Navigation Links
Novel pathway regulating angiogenesis may fight retinal disease, cancers
Date:5/29/2011

CINCINNATI Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers.

Researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide blood vessel patterning in the retina. Furthermore, in the same study researchers were able to reverse this pathway to accelerate the growth of branching vessels, which could be important to developing new methods for repairing damaged tissues.

"We show in the setting of retina that myeloid cells use this pathway to direct vascular traffic," explained Richard Lang Ph.D., senior investigator on the study and director of the Visual Systems Group in the Division of Ophthalmology at Cincinnati Children's Hospital Medical Center. "We think modulation of this pathway might become a promising therapeutic option.''

The study, to be published online May 29, demonstrates how retinal myeloid cells regulate blood vessel branching in the still-developing retinas of postnatal mice by using the Wnt protein signaling network. The Wnt pathway is known for its role in embryonic and early development as well as in cancer. Although myeloid cells play an important part in the immune system, these cells are also found in many different tumor types and promote tumor progression.

Through a series of experiments in cell cultures and mouse models, researchers determined the new pathway works by myeloid cells utilizing the Wnt pathway to regulate expression of a gene known as Flt1. Flt1 encodes a protein called vascular endothelial growth factor receptor-1 (VEGFR1), which suppresses vascular growth by binding vascular endothelial growth factor (VEGF). The expression of Flt1 can be adjusted so that when ramped up it inhibits VEGF and vascular branching, or when turned down it allows VEGF to increase branching.

Dr. Lang said the Wnt-Flt1 response is a new pathway for regulating VEGF-stimulated angiogenesis (blood vessel formation). This presents a number of new research opportunities to test its influence on retinal diseases that are often associated with abnormal blood vessel development and in tumor formation, he added.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Related biology news :

1. GW researchers reveal 18 novel subtype-dependent genetic variants for autism spectrum disorders and identify potential genetic markers for diagnostic screening
2. Novel ash analysis validates volcano no-fly zones
3. Novel therapy improves immune function in teen with rare disease
4. Data suggest liver experts should take care when prescribing novel antiviral HCV drugs
5. Novel method could improve the performance of proteins used therapeutically
6. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
7. Team creates novel vaccine that produces strong immunity against cocaine high
8. Novel compounds show early promise in treatment of Parkinsons, Huntingtons, Alzheimers
9. GEN co-sponsors roundtable discussion on novel bioremediation techniques
10. In the lab, engineers novel liquid provides a solid fix for broken bones
11. Novel services for tropical forest monitoring with satellite
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
Breaking Biology News(10 mins):
(Date:4/28/2017)... ... April 28, 2017 , ... KCAS Bioanalytical ... a 0.2 ng/mL lower limit (LLOQ) assay for nicotine and two key metabolites ... the ultra-low trace nicotine assay meets additional needs of tobacco industry that need ...
(Date:4/27/2017)... ... April 27, 2017 , ... This month ... consent (eConsent) solution that simplifies research studies, accelerates study startup, and improves participant ... Q Consent™ is the first and only IRB-integrated eConsent solution . , ...
(Date:4/27/2017)... ... April 27, 2017 , ... Volunteers ... other scientists, researchers, engineers, and industry professionals in visiting U.S. Congressional offices in ... compete in the world photonics industry. , This year, National Photonics Initiative ...
(Date:4/26/2017)... SC (PRWEB) , ... April 26, 2017 , ... ... mind, has teamed up with NASA to showcase the future of deep space ... Launch System (SLS) rocket and Orion spacecraft and includes a guest appearance by ...
Breaking Biology Technology: