Navigation Links
Novel method could improve the performance of proteins used therapeutically
Date:3/9/2011

en), interleukin (IL) 2 (known as aldesleukin and marketed as Proleukin), IL-4, IL-7, IL9-, and IL-15.

"In the course of this work, the first author of the PNAS paper, Maximilian Popp, together with other members of the lab, has put together a nice palette of sortase-based techniques that now allow us to modify a large variety of different proteins, and equip them with properties and behaviors that cannot be easily specified by more standard molecular biological techniques," says Whitehead Member Hidde Ploegh. "I see the value of these approaches first and foremost in their general applicability and ease of use."

IFN-alpha 2 is a cytokine, a hormone-like substance that usually acts on cells other than those that produce the protein. Upon binding the cytokine, the recipient cell responds, for example by starting to divide and proliferate, or by exercising certain functions of benefit to the organism. Like other cytokines used for therapeutic purposes, IFN-alpha 2 can be a finicky drug. It is thermally unstable and must be continuously refrigerated to maintain its potency, a requirement that limits IFN-alpha 2's use in areas with intermittent or no electricity. Also, IFN-alpha 2's relatively short half-life (and resulting rapid clearance from the body) often necessitates frequent injections when the drug is used to treat certain conditions.

To keep therapeutic IFN-alpha 2 active in the body longer, the current strategy is to tack long polyethylene glycol (PEG) chains onto the protein to turn them into effective drugs. This so-called PEGylation not only masks IFN-alpha 2 from the patient's immune system but also increases the time the body needs to break it down. However, because current approaches to PEGylation are not specific, the PEG chains can block or alter the protein's normal binding sitean unintended consequence of this modification that can diminish IFN-alpha 2's potency by as much as 90%.

Seeking greater precisio
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
2. Team creates novel vaccine that produces strong immunity against cocaine high
3. Novel compounds show early promise in treatment of Parkinsons, Huntingtons, Alzheimers
4. GEN co-sponsors roundtable discussion on novel bioremediation techniques
5. In the lab, engineers novel liquid provides a solid fix for broken bones
6. Novel services for tropical forest monitoring with satellite
7. In new novel, secret discovery threatens company and damages love affair
8. Dow Agrosciences licenses exclusive novel crop enhancement technology
9. Novel regulatory process for T cells may help explain immune system diseases
10. Novel protein critical for cellular proliferation discovered
11. Novel reference material to standardize gene therapy applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... be cultivated efficiently, they are anything but sustainable: ... monoculture cultivation is becoming increasingly evident. Despite their ... and are regarded as the sole possibility of ... wrongfully, finds Bernhard Schmid, an ecology professor at ... form of agriculture and forestry. After all, a ...
(Date:10/15/2014)... PORT WASHINGTON, N.Y. , Oct. 15, 2014 ... in technology solutions for home and community-based care, ... the benefits of implementing Sandata,s Santrax® Electronic Visit ... Quality Care Services is a home health company ... Texas . ...
(Date:10/15/2014)... spreading rapidly and to an unexpected extent. The outbreak ... and the virus shows a new disease dynamic in ... this reason, the German National Academy of Sciences Leopoldina, ... and the Union of the German Academies of Sciences ... epidemic today. , In the statement the academies call ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... 2012 Aware, Inc. (NASDAQ: AWRE ), a leading ... financial results for its first quarter ended March 31, 2012.  ... million, a decrease of 10% compared to $6.4 million in the ... 2012 was $1.1 million, or $0.05 per diluted share. These results ...
... Huntington disease (HD) is an inherited neurodegenerative disorder ... the Huntingtin gene, a CAG repeat occurs too many ... or 50s, but studies have shown that significant brain ... diagnosis. As a result, the field has sought a ...
... of Plant Biologists (ASPB) is pleased to announce the recipients ... and service. Charles Reid Barnes Life Membership ... University of Florida, Gainesville , Established in 1925, the ... honoring lifelong service in plant biology. Hanson, this year,s honoree, ...
Cached Biology News:Aware, Inc. Reports First Quarter 2012 Financial Results 2Aware, Inc. Reports First Quarter 2012 Financial Results 3Aware, Inc. Reports First Quarter 2012 Financial Results 4Aware, Inc. Reports First Quarter 2012 Financial Results 5Striatal brain volume predicts Huntington disease onset 2ASPB names 2012 award recipients 2ASPB names 2012 award recipients 3ASPB names 2012 award recipients 4ASPB names 2012 award recipients 5
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
(Date:10/20/2014)... Richardson, Texas (PRWEB) October 20, 2014 ... today announced that a team from Iowa State University ... * design contest. Using a Convey HC-2ex, the team’s ... than 14 times faster than the second place finisher. ... academic world embarked upon the month long challenge, using ...
(Date:10/20/2014)... , A major pan-European survey ... delivery of care has revealed changing trends in many ... the provision of healthcare services across the continent. The ... European Gastroenterology (UEG), have been announced today and led ... the burden of GI disorders across Europe ...
(Date:10/20/2014)... October 20, 2014 OncLive® ... Kimmel Cancer Center at Thomas Jefferson University has ... Through the Strategic Alliance Partnership program, the Sidney ... collaborate to raise awareness of the Center’s cutting-edge ... other projects. Clinicians and other health care professionals ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... to $33.2 Million, ... $12.8 Million, -- The Company Provides ... NEW YORK and HAIKOU, Hainan, China, March 31,/Xinhua-PRNewswire-FirstCall/ -- ... which develops, manufactures, and,markets generic and branded bio-pharmaceutical products ...
... on Lead Compounds That Directly and Specifically Activate ... ... Massachusetts, March 31 Mercury Therapeutics,Inc. (MTI), a company that discovers ... filed for patent protection on,three lead compounds that directly and specifically ...
... Vaccine Technology and ... Bird Flu Clinical Program, Webcast/teleconference Call Set ... March 31 Carrington,Laboratories, Inc. (OTC Bulletin Board: CARN) today reported ... ($0.90) per basic and,diluted share, for the year ended December 31, ...
Cached Biology Technology:China Pharma Holdings, Inc. Announces Record 2007 Year End Results 2China Pharma Holdings, Inc. Announces Record 2007 Year End Results 3China Pharma Holdings, Inc. Announces Record 2007 Year End Results 4China Pharma Holdings, Inc. Announces Record 2007 Year End Results 5China Pharma Holdings, Inc. Announces Record 2007 Year End Results 6China Pharma Holdings, Inc. Announces Record 2007 Year End Results 7China Pharma Holdings, Inc. Announces Record 2007 Year End Results 8China Pharma Holdings, Inc. Announces Record 2007 Year End Results 9China Pharma Holdings, Inc. Announces Record 2007 Year End Results 10China Pharma Holdings, Inc. Announces Record 2007 Year End Results 11Mercury Therapeutics Patents Filed 2Mercury Therapeutics Patents Filed 3Carrington Reports 2007 Financial Results 2Carrington Reports 2007 Financial Results 3Carrington Reports 2007 Financial Results 4Carrington Reports 2007 Financial Results 5Carrington Reports 2007 Financial Results 6Carrington Reports 2007 Financial Results 7
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
Immunogen: Tissue / cell preparation. (Murine EHS laminin preparation) Storage: -20 C, Avoid Freeze/Thaw Cycles...
p-Raf-1 (Ser 338/Tyr 341)-R...
Rabbit polyclonal to Syntrophin alpha 1 ( Abpromise for all tested applications). entrezGeneID: 6640 SwissProtID: Q13424...
Biology Products: