Now hear this( Deep in the ear 95 percent of the c...)

Deep in the ear, 95 percent of the cells that shuttle sound to the brain are big, boisterous neurons that, to date, have explained most of what scientists know about how hearing works. Whether a rare, whisper-small second set of cells also carry signals from the inner ear to the brain and have a real role in processing sound has been a matter of debate.

Now, reporting on rat experiments in the October 22 issue of Nature, a Johns Hopkins team says it has for what is believed to be the first time managed to measure and record the elusive electrical activity of the type II neurons in the snail-shell-like structure called the cochlea. And it turns out the cells do indeed carry signals from the ear to the brain, and the sounds they likely respond to would need to be loud, such as sirens or alarms that might be even be described as painful or traumatic.

The researchers say they've also discovered that these sensory cells get the job done by responding to glutamate released from sensory hair cells of the inner ear. Glutamate is a workhorse neurotransmitter throughout the nervous system and it excites the cochlear neurons to carry acoustic information to the brain.

"No one thought recording them was even possible," says Paul A. Fuchs, Ph.D., the John E. Bordley Professor of OtolaryngologyHead and Neck Surgery and co-director of the Center for Sensory Biology in the Johns Hopkins University School of Medicine, and a co-author of the report. "We knew the type II neurons were there and now at last we know something about what they do and how they do it."

Working with week-old rats, neuroscience graduate student Catherine Weisz removed live, soft tissue from the fragile cochlea and, guided by a powerful microscope, touched electrodes to the tiny type II nerve endings beneath the sensory hair cells. Different types of stimuli were used to activate sensory hair cells, allowing Weisz to record and analyze the resulting signals
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