Navigation Links
Novel pathway regulating angiogenesis may fight retinal disease, cancers
Date:5/29/2011

CINCINNATI Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers.

Researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide blood vessel patterning in the retina. Furthermore, in the same study researchers were able to reverse this pathway to accelerate the growth of branching vessels, which could be important to developing new methods for repairing damaged tissues.

"We show in the setting of retina that myeloid cells use this pathway to direct vascular traffic," explained Richard Lang Ph.D., senior investigator on the study and director of the Visual Systems Group in the Division of Ophthalmology at Cincinnati Children's Hospital Medical Center. "We think modulation of this pathway might become a promising therapeutic option.''

The study, to be published online May 29, demonstrates how retinal myeloid cells regulate blood vessel branching in the still-developing retinas of postnatal mice by using the Wnt protein signaling network. The Wnt pathway is known for its role in embryonic and early development as well as in cancer. Although myeloid cells play an important part in the immune system, these cells are also found in many different tumor types and promote tumor progression.

Through a series of experiments in cell cultures and mouse models, researchers determined the new pathway works by myeloid cells utilizing the Wnt pathway to regulate expression of a gene known as Flt1. Flt1 encodes a protein called vascular endothelial growth factor receptor-1 (VEGFR1), which suppresses vascular growth by binding vascular endothelial growth factor (VEGF). The expression of Flt1 can be adjusted so that when ramped up it inhibits VEGF and vascular branching, or when turned down it allows VE
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. GW researchers reveal 18 novel subtype-dependent genetic variants for autism spectrum disorders and identify potential genetic markers for diagnostic screening
2. Novel ash analysis validates volcano no-fly zones
3. Novel therapy improves immune function in teen with rare disease
4. Data suggest liver experts should take care when prescribing novel antiviral HCV drugs
5. Novel method could improve the performance of proteins used therapeutically
6. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
7. Team creates novel vaccine that produces strong immunity against cocaine high
8. Novel compounds show early promise in treatment of Parkinsons, Huntingtons, Alzheimers
9. GEN co-sponsors roundtable discussion on novel bioremediation techniques
10. In the lab, engineers novel liquid provides a solid fix for broken bones
11. Novel services for tropical forest monitoring with satellite
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... No matter how many times it,s demonstrated, ... communicating creatures. , But by using a ... radically alter their behavior to suit their population. ... them are present, and act accordingly. , Once ... it may change from innocuous to pathogenic, or ...
(Date:9/18/2014)... information is stored in DNA, tiny strands of nucleic ... bodies. To express this genetic data, our DNA is ... into proteins that perform tasks in our cells. ... of RNA molecule. Unlike all other known RNAs, this ... circRNA molecules are abundant, little has been known about ...
(Date:9/18/2014)... and ethnic groups describe losing eyesight as potentially ... more so than other conditions including: loss of ... 49% of non-Hispanic whites, 43% of Asians and ... ailment is the worst that could happen to ... AIDS/HIV. Hispanics and Asians ranked cancer first ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3
... in French . Quebec City, December ... Agricultural College, have discovered what causes Christmas tree needles to ... trees in homes. The authors presented their findings in a ... The researchers have identified a plant hormoneethyleneresponsible for needle loss ...
... Bioengineers from the University of California, San Diego developed ... sooner than others in the brains of people with ... Nature Biotechnology on November 21, come from detailed ... of Bioengineering at the UC San Diego Jacobs School ...
... that sink down to the seafloor provide a feast ... research suggested that such "whale falls" were homes for ... five whale carcasses in Monterey Canyon, researchers from the ... of the animals at these sites were not unique ...
Cached Biology News:Researchers discover a way to delay Christmas tree needle loss 2Metabolism models may explain why Alzheimer's disease kills some neuron types first 2Metabolism models may explain why Alzheimer's disease kills some neuron types first 3Fleshing out the life histories of dead whales 2Fleshing out the life histories of dead whales 3Fleshing out the life histories of dead whales 4
(Date:9/18/2014)... A novel robotic system that can operate ... being tested as part of a biomedical research partnership ... the aim of determining if the robot, in conjunction ... faster, more accurate, less costly, and less discomforting for ... to deliver prostate cancer therapies with greater precision. , ...
(Date:9/18/2014)... Texas (PRWEB) September 18, 2014 ... Chancellor John Sharp, Texas A&M Health Science Center ... U.S. Department of Health and Human Services (HHS), ... dedicated a national pandemic influenza vaccine manufacturing facility ... as an anchor for the Texas A&M Biocorridor ...
(Date:9/18/2014)... Sept. 18, 2014 Research and ... "Global N-acetylcysteine Industry Report 2014" report ... N-acetylcysteine Industry Report 2014 is a professional and ... global N-acetylcysteine industry. The report provides ... classifications, applications and industry chain structure. The N-acetylcysteine ...
(Date:9/18/2014)... September 18, 2014 Leatherwood Plastics ... listed material, to stay competitive in the semiconductor, ... high-performance materials ultimately impact product quality and productivity, ... owner. , Established in 1980 in Lewisville, TX, ... many fabricators have left the business. Much of ...
Breaking Biology Technology:Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global N-acetylcysteine Industry Report 2014 2Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2
... , ... teaming-up with beer pioneer Karl Strauss Brewing Company to convert spent beer yeast into ... ... GreenHouse is teaming-up with beer pioneer Karl Strauss Brewing Company to convert spent beer ...
... - Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI , ... Scientific Corporation (NYSE: BSX ) has received ... to market its TAXUS(R) Liberte(R) Long Paclitaxel-Eluting Coronary Stent ... lesions. At 38 mm, it is the longest available ...
... 16 Dow AgroSciences LLC, a wholly owned subsidiary of The ... Perth based biotechnology company, announced today a newly established collaboration agreement ... , The collaboration will support a number ... the agreement were not disclosed. , , ...
Cached Biology Technology:Karl Strauss and GreenHouse Partner to Create Alternative Fuel from Beer Waste 2Karl Strauss and GreenHouse Partner to Create Alternative Fuel from Beer Waste 3Angiotech Pharmaceuticals announces FDA approval of TAXUS(R) Liberte(R) Long Stent 2Angiotech Pharmaceuticals announces FDA approval of TAXUS(R) Liberte(R) Long Stent 3Angiotech Pharmaceuticals announces FDA approval of TAXUS(R) Liberte(R) Long Stent 4Angiotech Pharmaceuticals announces FDA approval of TAXUS(R) Liberte(R) Long Stent 5Dow AgroSciences, NemGenix Establish New Collaboration in Plant Biotechnology 2