Navigation Links
Novel mechanism discovered in first line of immune defense
Date:9/10/2013

1. Scientists from A*STAR's Singapore Immunology Network (SIgN) have discovered a new defense mechanism that the immune system utilises to combat infections. The team's discovery of how a novel protein unexpectedly activates an immune response shows how this mechanism can also be used to get rid of tumour cells. This research was done in collaboration with University Hospital Basel, Switzerland, published in July 2013 in Nature Immunology.

2. The immune system combats microbes using several strategies, of which early activation of defence is one of the most important. The mechanisms used by the immune system to counterattack microbes often rely on the immediate recognition of microbes, or of cells that have been affected by the infection of microbes.

3. The team at SIgN led by Prof Gennaro De Libero has identified a novel mechanism of how the immune system readily detects invading microbes and effectively initiates early immune responses, by activating a special class of cells called gamma delta lymphocytes. Gamma delta lymphocytes were discovered more than 30 years ago and had been identified as cells that are capable of early protection as they play a decisive role in the first line of immune defence. However, many studies into discovering the mechanisms of how these cells are activated when microbes attack have been unfruitful.

4. The team's discovery of a protein called Butyrophilin 3A1 shows how it binds to microbial antigens and hence activates human gamma delta cells. These cells are then able to coordinate an immune response to clear the infection caused by invading microbes.

5. This protein has also been found to bind antigens that are produced in large amounts in tumour cells, which then activates gamma delta cells against these tumour cells. The discovery of this mechanism thus represents a novel target that will help to eradicate tumours and combat infections.

6. Prof De Libero said, "The identification of the molecular m
'/>"/>

Contact: Vithya Selvam
vithya_selvam@a-star.edu.sg
656-826-6291
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces its biometric payment technology, ... featured in 2015 "I Want That" International CES Special, ... the DIY Network.   DIY,s "I Want ... site of the 2015 International CES for a firsthand ...
(Date:3/19/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces its biometric payment technology, the ... aired this week on Washington DC,s ... a segment "The Next Great Thing", host Laura Evans ... pay, and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... to any process by which a cell converts one ... of signal transduction involve ordered sequences of biochemical reactions ... and activated by second messengers, resulting in a signal ... the order of milliseconds in the case of ion ...
... found the dose of DHA (docosahexaenoic acid) that is "just ... research report appearing in the September 2009 print issue of ... show that a 200 mg dose of DHA per day ... problems, such as those related to aging, atherosclerosis, and diabetes. ...
... Travelers to the neotropicsthe tropical lands of the Americasmight ... insects flittering over sunny puddles or among dense forest ... are moths that have reinvented themselves as butterflies, converging ... hairy relatives. Now, a new revision of the taxonomic ...
Cached Biology News:Moths cloaked in color 2Moths cloaked in color 3Moths cloaked in color 4
(Date:4/1/2015)... DUBLIN , Mar. 30, 2015 Research ... announced the addition of the "Blood Screening ... Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western ... Bank, Hospital) - Forecasts to 2019 " ... screening market is expected to reach $2.55 billion ...
(Date:4/1/2015)... 30, 2015 Research and Markets ... the "Forensic Technologies and Services - Global ... This report analyzes the US market ... by the following Segments: Forensic Databases, Forensic Consulting ... Annual estimates and forecasts are provided ...
(Date:4/1/2015)... 1, 2015  Spherix Incorporated (Nasdaq: SPEX ... fostering and monetization of intellectual property, today announced ... full service global investment bank specializing in micro, ... note featuring Spherix. The report, authored ... Analyst at Chardan, was published on March 31, ...
(Date:4/1/2015)... National recruitment firm Slone Partners is ... Head of Sales at Optimal Medicine, an international digital ... Allen brings over 20 years experience in healthcare information ... companies including Dell Services Healthcare, Medsphere Systems and McKesson. ... fit for accomplishing the goals Optimal Medicine had for ...
Breaking Biology Technology:Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 2Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 3Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 2Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 3Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 4Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 5Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 6Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 7Chardan Capital Issues Industry Note Covering Spherix 2Chardan Capital Issues Industry Note Covering Spherix 3Slone Partners Fills Head of Sales at Optimal Medicine 2
... -- 3SBio Inc.,(Nasdaq: SSRX ), a ... marketing biopharmaceutical products primarily,in China, today announced that ... Financial,Officer, effective February 1, 2009. Since joining 3SBio ... the financial advisor for the company, providing advice,on ...
... Ireland, February 9, Shire plc (LSE: SHP, NASDAQ: ... Notice letters from Barr Laboratories, Inc.,("Barr) and Mylan, Inc. ... each case of the filing of an Abbreviated New ... and 1gm FOSRENOL(R),(lanthanum carbonate). , ...
... Feb. 9 , , ... new Progen board , Call by ... Significant funding shortfall identified in the Progen merger ... Requisition , Late last week Progen Pharmaceuticals Limited (ASX: PGL) responded ...
Cached Biology Technology:3SBio Inc. Appoints Mr. Bo Tan as Chief Financial Officer 2Shire Receives FOSRENOL Paragraph IV Notice Letters from Barr Laboratories and Mylan 2Cytopia and Other Progen Shareholders Maintain Call for Meeting 2Cytopia and Other Progen Shareholders Maintain Call for Meeting 3Cytopia and Other Progen Shareholders Maintain Call for Meeting 4
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
...
Biology Products: