Navigation Links
Novel storage mechanism allows command, control of memory
Date:3/5/2013

r in the study.

Using genetically-engineered mice, the researchers found that turning off mTORC2 in the hippocampus (a crucial region required for memory formation) and surrounding areas allowed the animals to have a normal short-term memory, but prevented them from forming long-term memories. Similar to human patients with injury in the hippocampus, these mutant mice were no longer able to form new long-lasting memories.

According to Costa-Mattioli's findings, mTORC2's role is evolutionarily conserved and likely relevant to humans. Like mTORC2-deficient mice, fruit flies lacking TORC2 show defective long-term memory storage.

"Given that flies and mice last shared a common ancestor 500 million years ago, it is quite remarkable and telling that the function of mTORC2 in the regulation of memory is indeed maintained," said Dr. Gregg Roman (http://www.bchs.uh.edu/people/faculty/research-divisions/index.php?155622-961-5=gwroman), director of the Biology of Behavior Institute at the University of Houston (http://www.uh.edu), who contributed to the fly experiments.

The Holy Grail of memory neuroscience and to a certain extent, of industry efforts to produce a "smart drug," has been the identification of molecules that promote the formation of long-term memory, said Costa-Mattioli. "We therefore wondered whether by turning on mTORC2 or even actin polymerization itself, we could form long-term memories more easily," said Dr. Ping Jun Zhu, assistant professor of neuroscience at BCM, co-first author and senior scientist in Costa-Mattioli's lab.

The team has identified a small molecule (a drug) that by activating mTORC2 and consequently actin polymerization enhances not only the synaptic strength between nerve cells but also long-term memory formation. In addition,
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces its biometric payment technology, ... featured in 2015 "I Want That" International CES Special, ... the DIY Network.   DIY,s "I Want ... site of the 2015 International CES for a firsthand ...
(Date:3/17/2015)... , March 17, 2015 Emotient, the ... software, today announced general availability of Emotient ... for the analysis of facial expressions. The system ... media content, products and services. It delivers audience ... and sentiment - as derived from facial evidence ...
(Date:3/12/2015)... BERLIN , March 12, 2015 ... IAM, a standardized identity and access management (IAM) ... reliable implementation schedule. With Beta System,s new IAM ... and best practices gleaned from multiple IAM implementations ... includes the software as well as any necessary ...
Breaking Biology News(10 mins):NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2
... A technique pioneered in the Tissue Engineering and Regenerative ... Zegarelli Professor of Dental Medicine at Columbia University Medical ... three-dimensional scaffold infused with growth factor, holding the translational ... soon as nine weeks once implanted. People who ...
... BIO-key International, Inc. (OTC Bulletin Board: BKYI), a leader in ... biometric software into its Enterprise Single Sign-on (SSO) solution. Additionally Evidian ... companies. , , , ... http://www.newscom.com/cgi-bin/prnh/20050509/BIOKEYLOGO ) , , ...
... some years back found ways to automate the production of ... life far easier. With complex carbohydrates, it,s been a different ... carbohydrate molecules for biological study has been slow and tedious. ... from the University of Georgia has created a method for ...
Cached Biology News:Technique yields potential biological substitute for dental implants 2BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 2BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 3BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 4New method for producing 'libraries' of important carbohydrate molecules 2New method for producing 'libraries' of important carbohydrate molecules 3
(Date:3/26/2015)... 2015 PAREXEL International Corporation (Nasdaq: ... research organization , announced today that the ... acquire all of the business assets of privately-owned ... of specialized pharmacovigilance services, based in Chandigarh, ... assessment, monitoring, and prevention of adverse effects ...
(Date:3/26/2015)... "In America," the popular news television program that airs in ... legendary film actor James Earl Jones, has announced that it ... , Botany is commonly described as the scientific study ... bit more complicated than that. Scientists and other professionals study ... the smallest bacteria known to man to the largest trees ...
(Date:3/26/2015)... 26, 2015 WriteResult, a premier provider ... from Yale University’s School of Public Health and New ... during a 4 month-long project. The goal of the ... income families with free access to fresh produce and ... health concerns like high blood pressure, diabetes and weight ...
(Date:3/25/2015)... 2015 Agnition announced today that it ... Farmer, airing for the first time at 7:30 a.m. ... Farmer will explore the extremely important role soil microbes ... a patented Microbial Catalyst™ technology that enhances soil and ... segment will air again on April 28. , A ...
Breaking Biology Technology:PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2
... brand from Dermaheal now available in the United States marries science ... biweekly home delivery. , ... Irvine, CA (PRWEB) December ... program, an organic, preservative-free product made fresh and delivered ...
... that food additives that contain nanoscale materials be subject ... does not pose unintended risks. , The call comes ... the incoming Obama administration. It also takes place amid ... Administration (FDA) and possibly create a separate government food ...
... Global Biopharmaceutical Company Purchases Two PCT Systems to Help in the ... , SOUTH EASTON, Mass., Dec. 17 Pressure ... they have entered into a collaboration with the J. Craig Venter ... in Rockville, MD and La Jolla, CA. As part of ...
Cached Biology Technology:Organic, Preservative-Free Skin Care Products from Dermaheal Now Available in the United States 2Organic, Preservative-Free Skin Care Products from Dermaheal Now Available in the United States 3Experts argue nano food-additives require new oversight 2Pressure BioSciences, Inc. and the J. Craig Venter Institute Announce Collaboration Agreement & Purchase of a PCT System 2Pressure BioSciences, Inc. and the J. Craig Venter Institute Announce Collaboration Agreement & Purchase of a PCT System 3Pressure BioSciences, Inc. and the J. Craig Venter Institute Announce Collaboration Agreement & Purchase of a PCT System 4Pressure BioSciences, Inc. and the J. Craig Venter Institute Announce Collaboration Agreement & Purchase of a PCT System 5
... vectors combine the proven features of the ... and provides all of the benefits and ... vector backbone. The pTriEx vectors have been ... genes in all three expression systems. In ...
... first instrument engineered to match the speed ... thousands of research centers worldwide. It uses ... are ideally suited for high-speed temperature cycling ... high surface-area-to-volume ratio. ,By combining glass capillary ...
... The MetaVue Imaging System is the ... With commands tailored to common research ... photography, morphometric analysis and simple image analysis. ... device control library means that MetaVue has ...
... Clear amber to slightly cloudy liquid. ... vials per set, each containing 10 ... in the following proportions by weight: ... (mannide monooleate emulsifier), and 0.1% ...
Biology Products: