Navigation Links
Novel therapeutic strategy for colon cancer treatment
Date:6/10/2008

A team of scientists at the Genome Institute of Singapore (GIS), a research institute of the Asian city-state's Agency for Science, Technology and Research (A*STAR), and the University of California at San Francisco have developed a pharmacological approach to kill colon cancer cells.

Genetic and epigenetic defects in the signaling of a protein called Wnt/β-catenin, which is often found to be abnormally activated in human malignance, play important roles in colorectal cancer development. The team of scientists identified a gene, called DACT3, whose function is to inhibit Wnt/β-catenin, is often lost (or transcriptionally silenced) in colorectal cancer.

Apart from the findings on DACT3, they have also developed a pharmacological approach to restore the expression of DACT3, which results in the effective inhibition of Wnt/β-catenin massive death of colon cancer cells. Their discovery was published in Cancer Cell on June 9, 2008.

GIS Group Leader, Yu Qiang, Ph.D., said, "This work identifies a significant new regulator of the Wnt/β-catenin avenue for future colorectal cancer research."

Edison Liu, M.D., Executive Director of GIS, added, "This is indeed a very significant discovery. It suggests a novel therapy for colorectal cancer, an important step towards clinical treatment for the disease, which is one of the leading causes of death from tumours."

The team is now working with other A*STAR research institutes and industry partners for the development of potential drug candidates based on this technology.


'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1

Related biology news :

1. A survivor in Greenland: A novel bacterial species is found trapped in 120,000-year-old ice
2. Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
3. Glypican-3 gene function in regulating body size helps inform novel cancer treatments
4. Novel living system recreates predator-prey interaction
5. UD researchers discover novel gene toggles in worlds top food crop
6. Workman Lab characterizes novel regulator of chromosome function
7. Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants
8. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
9. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
10. Scientists outline novel approach to ecosystem management
11. Systems biologist finds novel solutions to fundamental biological problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
(Date:3/18/2016)... , March 18, 2016 --> ... of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and ... security companies in the border security market and the continuing ... and Europe has led visiongain to ... improved success. --> defence & security companies ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... City, Missouri (PRWEB) , ... May 04, 2016 , ... ... of Professional and Agricultural Sales. , Doug began his career at PBI-Gordon in ... since served in a wide variety of roles, ranging from customer service to national ...
(Date:5/3/2016)... ... May 03, 2016 , ... Morf Media ... compliance training platform on mobile devices, today released a new interactive Food ... Medical Devices. The course is essential for owners or operators of places of ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... addition of Dr. Nancy Gillett to its Board of Directors. Dr. Gillett recently ... as Corporate Executive Vice President and Chief Scientific Officer. A board-certified veterinary pathologist, ...
(Date:5/3/2016)... , May 3, 2016 - ... Developers and Producers of Those Competitor Biologics  ... Companies, Activities and Prospects ,  Who are ... companies? And what are their sales potentials? Discover, in ... see results, trends, opportunities and revenue forecasting. ...
Breaking Biology Technology: