Navigation Links
Novel mechanism for long-term learning identified by Carnegie Mellon researchers
Date:1/3/2008

PITTSBURGH Practice makes perfect or at least thats what were told as we struggle through endless rounds of multiplication tables, goal kicks and piano scales and it seems, based on the personal experience of many, to be true. Thats why neuroscientists have been perplexed by data showing that at the level of individual synapses, or connections between neurons, increased, repetitive stimulation might actually reverse early gains in synaptic strength. Now, neuroscientists from Carnegie Mellon University and the Max Planck Institute have discovered the mechanism that resolves this apparent paradox. The findings are published in the Jan. 4 issue of Science.

The mechanism further explains how brain synapses strengthen in response to new experiences. Previous research by Carnegie Mellon researcher and lead author of the study Alison Barth has shown that there is a connection between synaptic plasticity, or changes, and learning and memory. However, little was known about the mechanisms that underlie learning that occurs over longer timeframes, with continuing training or practice.

Scientists have shown that N-methyl-D-aspartate (NMDA) receptors are required to initiate synaptic plasticity in this mechanism, a fact that holds true in many areas of the brain. Indeed, it is becoming increasingly clear that these receptors are required for the kind of synaptic strengthening that occurs during learning.

Barth and colleagues discovered that the NMDA receptors undergo a sort of Jekyll-and-Hyde transition after an initial phase of learning. Instead of helping synapses get stronger, they actually begin to weaken the synapses and impair further learning. According to Barth, scientists knew that logically, after an initial learning or training experience, this change in receptor function and resulting synapse deterioration would mean that learning would stop, and perhaps with continued stimulation neural processes might even degrade but experience sh
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MGH researchers describe new way to identify, evolve novel enzymes
2. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
3. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
6. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
7. Scientists discover novel way to remove iron from ferritin
8. Identification of a novel class of (not-so) small RNAs
9. A novel way found to prevent protein plaques implicated in Alzheimers
10. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/23/2015)... Conn. , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces its ... new advertising campaign on CNBC television starting March 30 th ... will commence airing in New York ... Officer said: "We are excited about our new ad campaign ...
(Date:3/20/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces its ... of the products featured in 2015 "I Want That" ... PM EST on the DIY Network.   ... Vegas , site of the 2015 International CES ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... (Dec. 19, 2008) With the growing availability ... many scientists are now focusing on factors that govern ... biology known as transcriptional regulation. A new edition ... just been published by Cold Spring Harbor Laboratory Press. ...
... results of the first computer model that simulates ... individual clouds have been analyzed by a team ... (IPRC) at the University of Hawai`i at Mānoa, ... and the University of Tokyo. The model, ...
... grants of up to $200,000 annually for two ... for transportation. Each project must have researchers from ... eventually attract external funding and ultimately be good ... a world-class research and development organization like Fraunhofer ...
Cached Biology News:New edition of laboratory manual includes cutting-edge techniques to study gene regulation 2
(Date:5/1/2015)... 2015 A new report by  ... will reach $22.4bn in 2019. That revenue forecast and ... Market Prospects 2015-2025 ,  published in March ... to provide forecasts and qualitative analyses of the antithrombotic ... consultancy in London, UK . It ...
(Date:5/1/2015)... May 1, 2015 Albany Molecular Research Inc. ... S. Marth , AMRI,s President and Chief Executive Officer, ... 2015 Health Care Conference on Wednesday, May 13, 2015 ... webcast of the presentation can be accessed at AMRI,s ... The webcast will be archived for 90 days ...
(Date:5/1/2015)... and RESEARCH TRIANGLE PARK, N.C. , ... ) announced today that Roger Jeffs , Ph.D., President ... overview and update on the company,s business at the Deutsche ... Boston, Massachusetts . The presentation will ... Eastern Time, and can be accessed via a live webcast ...
(Date:4/30/2015)... WARREN, N.J. , April 30, 2015  Roka ... company focused on providing advanced testing solutions for the ... financial results for the first quarter of 2015 on ... markets. Roka Bioscience will also host a ... 7, 2015 to discuss its first quarter financial results. ...
Breaking Biology Technology:Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2
... JOSE, Calif., March 12 Oncolys BioPharma,Inc. (Tokyo, ... USA),announced today that they have entered into a ... throughout Asia, Tacere,s,RNA interference (RNAi)-based Hepatitis C virus ... agreement resulted from the,strategic alliance entered into by ...
... HAS CLINCIAL, CORPORATE AND REGULATORY EXPERIENCE IN STEM ... ... Corp. (Nasdaq: KOOL ), a leading supplier of innovative,products that ... Vice President, Stem Cells and Regenerative Medicine at,Invitrogen Corporation, has been ...
... 12 f-star, an antibody,engineering company developing novel ... Antibody Technology, announced today that it,will open a ... its,headquarters in Vienna, Austria. The facility will be ... number of biotech companies and close,to the Medical ...
Cached Biology Technology:Oncolys BioPharma and Tacere Therapeutics Sign Strategic Alliance and License Agreement to Develop and Commercialize RNAi Hepatitis C Drug 2Oncolys BioPharma and Tacere Therapeutics Sign Strategic Alliance and License Agreement to Develop and Commercialize RNAi Hepatitis C Drug 3ThermoGenesis Names Dr. Mahendra Rao to Board of Directors 2ThermoGenesis Names Dr. Mahendra Rao to Board of Directors 3ThermoGenesis Names Dr. Mahendra Rao to Board of Directors 4Antibody Engineering Company f-Star Opens Second Research Site in Cambridge, UK 2
... The wide and long ... of Polaroid gel documentation systems. ... holds the camera in place ... that allows photography on the ...
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
... Zyagen tissue microarrays are derived from frozen ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... coated slides. Sections are large (3-5mm in ...
... for Optimal Microdissection , CapSure HS and ... and rapid extraction of populations of pure ... with Laser Capture Microdissection., Ensure the ... Analysis , All CapSure LCM Caps have ...
Biology Products: