Navigation Links
Now in 3-D: Video of virus-sized particle trying to enter cell
Date:2/24/2014

ee-dimensional view of a virus-sized particle attacking a living cell, whereas electron microscopy is in two-dimensions and on dead cells," Yang said. "This gives us a completely new level of understanding."

In addition to simply viewing the particle's antics, the researchers can use the technique to map the contours of the cell surface, which is bumpy with proteins that push up from beneath the surface. By following the particle's movement along the surface of the cell, the researchers were able to map the protrusions, just as a blind person might use his or her fingers to construct an image of a person's face.

"Following the motion of the particle allowed us to trace very fine structures with a precision of about 10 nanometers, which typically is only available with an electron microscope," Welsher said. (A nanometer is one billionth of a meter and roughly 1000 times smaller than the width of a human hair.) He added that measuring changes in the speed of the particle allowed the researchers to infer the viscosity of the extracellular environment just above the cell surface.

The technology has potential benefits for both drug discovery and basic scientific discovery, Yang said. "We believe this will impact the study of how nanoparticles can deliver medicines to cells, potentially leading to some new lines of defense in antiviral therapies," he said. "For basic research, there are a number of questions that can now be explored, such as how a cell surface receptor interacts with a viral particle or with a drug."

Welsher added that such basic research could lead to new strategies for keeping viruses from entering cells in the first place.

"If we understand what is happening to the virus before it gets to your cells," said Welsher, "then we can think about ways to prevent infection altogether. It is like deflecting missiles before they get there rather than trying to control the damage once you've been hit."

To cre
'/>"/>

Contact: Catherine Zandonella
czandone@princeton.edu
Princeton University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FASEB announces winners of second annual Stand Up for Science video contest
2. Celldance 2013 video awards, the Cell Oscars, roll out tiny red carpet
3. 5 tips for a better Thanksgiving: A new video by the American Chemical Society
4. Immunity studies cross scientific and continental borders (video)
5. Cooking tips from Alton Brown: A new American Chemical Society video
6. Frost & Sullivan Honours Cognitec for Blazing Trails in the Face Biometrics Market with its FaceVACS-VideoScan Technology
7. The Chemistry of Fear: A new video from the American Chemical Society
8. 2 online science video pioneers combine to form new iBiology.org
9. Playing video games can boost brain power
10. Elsevier launches first video journal in gastrointestinal endoscopy
11. FASEB announces BioArt image and video competition winners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Salk Institute for Biological Studies, BGI, and other ... and reliability of the existing targeted gene correction ... which could significantly increased gene-correction efficiency in human ... online in Cell Stell Cell provides ... therapy. , The combination of stem cells and ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... the normal circumstances, astrocytes participate in normal ... and exhibit therapeutic and repairing effects on ... have found that nerve cells differentiated from ... reduced viability, which produces influences on subsequent ... General Hospital, Hebei United University, China demonstrated ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... COLUMBUS, Ohio From the paleolithic diet to the raw ... they believe our ancient ancestors ate. But some of these ... new book on the evolution of the use of food and ... can learn from what our ancestors ate, many of our more ...
... E. coli food poisoning outbreaks developed more ... trials because of lack of commercial interest. University of ... neutralises the toxin produced by E. coli , which ... The team of scientists Dr Adrienne Paton, Associate Professor ...
... to phase out nuclear power by 2022 has reopened an ... Japan, which is still coming to terms with events at ... the SETAC journal Environmental Toxicology and Chemistry adds ... using research from the Chernobyl disaster. The issue ...
Cached Biology News:An 'all natural' diet? There's no such thing 2An 'all natural' diet? There's no such thing 3Potential treatment for deadly E. coli disease 2
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) has ... Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... traces its roots in the latter half of ... went unexplored and unfulfilled for several decades owing ...
(Date:7/10/2014)... D.C., June 17, 2014 Using microscopic polymer ... specific gases, researchers at MIT,s Quantum Photonics Laboratory ... levels in the parts-per-billion range. Optical sensors are ... their high signal-to-noise ratio, compact, lightweight nature, and ... gas sensors had been developed before, the MIT ...
(Date:7/10/2014)... lithium-ion batteries that power our laptops and electric vehicles ... single charge with the help of a sponge-like silicon ... replace the graphite traditionally used in one of the ... the energy storage capacity of graphite. A paper describing ... published today in Nature Communications . , "Silicon ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... Dimensions , a Wisconsin data management firm, announced last ... the New York metro area by partnering with MailSurity ... company that develops paper scanning and data recognition technology, ... its software to process forms. , ,Parascript's software is ...
... rude noise somebody makes in a meeting after too ... population also knows that Enterprise Resource Planning isnt some ... single check to a vendor. , ,Im not out ... is apparently less obvious is that ERP systems dont ...
... provider of rich-media systems and software, is deploying its ... announced. , ,Sonic Foundry and media services provider ... Connect's new Virtual Law Viewer system for the ... MediaSite presentation recorders with the BxVideo RMXPRES hosting services, ...
Cached Biology Technology:Steering a project portfolio takes more than expensive software 2Steering a project portfolio takes more than expensive software 3Streaming video could make courtrooms into Internet conference calls 2
... product contains 5 ml Dynabeads Tosylactivated (4.5 ... (tosyl) reactive groups. For coupling of antibodies ... on initial coupling with covalent binding of ... sulphydryll groups (SH)) occurringovernight. Coupling reactions can ...
Carrier-Free Recombinant Human Flt-3/Flk-2 Ligand (Flt3/Flk2 Ligand, Flt3L, Flt3-L, Flk2L, Flk2-L) 100 ug...
... II inhibitor (IC50 = 59.2 M). ... H 32 O 13 MolWeight: ... RT CAS: ... Soluble to 100 mM in DMSO ...
NAP-2 (5C7)...
Biology Products: