Navigation Links
Novel technique changes lymph node biopsy, reduces radiation exposure
Date:1/13/2009

Information obtained from a new application of photoacoustic tomography (PAT) is worth its weight in gold to breast cancer patients.

For the first time, Lihong Wang, Ph.D., Gene K. Beare Distinguished Professor in the Department of Biomedical Engineering, with a joint appointment in Radiology, and Younan Xia, Ph.D., James M. McKelvey Professor in Biomedical Engineering, with a joint appointment in chemistry in Arts & Sciences, both at Washington University in St. Louis, have used gold nanocages to map sentinel lymph nodes (SLN) in a rat noninvasively using PAT. Wang's lab is the largest PAT lab in the world credited with the invention of super-depth photoacoustic microscopy, and Xia's lab invented the gold nanocages.

Their work can minimize invasive surgical lymph node biopsy procedures to determine if breast cancer has metastasized and reduce the patient's exposure to radioactivity. The nanocages also have the potential to serve as an alternative to chemotherapy to kill targeted cancers by heating them up.

From heat, to expansion, to sound and an image

PAT blends optical and ultrasonic imaging to give high-resolution images of the body that contain information about physiology or tissue function. Molecules already present in the body (endogenous molecules, as opposed to exogenous ones that are from outside the body), such as melanin, hemoglobin, or lipids, can be used as endogenous contrast agents for imaging. When light is shone on the tissue, the contrast agent absorbs the light, converts it to heat, and expands. This expansion is detected as sound and decoded into an image.

"Using pure optical imaging, it is hard to look deep into tissues at high resolution because light scatters. The useful photons run out of juice within 1mm," Wang explained. "PAT improves tissue transparency by 2-3 orders of magnitude because sound scatters less than light. This allows us to see through the tissue by listening t
'/>"/>

Contact: Lihong Wang
lhwang@wustl.edu
31-493-593-56152
Washington University in St. Louis
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel technique changes lymph node biopsy, reduces radiaiton exposure
2. Salk researchers develop novel glioblastoma mouse model
3. Novel technique for fluorescence tomography of tumors in living animals
4. Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
5. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
6. A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart
7. A novel target for therapeutics against Staph infection
8. Corn researchers discover novel gene shut-off mechanisms
9. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
10. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
11. GEN reports on novel tools for deciphering biological networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this market is ... Chemical sensors help in recording of patient data for ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... in the September 2007 issue of the Journal ... ARTICLE HIGHLIGHTS Renal transplant recipients genetic ... chemicals New anti-inflammatory compound discovered Thematic Review: Understanding how ... Renal transplant recipients genetic makeup does not negatively impact ...
... Pennsylvania researchers have designed a nanoscale system to ... external forces. By combining microfabricated cantilevers ... sensors, the study showed that cells respond to ... between cells and their environment. The study also ...
... new light on the health effects of exposure to dust ... Center disaster on September 11, 2001. The data, drawn from ... the 25,000 rescue and recovery workers enrolled in the Registry ... is 12 times what would be normally expected for the ...
Cached Biology News:Story ideas from the Journal of Lipid Research 2Story ideas from the Journal of Lipid Research 3Story ideas from the Journal of Lipid Research 4Story ideas from the Journal of Lipid Research 5Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces 2Survey finds elevated rates of new asthma among WTC rescue and recovery workers 2Survey finds elevated rates of new asthma among WTC rescue and recovery workers 3
(Date:1/22/2015)... 22, 2015   Cypher Genomics, Inc., the ... SQNM ), the leading molecular diagnostics ... generation noninvasive prenatal tests (NIPT). Through this agreement, ... Mantis™, to advance analysis of clinically-relevant fetal sub-chromosomal ...
(Date:12/25/2014)... 25, 2014 The report “Service Quality ... Type & Provider Type - Global Advancements, Worldwide Forecasts ... an in-depth analysis and forecasting of revenues. , ... 221 pages and in-depth TOC on “Service Quality Management ...
(Date:12/24/2014)... Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), today announced ... on May 4, 2015 (the "Annual Meeting"). Because ...
(Date:12/24/2014)... 2014 SoundConnect’s 2015 ... cutting edge communication technology, provide continued education and ... webinar series demonstrates online communication features and benefits; ... conferencing’s most innovative and powerful tools. , According ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... Early ... 2008 -, ... products company, announced today that it,has received a "positive opinion" recommending European ... chronic,renal failure and chemotherapy-induced anemia. Retacrit is a similar,biologic -- often referred ...
... WALNUT CREEK, CA It is better to be looked over ... of wisdom for genome data-miners of today. Data that ... to the discerning eye. Such is the case of a ... Institute (DOE JGI) of the massive backlog of microbial genome ...
... delicious when cooked in a white wine broth, but ... put in a pot: they stick to virtually all ... tenacity. , Northwestern University biomedical engineer Phillip B. Messersmith ... of the bonds; now he has produced a versatile ...
Cached Biology Technology:Hospira's Biosimilar Epoetin Retacrit(TM) Receives Positive Opinion Recommending EU Approval 2Hospira's Biosimilar Epoetin Retacrit(TM) Receives Positive Opinion Recommending EU Approval 3Massive reanalysis of genome data solves case of the lethal genes 2Sticky mussels inspire biomedical engineer yet again 2Sticky mussels inspire biomedical engineer yet again 3
... StabilCoat Immunoassay Stabilizer is an aqueous ... and other non-toxic chemicals in a PBS ... 7.4. This product does not contain ... the conformation and activity of dried protein ...
Mouse monoclonal antibody to PARK2 - Parkinson disease (autosomal recessive, juvenile) 2, parkin...
Rabbit polyclonal antibody to NMDA NR2B [Tyr1336]...
... tetrasodium bromide), 50mg/vial. MTT is a pale ... cells to yield a dark blue formazan ... even freshly dead cells do not cleave ... a component of Chemicons MTT assay kit, ...
Biology Products: