Navigation Links
Now in 3-D: Video of virus-sized particle trying to enter cell
Date:2/24/2014

Tiny and swift, viruses are hard to capture on video. Now researchers at Princeton University have achieved an unprecedented look at a virus-like particle as it tries to break into and infect a cell. The technique they developed could help scientists learn more about how to deliver drugs via nanoparticles which are about the same size as viruses as well as how to prevent viral infection from occurring.

The video reveals a virus-like particle zipping around in a rapid, erratic manner until it encounters a cell, bounces and skids along the surface, and either lifts offagain or, in much less time than it takes to blink an eye, slips into the cell's interior. The work was published in Nature Nanotechnology.

"The challenge in imaging these events is that viruses and nanoparticles are small and fast, while cells are relatively large and immobile," said Kevin Welsher, a postdoctoral researcher in Princeton's Department of Chemistry and first author on the study. "That has made it very hard to capture these interactions."

The problem can be compared to shooting video of a hummingbird as it roams around a vast garden, said Haw Yang, associate professor of chemistry and Welsher's adviser. Focus the camera on the fast-moving hummingbird, and the background will be blurred. Focus on the background, and the bird will be blurred.

The researchers solved the problem by using two cameras, one that locked onto the virus-like nanoparticle and followed it faithfully, and another that filmed the cell and surrounding environment.

Putting the two images together yielded a level of detail about the movement of nano-sized particles that has never before been achieved, Yang said. Prior to this work, he said, the only way to see small objects at a similar resolution was to use a technique called electron microscopy, which requires killing the cell.

"What Kevin has done that is really different is that he can capture a thr
'/>"/>

Contact: Catherine Zandonella
czandone@princeton.edu
Princeton University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FASEB announces winners of second annual Stand Up for Science video contest
2. Celldance 2013 video awards, the Cell Oscars, roll out tiny red carpet
3. 5 tips for a better Thanksgiving: A new video by the American Chemical Society
4. Immunity studies cross scientific and continental borders (video)
5. Cooking tips from Alton Brown: A new American Chemical Society video
6. Frost & Sullivan Honours Cognitec for Blazing Trails in the Face Biometrics Market with its FaceVACS-VideoScan Technology
7. The Chemistry of Fear: A new video from the American Chemical Society
8. 2 online science video pioneers combine to form new iBiology.org
9. Playing video games can boost brain power
10. Elsevier launches first video journal in gastrointestinal endoscopy
11. FASEB announces BioArt image and video competition winners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... -- Curemark LLC, a privately held drug research and ... III double blind, randomized, placebo-controlled clinical trial to examine ... children ages 3-8 with Autism. Previously, Curemark announced the ... clinical trial for CM-AT in children ages 3-8 with ... chymotrypsin. This new trial will help determine whether all ...
(Date:5/6/2015)... 2015 LifeBEAM, a developer of bio-sensing technology, ... today that they will expand their partnership in bio-sensing ... cycling helmet and the first joint project between the ... in order to give cyclists more style choices and ... and Lazer announced their plan to release a new ...
(Date:4/27/2015)... LAUDERDALE, Fla. , Apr. 27, 2015 ... of access control and security systems is pleased to ... the company as a consultant and member of its ... is widely known as a thought leader in ... Distance Learning Technology Group, and has published studies and ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... is a simple question, but there is no simple answer. ... mechanical properties that allow fish to perform their complex movements. ... PLOS Computational Biology , could provide insights in evolutionary biology ... movement and development of bio-inspired underwater vehicles. "If we ...
... prevent starvation at night, plants perform accurate arithmetic division. The ... a constant rate so that they run out almost precisely ... a fundamental biological process of such a sophisticated arithmetic calculation," ... Centre. Plants feed themselves during the day by using ...
... MA A new discovery about how cells move inside ... mechanisms such as the spread of cancer or the constriction ... School of Public Health (HSPH) and the Institute for Bioengineering ... form a barrier between the inside and the outside of ...
Cached Biology News:Northwestern researchers examine mechanical bases for the emergence of undulatory swimmers 2Plants do sums to get through the night 2Unexpected discovery of the ways cells move could boost understanding of complex diseases 2
(Date:5/21/2015)... 21, 2015  CytRx Corporation (NASDAQ: CYTR ... in oncology, today announced positive updated results from ... for the treatment of unresectable glioblastoma multiforme (GBM), ... multisite trial is designed to investigate the preliminary ... tumors have progressed following prior treatment with surgery, ...
(Date:5/21/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: RP) ... focused on the development of autologous cell therapies, ... International Society for Cellular Therapy (ISCT) on RepliCel,s ... in a Phase 1/2 clinical trial.  The presentation, ... 5:30 PM to 7:00 PM local time, will ...
(Date:5/20/2015)... , May 20, 2015 Veracyte, ... preliminary data demonstrating the ability of the company,s ... (IPF) from other interstitial lung diseases (ILDs) using ... classifier,s potential to help thousands of patients avoid ... in IPF diagnosis – a frequent challenge for ...
(Date:5/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ) has ... Market Outlook 2020 " report to their offering. ... regenerative medicine is expected to have huge marketing potential. ... in the growth of deregulated organs. Several therapeutic molecules ... to form new tissue or sometimes organ transplant is ...
Breaking Biology Technology:CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... , ... ... , , ... ...
... ... , ... (PRWEB) February 24, 2010 -- Model N , Inc., the leader in Revenue ... which extends the Model N Revenue Management Suite by allowing business users to rapidly ...
... ... ... ... ...
Cached Biology Technology:Wright State University Boonshoft School of Medicine and Miami Valley Hospital Announce Major New Initiative 2Wright State University Boonshoft School of Medicine and Miami Valley Hospital Announce Major New Initiative 3Wright State University Boonshoft School of Medicine and Miami Valley Hospital Announce Major New Initiative 4Wright State University Boonshoft School of Medicine and Miami Valley Hospital Announce Major New Initiative 5Wright State University Boonshoft School of Medicine and Miami Valley Hospital Announce Major New Initiative 6Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 2Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 3Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 4Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 5Appeal of Lawsuit by Former Officer Dismissed; Request for Sanctions Granted 2Appeal of Lawsuit by Former Officer Dismissed; Request for Sanctions Granted 3
... separations of DNA larger than 2, ... megabase pairs. This agarose has the highest gel strength of any electrophoresis agarose ... preparation ... ...
... System is a high-sensitivity peroxidase and ... kit is intended for use in ... two different antigens within the same ... diluted rabbit and mouse primary antibodies. ...
Liquid. PBS containing 10 mM NaN 3 . AVOID FREEZE/THAW CYCLES. Recognizes α1, 2, 3, 5, 6 and 7 subunits of 20S proteasome. ...
AVOID FREEZE/THAW CYCLES. Recognizes the UCP-2 protein....
Biology Products: