Navigation Links
Novel treatment approach for bladder pain using a herpes simplex virus vector reported
Date:3/14/2013

New Rochelle, NY, March 14, 2013Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of dependency and serious adverse reactions. An alternative treatment strategy increases the levels of a naturally occurring painkiller in and around the nerves that deliver pain signals to the bladder. This new therapeutic approach is described in an article in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Human Gene Therapy website at http://www.liebertpub.com/hum.

Hitoshi Yokoyama, MD and colleagues from University of Pittsburgh School of Medicine (PA), Shinshu University School of Medicine (Matsumoto, Japan), and Diamyd (Pittsburgh, PA) describe a gene therapy technique in which they inject directly into the bladder wall the gene for enkephalin, an opioid compound produced by the human body. The gene is transported into the target cells via a herpes simplex virus vector that is incapable of replication.

In the article "Effects of Herpes Simplex Virus Vector-Mediated Enkephalin Gene Therapy on Bladder Overactivity and Nociception," the authors demonstrate high levels of enkephalin gene expression in the treated rats and significantly lower measures of pain compared to untreated animals when exposed to stimuli intended to induce bladder irritation. The researchers note that a similar gene therapy delivery vector carrying an enkephalin gene has been used in clinical studies in human patients to treat cancer-related pain, and was shown to be well tolerated and safe and to provide substantial pain relief.

"This is a very innovative application of Herpes Simplex Virus gene therapy in the treatment of a common and painful clinical problem that otherwise requires chronic use of narcotics," says James M. Wilson, MD, PhD, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related biology news :

1. Scientists discover novel chemical that controls cell behavior
2. BGI Tech develops novel Ultra-Deep de novo assembly solution for heterozygous genomes
3. Novel storage mechanism allows command, control of memory
4. Brown unveils novel wireless brain sensor
5. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
6. Novel coronavirus well-adapted to humans, susceptible to immunotherapy
7. Novel test streamlines testing for Huntington Disease
8. New tool for mining bacterial genome for novel drugs
9. Novel aptamer boosts T cell-based immune response to therapeutic vaccines
10. Novel technique reveals dynamics of telomere DNA structure
11. Novel approach to track migration of arctic-breeding avian species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel treatment approach for bladder pain using a herpes simplex virus vector reported
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), ... published by MarketsandMarkets, the market is expected to be worth USD 18.98 billion ... Continue Reading ... ...      (Logo: ...
(Date:3/22/2017)... March 21, 2017 Vigilant Solutions , ... law enforcement agencies, announced today the appointment of retired ... of public safety business development. Mr. Sheridan ... experience, including a focus on the aviation transportation sector, ... recent position, Mr. Sheridan served as the Aviation Liaison ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... 18, 2017 , ... Blood centers traditionally see a dangerous drop of blood ... a struggle for community blood centers as high schools are out and many frequent ... is teaming up with the South Texas Blood & Tissue Center ...
(Date:7/17/2017)... ... July 17, 2017 , ... The Academy of Model Aeronautics ... National Model Aviation Day will take place from 9 a.m. to 2 p.m. at ... activities for all ages. , Aviation Adventure Day will be packed with entertaining activities ...
(Date:7/17/2017)... ... July 17, 2017 , ... Panitch Schwarze Belisario & ... the BiG (Biomedical Innovation Group) annual meeting in China. , This year’s meeting, ... receptor T-cell) therapy, a rapidly developing highly personalized anti-cancer technology that involves removing ...
(Date:7/16/2017)... ... 16, 2017 , ... OHAUS Corporation, a leading worldwide manufacturer ... new line of Extreme Environment Shakers today. , Extreme Environment Shakers , OHAUS ... optimal cell growth such as cell cultures, solubility studies and extraction procedures. These ...
Breaking Biology Technology: