Navigation Links
Nutrition influences metabolism through circadian rhythms, UCI study finds
Date:12/19/2013

Irvine, Calif., Dec. 19, 2013 A high-fat diet affects the molecular mechanism controlling the internal body clock that regulates metabolic functions in the liver, UC Irvine scientists have found. Disruption of these circadian rhythms may contribute to metabolic distress ailments, such as diabetes, obesity and high blood pressure.

There's good news, though. The researchers also discovered that returning to a balanced, low-fat diet normalized the rhythms. This study reveals that the circadian clock is able to reprogram itself depending on a diet's nutritional content which could lead to the identification of novel pharmacological targets for controlled diets.

UC Irvine's Paolo Sassone-Corsi, the Donald Bren Professor of Biological Chemistry and one of the world's leading researchers on the genetics of circadian rhythms, led the study, which appears in Cell.

Circadian rhythms of 24 hours govern fundamental physiological functions in virtually all organisms. The circadian clocks are intrinsic time-tracking systems in our bodies that anticipate environmental changes and adapt themselves to the appropriate time of day. Changes to these rhythms can profoundly influence human health. Up to 15 percent of people's genes are regulated by the day-night pattern of circadian rhythms, including those involved with metabolic pathways in the liver.

A high-fat diet reprograms the liver clock through two main mechanisms. One blocks normal cycles by impeding the clock regulator genes called CLOCK:BMAL1. The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR-gamma. Previously implicated in inflammatory responses and the formation of fatty tissue, this factor oscillates with a high-fat diet.

It's noteworthy, Sassone-Corsi said, that this reprogramming takes place independent of the state of obesity; rather, it's solely dependent upon c
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fish oil added to yogurt may help consumers meet daily nutritional requirements
2. Poll shows strong voter support for school nutrition standards
3. Researchers unveil new assessment for diagnosing malnutrition
4. Carnivorous plants rely on the services and wastes of a symbiotic ant for nutrition
5. Washington University receives $8 million to lead international childhood malnutrition effort
6. Wiley-Blackwell launches new open-access journal: Food Science & Nutrition
7. CRN assesses current state of scientific research for nutritional supplements
8. Nutrition tied to improved sperm DNA quality in older men
9. A mother’s nutrition--before pregnancy--may alter the function of her children’s genes
10. World experts enlist to help Malaysia mitigate problem of poorer nutrition as incomes rise
11. Malaysia to battle nutrition transition problem emerging worldwide: More income, poorer diet choices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... Today, farming often involves transporting crops long distances ... corn, Northwest cherries and other produce when they are ... fossil fuel needed to move food that contributes to ... journal Biogeosciences provides a detailed account of how carbon ...
... Water, an increasingly critical resource in the world, factors ... of "Turfgrass Water Conservation," a widely used reference, was ... and water conservation has made significant gains. Now ... the reference book to bring readers, attention to the ...
... Seeking to measure the U.S. first responder community,s ... local levels, the National Institute of Standards and Technology ... will distribute documentary standards to first responders as part ... October 2011. The pilot will help OLES gauge whom ...
Cached Biology News:Carbon hitches a ride from field to market 2Carbon hitches a ride from field to market 3Carbon hitches a ride from field to market 4How to manage turfgrass while conserving water 2It's your standard pilot project: NIST to offer documentary standards to first responders 2
(Date:12/19/2014)... In contrast to traditional LED lights where the ... uses proprietary LED technology to incorporate their spectra in ... is critical in low proximity installations. The Valoya L-series ... lifetime which is up to four times longer than ... cost was clearly higher when compared to traditional fluorescent ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 With only ... time special on Sartorius Biohit products . The ... mLINE pipettes, Picus Electronic Pipette Trade-in Program, and free ... and Safety officers around the world. They are ideal ... Other features include:, ,     Full volume range ...
(Date:12/19/2014)... Dec. 18, 2014 Egenix, Inc. is pleased to ... Chairman of the Board, to succeed Donald Fresne ; ... will continue as a member of the Board.  In recognition ... to the company over almost twenty years, the Board designated ... of Directors has established a Search Committee to find a ...
(Date:12/19/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company ... announced the results of its annual general meeting of ... year in Relmada,s history and it set the stage ... Sergio Traversa , chief executive officer of Relmada. "Over ... human resource and clinical development objectives that position Relmada ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... International, Inc. (OTCQX: DATA), a technology and services company ... industry, today announced the Company,s selection as a 2011 ... year. "Being once again recognized as ... dedication DATATRAK and its employees have to bringing a ...
... In the computer displays of medical equipment in ... a major role. But a discovery reported from the ... crystal, which have been found to change their ordering ... very low concentrations of a particular bacterial lipid, might ...
... Switzerland, May 20, 2011 Syngenta announced today that ... facility adjacent to its existing research campus in Research ... is scheduled to begin in June 2011, will focus ... innovative solutions to growers across the world.   ...
Cached Biology Technology:DATATRAK Recognized as 2011 Crain's Leading EDGE Award Winner 2Liquid crystal droplets discovered to be exquisitely sensitive to an important bacterial lipid 2Liquid crystal droplets discovered to be exquisitely sensitive to an important bacterial lipid 3Syngenta to Invest in New U.S. Genetics Research Facility 2
... The Universal Vacuum System UVS400 is ... system. The UVS400 combines a refrigerated vapor ... in a single integrated unit. The easy-to-use, ... recovered solvent into single jar for easy ...
Abgene's ALTO-8 is the first automated decapper/capper for Abgene Twist-Lock tubes....
Request Info...
... Blood bank refrigerators: ,Each upright ... and superior 4C temperature uniformity for refrigerated ... HemaPro 2000 Surveillance Module for complete blood ... BBR37 are equipped with the HemaPro 101 ...
Biology Products: