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Novel protein essential for successful pregnancy
Date:5/28/2010

Researchers at Yale School of Medicine and their colleagues at the Society for the Investigation of Early Pregnancy have helped clarify the function of a unique protein called Preimplantation Factor, which is produced by healthy embryos to direct embryo attachment and help the mother adapt to pregnancy.

These findings are published fast track for the benefit of the scientific community in the current issue of American Journal of Obstetrics and Gynecology. They were first presented orally in February at the Society for Maternal Fetal Medicine Scientific Meetings in Chicago by lead author Michael J. Paidas, M.D., associate professor and co-director of the Yale Women and Children's Center for Blood Disorders.

The research showed that Preimplantation Factor modulates maternal immunity, promotes attachment of the early embryo, and influences remodeling of uterine cells.

"Preimplantation Factor appears to be essential for pregnancy to succeed," said Paidas. "For several decades, investigators have tried to isolate a compound that was absolutely required for pregnancy. We believe that Preimplantation Factor is in fact that compound."

Paidas and his colleagues conducted a genomic and proteomic study of both non-pregnant and pregnant uterine stromal cells, which are positioned directly beneath the uterine lining (epithelium). When these cells in culture were exposed to Preimplantation Factor, over 500 maternal genes and several proteins were significantly altered. Interestingly, Paidas said, profound changes were detected precisely in those pathways and networks critical for implantation.

Preimplantation Factor was discovered by co-author Eytan R. Barnea, M.D., founder of the Society for the Investigation of Early Pregnancy and clinical associate professor in the Department of Obstetrics, Gynecology & Reproduction, UMDNJ-Robert Wood Johnson Medical School. Barnea eventually synthesized Preimplantation Factor so
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Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

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