Navigation Links
Novel noninvasive therapy prevents breast cancer formation in mice
Date:1/1/2014

HoxA1 that had the strongest statistical link to cancer.

The researchers wanted to know if blocking the HoxA1 gene could reverse cancer in lab-grown cells from mouse milk ducts. Amy Brock, Ph.D., a former Wyss Institute postdoctoral fellow who is now an Assistant Professor of Biomedical Engineering at the University of Texas, Austin, grew healthy mouse or human mammary-gland cells in a nutrient-rich, tissue-friendly gel. Healthy cells ensconced in the gel formed hollow spheres of cells akin to a normal milk duct. But cancerous cells, in contrast, packed together into solid, tumor-like spheres.

Brock treated cancerous cells with a short piece of RNA called a small interfering RNA (siRNA) that blocks only the HoxA1 gene. The cells reversed their march to malignancy, stopping their runaway growth and forming hollow balls as healthy cells do. What's more, they specialized as if they were growing in healthy tissue.

The siRNA treatment also stopped breast cancer in a line of mice genetically engineered to have a gene that causes all of them to develop cancer. The Wyss team worked with Michael Goldberg, Ph.D., Assistant Professor of Microbiology and Immunobiology at Harvard Medical School and the Dana-Farber Cancer Institute, to leverage a novel method he had developed to deliver the siRNA efficiently.

They packed the siRNA into nanoparticles called lipidoids that allow for genes to be silenced for weeks inside the body. They then did something unusual: they injected these nanoparticles directly through the nipples into the milk ducts of the cancer-prone mice, using a new method that Silva Krause, Ph.D., a postdoctoral fellow on Ingber's team, had developed. This is important because the cells that line the ducts are the ones that form breast tumors in mice as well as humans.

Weeks went by as Brock and Krause watched. The treated mice remained healthy, while untreated mice developed breast cancer. "There was no aha moment,"
'/>"/>

Contact: Dan Ferber
dan.ferber@wyss.harvard.edu
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel noninvasive therapy prevents breast cancer formation in mice
(Date:12/10/2014)... 9, 2014 CIE San Diego has launched ... the connective tissue that enhances care coordination among social ... share client-level information; earned a second $1 million grant ... serving seniors aging in community and; will be recognized ... 11 th 4-6p. CIE San Diego ...
(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:12/3/2014)... 2, 2014   Marvin Test Solutions , ... solutions for military, aerospace, and manufacturing organizations, today ... successful TS-900 PXI semiconductor test platform . ... high-end systems to customers at a fraction of ... traditional ATE. "Our semiconductor customers ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... de Physiologie Neurovg tative (CNRS-INRA-Universit Paul C zanne), the ... and from the D partement Lipoprotines et M ... Professor Jean-Pierre Miolan, Dr Jean-Pierre Niel, Directeur de Recherche ... Dr Abel Hiol Ma tre de confrence and ...
... international research team, including biologists from NOAA Fisheries Service, ... had failed to find a single Yangtze River dolphin, ... scientists fear the marine mammal is now extinct due ... the first cetacean to vanish as result of human ...
... Springer, one of the worlds leading STM publishers, will ... publication of the EUCC the Coastal Union. ... to Springers other journals in coastal science, the International ... The first issue of the relaunched JCCO, with ...
Cached Biology News:Scientists fear rare dolphin driven to extinction by human activities 2Springer will publish Journal of Coastal Conservation 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... TAI,AN, Shandong, China, Sept. ... Bulletin Board: CBPO) ("China Biologic," or the,"Company"), ... in the,People,s Republic of China ("PRC"), operating ... Products Co. Ltd.,("Taibang") and Chongqing Dalin Biologic ...
... CORK, Ireland, September 10 Hovione announced today that,Terry Lambe, ... Ltd. , Hovione acquired earlier this year ... element of the Hovione strategy to become a,leading manufacturer to the ... welcome Terry Lambe to Hovione. We want to build our,Cork site ...
... ROTTERDAM, The Netherlands, September 10 arGEN-X ... human,antibodies using its proprietary SIMPLE Antibody(TM) platform, today,announced the successful ... raised EUR 9.5million ( USD 13.6 million) from a,syndicate of ... largest of its kind in the last 12 months. , ...
Cached Biology Technology:China Biologic Products to Attend at Susquehanna's Third Annual Beijing Management Summit 2China Biologic Products to Attend at Susquehanna's Third Annual Beijing Management Summit 3Hovione Appoints Terry Lambe to its Board of Directors 2arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 2arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 3arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 4arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 5
muscle actin (HUC1-1)...
Anti-Mouse MIP-1g, Biotin (Polyclonal) (rabbit IgG)...
... Anti-NY-ESO-1, clone E978 ... NM_001327 Immunogen : ... Formulation: mouse ascites with ... Assurance: routinely evaluated by ...
... Opsin 1 ( Abpromise for all tested ... YEDSTHASIFTYT, corresponding to amino acids 14/26 of Mouse ... to amino acids 18/30 of tiger red cones ... Entrez Gene ID: 5956 ...
Biology Products: