Navigation Links
Novel protein essential for successful pregnancy
Date:5/28/2010

Researchers at Yale School of Medicine and their colleagues at the Society for the Investigation of Early Pregnancy have helped clarify the function of a unique protein called Preimplantation Factor, which is produced by healthy embryos to direct embryo attachment and help the mother adapt to pregnancy.

These findings are published fast track for the benefit of the scientific community in the current issue of American Journal of Obstetrics and Gynecology. They were first presented orally in February at the Society for Maternal Fetal Medicine Scientific Meetings in Chicago by lead author Michael J. Paidas, M.D., associate professor and co-director of the Yale Women and Children's Center for Blood Disorders.

The research showed that Preimplantation Factor modulates maternal immunity, promotes attachment of the early embryo, and influences remodeling of uterine cells.

"Preimplantation Factor appears to be essential for pregnancy to succeed," said Paidas. "For several decades, investigators have tried to isolate a compound that was absolutely required for pregnancy. We believe that Preimplantation Factor is in fact that compound."

Paidas and his colleagues conducted a genomic and proteomic study of both non-pregnant and pregnant uterine stromal cells, which are positioned directly beneath the uterine lining (epithelium). When these cells in culture were exposed to Preimplantation Factor, over 500 maternal genes and several proteins were significantly altered. Interestingly, Paidas said, profound changes were detected precisely in those pathways and networks critical for implantation.

Preimplantation Factor was discovered by co-author Eytan R. Barnea, M.D., founder of the Society for the Investigation of Early Pregnancy and clinical associate professor in the Department of Obstetrics, Gynecology & Reproduction, UMDNJ-Robert Wood Johnson Medical School. Barnea eventually synthesized Preimplantation Factor so that the replicated form is identical to the native compound.

Studies are ongoing to establish Preimplantation Factor as a diagnostic test for pregnancy viability, not only in humans but in animals as well, since it appears to be universally present in mammals. Paidas said that there is even greater interest in the potential therapeutic applications, both in pregnancy and in other conditions such as autoimmune disease and transplantation. Preclinical studies are being conducted to pave the way for eventual human clinical trials.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related biology news :

1. MGH researchers describe new way to identify, evolve novel enzymes
2. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
3. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
6. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
7. Scientists discover novel way to remove iron from ferritin
8. Identification of a novel class of (not-so) small RNAs
9. A novel way found to prevent protein plaques implicated in Alzheimers
10. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/11/2017)... ... 11, 2017 , ... The CRISPR-Cas9 system has ... and avoiding the use of exogenous expression plasmids. The simplicity of programming this ... gain-of-function studies. , This complement to loss-of-function studies, such as with RNAi ...
(Date:10/11/2017)... Oct. 11, 2017  VMS BioMarketing, a leading provider of ... oncology Clinical Nurse Educator (CNE) network, which will launch this ... communication among health care professionals to enhance the patient care ... staff, and other health care professionals to help women who ... ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
Breaking Biology Technology: