Navigation Links
Novel technique changes lymph node biopsy, reduces radiaiton exposure
Date:1/13/2009

Information obtained from a new application of photoacoustic tomography (PAT) is worth its weight in gold to breast cancer patients.

For the first time, Lihong Wang, Ph.D., Gene K. Beare Distinguished Professor in the Department of Biomedical Engineering, with a joint appointment in Radiology, and Younan Xia, Ph.D., James M. McKelvey Professor in Biomedical Engineering, with a joint appointment in chemistry in Arts & Sciences, both at Washington University in St. Louis, have used gold nanocages to map sentinel lymph nodes (SLN) in a rat noninvasively using PAT. Wang's lab is the largest PAT lab in the world credited with the invention of super-depth photoacoustic microscopy, and Xia's lab invented the gold nanocages.

Their work can minimize invasive surgical lymph node biopsy procedures to determine if breast cancer has metastasized and reduce the patient's exposure to radioactivity. The nanocages also have the potential to serve as an alternative to chemotherapy to kill targeted cancers by heating them up.

From heat, to expansion, to sound and an image

PAT blends optical and ultrasonic imaging to give high-resolution images of the body that contain information about physiology or tissue function. Molecules already present in the body (endogenous molecules, as opposed to exogenous ones that are from outside the body), such as melanin, hemoglobin, or lipids, can be used as endogenous contrast agents for imaging. When light is shone on the tissue, the contrast agent absorbs the light, converts it to heat, and expands. This expansion is detected as sound and decoded into an image.

"Using pure optical imaging, it is hard to look deep into tissues at high resolution because light scatters. The useful photons run out of juice within 1mm," Wang explained. "PAT improves tissue transparency by 2-3 orders of magnitude because sound scatters less than light. This allows us to see through the tissue by listening t
'/>"/>

Contact: Lihong Wang
lhwang@wustl.edu
31-493-593-56152
Washington University in St. Louis
Source:Eurekalert

Page: 1 2

Related biology news :

1. Salk researchers develop novel glioblastoma mouse model
2. Novel technique for fluorescence tomography of tumors in living animals
3. Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
4. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
5. A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart
6. A novel target for therapeutics against Staph infection
7. Corn researchers discover novel gene shut-off mechanisms
8. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
9. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
10. GEN reports on novel tools for deciphering biological networks
11. Novel publishing approach puts textbook in more hands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The Chinese University of Hong Kong, BGI and other ... to salt tolerance, with implication for improving this important ... online in Nature Communications provides an effective ... , Soybean is an important crop for the world. ... less genetic diversities than their wild counterparts. Among the ...
(Date:7/11/2014)... WASH. July 11, 2014 Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... to read a mouse,s mind, it takes some fluorescent protein ... Stanford scientists have demonstrated a technique for observing hundreds of ... real time, and have linked that activity to long-term information ... studying new therapies for neurodegenerative diseases such as Alzheimer,s. ...
... about to take up residence in the laboratories of Virginia ... to learn more about the water-running lizard,s ability to dart ... it increases its locomotion efficiency by producing more force on ... And these engineers are surprised at how some frog ...
... study led by an international team of biologists has identified some ... of their brain at a time. The study was published ... headed by scientists at UCLA and the University of Toronto. It ... half awake and asleep. Findings from this study may explain the ...
Cached Biology News:Stanford researchers develop tool for reading the minds of mice 2Nature's phenomena might teach Virginia Tech engineers new tricks 2Nature's phenomena might teach Virginia Tech engineers new tricks 3New study shows how seals sleep with only half their brain at a time 2
(Date:7/11/2014)... , July 11, 2014 /CNW/ - Sunovion Pharmaceuticals ... APTIOM TM (eslicarbazepine acetate) for use as a ... in patients with epilepsy who are not satisfactorily controlled ... for use in patients under 18 years of age. ... common neurological disorders and according to Epilepsy Canada, it ...
(Date:7/11/2014)... Cayenne Medical, Inc., a privately ... soft tissue reconstruction segment, announced the worldwide launch ... involving the shoulder and extremities. The SureLock System ... deployment method. The unique delivery eliminates manual tensioning ... or anchor displacement (also commonly know as anchor ...
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... 10, 2014 Understanding the need for ... lines, and the gap that currently exists in this ... its industry-leading portfolio of validated ion channel and GPCR ... cell lines, as ion channels control many critical physiological ... activity creates the potential to treat a variety of ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... Emmanuel Labourier , Ambion, Inc , ... from the same sample Enrich for , ... , for assessing siRNA or miRNA expression and ... (siRNAs) and , microRNAs (miRNAs) have emerged as ...
... , High ... Only ethically sourced tissue is used , Custom RNA isolations from tissue ... Begins at the Source , Use ... that you are getting the highest , quality ...
... In Vitro Translation Kit , ... of protein than reticulocyte , lysate systems , ... biological activity than other E. coli , lysate systems ... researchers studying protein function and , ...
Cached Biology Technology:Isolate It All: siRNA miRNA , Total RNA Native Protein 2Isolate It All: siRNA miRNA , Total RNA Native Protein 3Isolate It All: siRNA miRNA , Total RNA Native Protein 4Isolate It All: siRNA miRNA , Total RNA Native Protein 5Isolate It All: siRNA miRNA , Total RNA Native Protein 6Isolate It All: siRNA miRNA , Total RNA Native Protein 7Isolate It All: siRNA miRNA , Total RNA Native Protein 8Isolate It All: siRNA miRNA , Total RNA Native Protein 9High Quality RNA Isolation Services 2Increase Protein Activity and Yield 2Increase Protein Activity and Yield 3
... 20 System revolutionizes DNA sequencing, delivering sequence ... The Genome Sequencer 20 System includes: ... consumables for library construction, amplification, and sequencing ... novo assembly The instrument ...
... Proteolytic degradation is critical to the ... and regulatory proteins as important and ... metabolism, heat shock and stress response, ... receptors and ion channels, cell cycle ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential CV/Renal liabilities of compounds....
... demonstrated that oxidative stress is involved in ... stress is the condition in which an ... exist leading to the damage of a ... stress is through several antioxidant systems4 that ...
Biology Products: