaul of junk food and ready-meals is possible
6. New research shows that potatoes provide one of the best nutritional values per penny
7. Nutritional quality at fast-food restaurants still needs improvement
8. Fertilizers could help tackle nutritional deficiency in African country, researchers say
9. Which nutritional factors help preserve muscle mass, strength and performance in seniors?
10. CRN assesses current state of scientific research for nutritional supplements
11. Fish oil added to yogurt may help consumers meet daily nutritional requirements
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nutritional supplement improves cognitive performance in older adults, study finds
(Date:3/7/2017)... , March 7, 2017   HireVue , the ... global companies identify the best talent, faster, today announced ... Sales Officer (CSO) and Diana Kucer as ... out a seasoned executive team poised to drive continued growth ... on a year of record bookings in 2017. ...
(Date:3/2/2017)... 2, 2017 Australian stem cell and regenerative ... has signed an agreement with the Monash Lung Biology ... Discovery Institute and Department of Pharmacology at Monash University, ... preclinical study to support the use of Cymerus™ mesenchymal ... Asthma is a chronic, long term lung ...
(Date:2/27/2017)... , Feb. 27, 2017   Strategic Cyber Ventures ... it has led a $3.5 million investment in  Polarity ... Strategic Cyber Ventures is DC based and is led ... Hank Thomas . Ron Gula , also a ... also participated in this series A round of funding. ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... , March 22, 2017   iSpecimen ®, ... announced that Doctors Pathology Service (DPS), a ... of the United States , has ... Delaware Health Information Network (DHIN) to make human ... The novel program, announced in 2015 as ...
(Date:3/22/2017)... March 22, 2017   VWR ... of product and service solutions to laboratory ... has acquired EPL Archives, Inc., an international ... the entire regulated product research, development and ... storage and ancillary services. EPL Archives is ...
(Date:3/22/2017)... ... March 21, 2017 , ... ... more than tripling its goal and raising over $30,000 in the first 40 ... grows nutritious veggies & herbs fast, easy, and affordably, anywhere. , “Simply add ...
(Date:3/22/2017)... Iowa (PRWEB) , ... March 22, 2017 , ... March ... is time for another green revolution, one that utilizes technological innovation in smart, sustainable ... tangible aspects of life such as aesthetics and environmental stability. This paper is the ...
Breaking Biology Technology: