Navigation Links
Novel therapeutic strategy for colon cancer treatment
Date:6/10/2008

A team of scientists at the Genome Institute of Singapore (GIS), a research institute of the Asian city-state's Agency for Science, Technology and Research (A*STAR), and the University of California at San Francisco have developed a pharmacological approach to kill colon cancer cells.

Genetic and epigenetic defects in the signaling of a protein called Wnt/β-catenin, which is often found to be abnormally activated in human malignance, play important roles in colorectal cancer development. The team of scientists identified a gene, called DACT3, whose function is to inhibit Wnt/β-catenin, is often lost (or transcriptionally silenced) in colorectal cancer.

Apart from the findings on DACT3, they have also developed a pharmacological approach to restore the expression of DACT3, which results in the effective inhibition of Wnt/β-catenin massive death of colon cancer cells. Their discovery was published in Cancer Cell on June 9, 2008.

GIS Group Leader, Yu Qiang, Ph.D., said, "This work identifies a significant new regulator of the Wnt/β-catenin avenue for future colorectal cancer research."

Edison Liu, M.D., Executive Director of GIS, added, "This is indeed a very significant discovery. It suggests a novel therapy for colorectal cancer, an important step towards clinical treatment for the disease, which is one of the leading causes of death from tumours."

The team is now working with other A*STAR research institutes and industry partners for the development of potential drug candidates based on this technology.


'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1

Related biology news :

1. A survivor in Greenland: A novel bacterial species is found trapped in 120,000-year-old ice
2. Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
3. Glypican-3 gene function in regulating body size helps inform novel cancer treatments
4. Novel living system recreates predator-prey interaction
5. UD researchers discover novel gene toggles in worlds top food crop
6. Workman Lab characterizes novel regulator of chromosome function
7. Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants
8. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
9. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
10. Scientists outline novel approach to ecosystem management
11. Systems biologist finds novel solutions to fundamental biological problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... 2017 Research and Markets has announced the ... & Trends - Industry Forecast to 2025" report to their ... The Global ... CAGR of around 15.1% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... to 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market ... the next decade to reach approximately $14.21 billion by 2025. ... for all the given segments on global as well as regional ...
(Date:3/22/2017)... March 21, 2017 Optimove , ... by retailers such as 1-800-Flowers and AdoreMe, today ... Recommendations and Replenishment. Using Optimove,s machine learning algorithms, ... product and replenishment recommendations to their customers based ... predictions of customer intent drawn from a complex ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... ... July 26, 2017 , ... ... leading supplier of Semantic Graph Database technology for Knowledge Graphs, today announced ... connections within data. Gruff provides novice users and graph experts the ability to ...
(Date:7/26/2017)... ... July 25, 2017 , ... Avery Products Corporation, ... enable short-run digital printing, is proud to announce that it has won two ... online software available at avery.com/GHS . The products were recently honored with ...
(Date:7/26/2017)... ... July 25, 2017 , ... In this webinar , ... the considerations needed for designing ideal guide RNAs and DNA oligo or plasmid ... targeted double-strand breaks in genomic DNA has greatly simplified strategies for precise gene ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... targeted towards leveraging the years of diagnostic excellence by Mayo Clinic and the ... first product suite will be distributed through the Microsoft Azure platform and will ...
Breaking Biology Technology: