Navigation Links
Nowhere to hide: New device sees bacteria behind the eardrum
Date:5/29/2012

CHAMPAIGN, lll. Doctors can now get a peek behind the eardrum to better diagnose and treat chronic ear infections, thanks to a new medical imaging device invented by University of Illinois researchers. The device could usher in a new suite of non-invasive, 3-D diagnostic imaging tools for primary-care physicians.

The research team, led by University of Illinois electrical and computer engineering professor Stephen Boppart, will publish their advance in the online Early Edition of the journal Proceedings of the National Academy of Sciences the week of May 28.

Ear infections are the most common conditions that pediatricians treat. Chronic ear infections can damage hearing and often require surgery to place drainage tubes in the eardrum, and problems can persist into adulthood.

Studies have found that patients who suffer from chronic ear infections may have a film of bacteria or other microorganisms that builds up behind the eardrum, very similar to dental plaque on unbrushed teeth. Finding and monitoring these so-called biofilms are important for successfully identifying and treating chronic ear infections.

"We know that antibiotics don't always work well if you have a biofilm, because the bacteria protect themselves and become resistant," Boppart said. "In the presence of a chronic ear infection that has a biofilm, the bacteria may not respond to the usual antibiotics, and you need to stop them. But without being able to detect the biofilm, we have no idea whether or not it's responding to treatment."

However, middle-ear biofilms are difficult to diagnose. A doctor looking through a standard otoscope sees only the eardrum's surface, not the bacteria-seeded biofilm lurking behind it waiting to bloom into infection. Invasive tests can provide evidence of a biofilm, but are unpleasant for the patient and cannot be used routinely.

The new device is an application of a technique called optical coherence tomography (OCT), a non-invasive imaging system devised by Boppart's group. It uses beams of light to collect high-resolution, three-dimensional tissue images, scanning through the eardrum to the biofilm behind it much like ultrasound imaging, but using light.

"We send the light into the ear canal, and it scatters and reflects from the tympanic membrane and the biofilm behind it," said graduate student Cac Nguyen, the lead author of the paper. "We measure the reflection, and with the reference light we can get the structure in depth."

The single scan is performed in a fraction of a second speed is a necessity for treating squirming tots and images a few millimeters deep behind the eardrum. Thus, doctors can see not only the presence of a biofilm, but also how thick it is and its position against the eardrum.

The paper marks the first demonstration of using the ear OCT device to detect biofilms in human patients. To test their device, the researchers worked with clinicians at Carle Foundation Hospital in Urbana, Ill., to scan patients with diagnosed chronic ear infections, as well as patients with normal ears. The device identified biofilms in all patients with chronic infections, while none of the normal ears showed evidence of biofilms.

"I think this is now a technology that allows physicians to monitor chronic ear infection, and examine better ways to treat the disease," said Boppart, who is also affiliated with the departments of bioengineering and internal medicine, the Institute for Genomic Biology, and the Beckman Institute for Advanced Science and Technology at the U. of I. "We can use different antibiotics and see how the biofilm responds."

Next, the researchers plan to investigate different ear pathology, particularly comparing acute and chronic infections, and will examine the relationship between biofilms and hearing loss. They hope that improved diagnostics will lead to better treatment and referral practices.

The researchers hope to make their device currently a hand-held prototype even more compact, easy to use, and low-cost. The device company Welch Allyn, based in Skaneateles Falls, N.Y., is a collaborator on the project, which was funded by the National Institutes of Health.

Boppart's group and its collaborators also will work to apply OCT imaging to other areas commonly examined by primary-care physicians. The ear-imaging device is the first in a suite of OCT-based imaging tools that the group plans to develop. Doctors could change the tip of the new OCT device, for example, to look at the eyes, mouth, nose, or skin.

"All the sites that a primary-care physician would look at, we can now look at with this more advanced imaging, " Boppart said. "With OCT, we are bringing to the primary-care clinic high-resolution 3-D digital imaging and being able to look at many different tissue structures in real-time, non-invasively and in depth."

"As medicine gets more high-tech, we want to give the front-line doctor the best technology to detect disease early," Boppart said.


'/>"/>

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Related biology news :

1. Nowhere to hide: Study finds future of Sumatran tigers threatened by human disturbances
2. Kount Receives Patent for Device Fingerprinting
3. Nanodiamond drug device could transform cancer treatment
4. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
5. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
6. NC State finds new nanomaterial could be breakthrough for implantable medical devices
7. Futronic Launches FS22 Fingerprint Access Control Device
8. BIO-key(R) Granted Patent for Trusted Biometric Device Security Solution
9. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
10. Device protects transplanted pancreatic cells from the immune system
11. Chemical found in medical devices impairs heart function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nowhere to hide: New device sees bacteria behind the eardrum
(Date:6/22/2016)... LOS ANGELES , June 22, 2016 ... of identity management and verification solutions, has ... cutting edge software solutions for Visitor Management, ... ® provides products that add functional ... The partnership provides corporations and venues with ...
(Date:6/20/2016)... , June 20, 2016 Securus ... justice technology solutions for public safety, investigation, corrections ... the prisons involved, it has secured the final ... (DOC) facilities for Managed Access Systems (MAS) installed. ... additional facilities to be installed by October, 2016. ...
(Date:6/9/2016)...  Perkotek an innovation leader in attendance control systems is proud to announce the ... employers to make sure the right employees are actually signing in, and to even ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ON (PRWEB) , ... June 23, 2016 , ... STACS ... DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as ... the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free ... and will showcase its product’s latest features from June 26 to June 30, ... poster on Disrupting Clinical Trials in The Cloud during the conference. DIA ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... the QB3@953 life sciences incubator to accelerate ... The shared laboratory space at QB3@953 was created to ... key obstacle for many early stage organizations - access ... the sponsorship, Amgen launched two "Amgen Golden Ticket" awards, ...
Breaking Biology Technology: