Navigation Links
Novel protein essential for successful pregnancy
Date:5/28/2010

Researchers at Yale School of Medicine and their colleagues at the Society for the Investigation of Early Pregnancy have helped clarify the function of a unique protein called Preimplantation Factor, which is produced by healthy embryos to direct embryo attachment and help the mother adapt to pregnancy.

These findings are published fast track for the benefit of the scientific community in the current issue of American Journal of Obstetrics and Gynecology. They were first presented orally in February at the Society for Maternal Fetal Medicine Scientific Meetings in Chicago by lead author Michael J. Paidas, M.D., associate professor and co-director of the Yale Women and Children's Center for Blood Disorders.

The research showed that Preimplantation Factor modulates maternal immunity, promotes attachment of the early embryo, and influences remodeling of uterine cells.

"Preimplantation Factor appears to be essential for pregnancy to succeed," said Paidas. "For several decades, investigators have tried to isolate a compound that was absolutely required for pregnancy. We believe that Preimplantation Factor is in fact that compound."

Paidas and his colleagues conducted a genomic and proteomic study of both non-pregnant and pregnant uterine stromal cells, which are positioned directly beneath the uterine lining (epithelium). When these cells in culture were exposed to Preimplantation Factor, over 500 maternal genes and several proteins were significantly altered. Interestingly, Paidas said, profound changes were detected precisely in those pathways and networks critical for implantation.

Preimplantation Factor was discovered by co-author Eytan R. Barnea, M.D., founder of the Society for the Investigation of Early Pregnancy and clinical associate professor in the Department of Obstetrics, Gynecology & Reproduction, UMDNJ-Robert Wood Johnson Medical School. Barnea eventually synthesized Preimplantation Factor so that the replicated form is identical to the native compound.

Studies are ongoing to establish Preimplantation Factor as a diagnostic test for pregnancy viability, not only in humans but in animals as well, since it appears to be universally present in mammals. Paidas said that there is even greater interest in the potential therapeutic applications, both in pregnancy and in other conditions such as autoimmune disease and transplantation. Preclinical studies are being conducted to pave the way for eventual human clinical trials.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related biology news :

1. MGH researchers describe new way to identify, evolve novel enzymes
2. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
3. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
6. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
7. Scientists discover novel way to remove iron from ferritin
8. Identification of a novel class of (not-so) small RNAs
9. A novel way found to prevent protein plaques implicated in Alzheimers
10. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... ... June 23, 2017 , ... The Academy ... and the University Aviation Association (UAA), the unifying voice for collegiate aviation education, ... will encourage teamwork, competition, and success through a STEM-based education platform. , Much ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... over the allergy specialists DST Diagnostische Systeme & Technologien GmbH, thereby expanding its ... someone who suffers from hay fever, urticaria, asthma, atopic eczema or a food ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... The first ... took 20 years until the first data on cross-contamination of human cell lines with ... been an increasing issue in cell culture labs and is associated with dramatic consequences ...
(Date:6/20/2017)... ... June 20, 2017 , ... Biologist Dawn Maslar MS has found a biomarker ... Men Chase, Women Choose: The Neuroscience of Meeting, Dating, Losing Your Mind, and Finding ... men. ”The logical next step, in my estimation, was to scientifically track the evidence ...
Breaking Biology Technology: