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Now in 3-D: Video of virus-sized particle trying to enter cell
Date:2/24/2014

ee-dimensional view of a virus-sized particle attacking a living cell, whereas electron microscopy is in two-dimensions and on dead cells," Yang said. "This gives us a completely new level of understanding."

In addition to simply viewing the particle's antics, the researchers can use the technique to map the contours of the cell surface, which is bumpy with proteins that push up from beneath the surface. By following the particle's movement along the surface of the cell, the researchers were able to map the protrusions, just as a blind person might use his or her fingers to construct an image of a person's face.

"Following the motion of the particle allowed us to trace very fine structures with a precision of about 10 nanometers, which typically is only available with an electron microscope," Welsher said. (A nanometer is one billionth of a meter and roughly 1000 times smaller than the width of a human hair.) He added that measuring changes in the speed of the particle allowed the researchers to infer the viscosity of the extracellular environment just above the cell surface.

The technology has potential benefits for both drug discovery and basic scientific discovery, Yang said. "We believe this will impact the study of how nanoparticles can deliver medicines to cells, potentially leading to some new lines of defense in antiviral therapies," he said. "For basic research, there are a number of questions that can now be explored, such as how a cell surface receptor interacts with a viral particle or with a drug."

Welsher added that such basic research could lead to new strategies for keeping viruses from entering cells in the first place.

"If we understand what is happening to the virus before it gets to your cells," said Welsher, "then we can think about ways to prevent infection altogether. It is like deflecting missiles before they get there rather than trying to control the damage once you've been hit."

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Contact: Catherine Zandonella
czandone@princeton.edu
Princeton University
Source:Eurekalert

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