Navigation Links
Novel pathway regulating angiogenesis may fight retinal disease, cancers
Date:5/29/2011

CINCINNATI Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers.

Researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide blood vessel patterning in the retina. Furthermore, in the same study researchers were able to reverse this pathway to accelerate the growth of branching vessels, which could be important to developing new methods for repairing damaged tissues.

"We show in the setting of retina that myeloid cells use this pathway to direct vascular traffic," explained Richard Lang Ph.D., senior investigator on the study and director of the Visual Systems Group in the Division of Ophthalmology at Cincinnati Children's Hospital Medical Center. "We think modulation of this pathway might become a promising therapeutic option.''

The study, to be published online May 29, demonstrates how retinal myeloid cells regulate blood vessel branching in the still-developing retinas of postnatal mice by using the Wnt protein signaling network. The Wnt pathway is known for its role in embryonic and early development as well as in cancer. Although myeloid cells play an important part in the immune system, these cells are also found in many different tumor types and promote tumor progression.

Through a series of experiments in cell cultures and mouse models, researchers determined the new pathway works by myeloid cells utilizing the Wnt pathway to regulate expression of a gene known as Flt1. Flt1 encodes a protein called vascular endothelial growth factor receptor-1 (VEGFR1), which suppresses vascular growth by binding vascular endothelial growth factor (VEGF). The expression of Flt1 can be adjusted so that when ramped up it inhibits VEGF and vascular branching, or when turned down it allows VE
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. GW researchers reveal 18 novel subtype-dependent genetic variants for autism spectrum disorders and identify potential genetic markers for diagnostic screening
2. Novel ash analysis validates volcano no-fly zones
3. Novel therapy improves immune function in teen with rare disease
4. Data suggest liver experts should take care when prescribing novel antiviral HCV drugs
5. Novel method could improve the performance of proteins used therapeutically
6. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
7. Team creates novel vaccine that produces strong immunity against cocaine high
8. Novel compounds show early promise in treatment of Parkinsons, Huntingtons, Alzheimers
9. GEN co-sponsors roundtable discussion on novel bioremediation techniques
10. In the lab, engineers novel liquid provides a solid fix for broken bones
11. Novel services for tropical forest monitoring with satellite
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... previously unknown process for harvesting energy and producing oxygen ... State University scientist has discovered. The discovery lays the ... harvesting energy from the Sun, and understanding dense blooms ... lakes worldwide. A paper describing the discovery will be ... the journal Science on 21 August 2014. ...
(Date:8/21/2014)... A ubiquitous skin fungus linked to dandruff, eczema and ... tracked to even further global reachesincluding Hawaiian coral reefs ... sea vents. , A review in the scientific journal ... distribution of the fungi of the genus Malassezia ... environmental sequencing datasets from around the world. , University ...
(Date:8/21/2014)... intake, health and quality of life of older adults ... the University of Waterloo receiving close to $1.5 million ... (CIHR). , Professor Heather Keller, of the Faculty ... research chair in nutrition and aging, will receive $979,000 ... in long-term care homes are poorly nourished. The project ...
Breaking Biology News(10 mins):Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Grants will fund landmark aging research at Waterloo 2
... will take place on the campus of the Abdus ... the Academy,s secretariat. TWAS,s new executive director, Romain Murenzi, ... of TWAS; Fernando Quevedo, director of ICTP; Immacolata Pannone, ... TWAS President, will highlight the opening ceremony. The morning ...
... 15, 2011   DigitalPersona, Inc. ... protection solutions, today announced at the CARTES & ... company has open sourced its new MINEX-certified FingerJetFX™ ... (OSE), is free, portable software that device manufacturers ...
... FRANCISCO, CANovember 15, 2011The American Heart Association will ... Emeritus Robert Mahley, MD, PhD, with the 2011 ... on one of Gladstone,s founding cardiovascular scientists. ... that the American Heart Association can give a ...
Cached Biology News:TWAS 22nd General Meeting in Trieste 2DigitalPersona Open Sources New FingerJetFX Biometrics Technology for Mobile Devices, PCs and Servers 2DigitalPersona Open Sources New FingerJetFX Biometrics Technology for Mobile Devices, PCs and Servers 3Gladstone founder receives American Heart Association Distinguished Scientist Award 2
(Date:8/22/2014)... are intensively investigated for application as catalysts, ... and components in photonics and molecular electronics. ... for understanding physical and chemical properties, has ... USA, have demonstrated that high-resolution electron microscopy ... structure in which all gold atoms are ...
(Date:8/22/2014)... The AMA is pleased to share with the ... Alaska Governor Sean Parnell has signed House Bill 255 ... of Unmanned Aircraft Systems and the continuation of the ... it is, “An Act relating to unmanned aircraft systems; ... system.” It defines State of Alaska laws regarding data ...
(Date:8/21/2014)... 21, 2014 DNA vaccine pioneer ... its development of JRC-LAMP-vax, an innovative and safe potential ... IC studies began this month in Hawaii, moving the ... , The Japanese red cedar releases pollen that causes ... Mountain Cedar pollen wreaks similar havoc in Colorado, New ...
(Date:8/21/2014)... 2014 His Majesty Willem-Alexander, King of ... Court of His Majesty Willem-Alexander, King of the Netherlands, ... Opening of POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol ... The King will take part in the Grand Opening ... 11 a.m.-12:20 p.m. and tour the plant. POET-DSM is ...
Breaking Biology Technology:A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... communications system. Image courtesy of GE Healthcare. Wisconsin ... include $10 million for a grant and loan program ... systems. , ,"I am committed to ensuring that all ... why I am pleased to unveil a proposal of ...
... and Minnesota students will get a one-of-a-kind experience today ... the International Space Station Expedition 10 crew. , ,The ... EST today at Crossroads Elementary School, St. Paul, Minn. ... Leroy Chiao and Flight Engineer Salizhan Sharipov. Nearly 700 ...
... human embryos. , ,This weeks announcement out of Kings ... the sheep, has been granted a license by the British ... hopes among disease sufferers, scientists and advocacy groups for a ... (ALS). , ,These diseases could be addressed through research on ...
Cached Biology Technology:Doyle proposes $10M to expand use of electronic medical records 2Doyle proposes $10M to expand use of electronic medical records 3Human cloning plans get blessing from British government 2Human cloning plans get blessing from British government 3
Hybridization cassette for one slide...
Request Info...
Contains 0.2 g/L EDTA4Na in phosphate-buffered saline....
Quantibody Human Angiogenesis Array 1 (1 slide) Class: Quantitative Antibody Arrays Product Group: Antibody Array...
Biology Products: