Navigation Links
Novel intravaginal ring shows promise for HIV prevention
Date:7/2/2014

ining a different drug. These deliver the drug directly to the vaginal mucosa, via channels in the elastomer ring, which exposes the pods to vaginal fluids.

An additional requirement for safety and efficacy is that the ring must not trigger immune defenses, and their associated inflammation, as that could encourage HIV infection by compromising the integrity of the mucosal barrier, as well as by recruiting and activating immune cells that are the virus's targets. And in fact, the immune system, and the vaginal microbiome were undisturbed.

Baum notes that the pig-tailed macaque model is an ideal surrogate for humans. "The model has similarities with the human menstrual cycle, vaginal architecture and vaginal microbiome, and the ability to conduct efficacy studies with simian-human immunodeficiency virus," he says.

"Macaques cannot be infected with HIV, so scientists have developed a hybrid virus, simian-human immunodeficiency virus, that infects the monkeys and leads to a disease much like AIDS," Baum explains. This virus contains parts of the human immunodeficiency virus, and is susceptible to many HIV drugs, he says. "This is the state of the art for studying HIV/AIDS in vivo."

The two drug combinations tested include Truvada, which consists of emtricitabine and tenofovir disoproxil fumarate, and Truvada plus maraviroc, which works by blocking the chemokine receptor, CCR5, which is a target entryway of HIV.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel dark matter searches, identifying muzzle flashes, and more at 2014 APS DAMOP annual meeting
2. A novel disease-preventing antioxidant pathway
3. Novel drug target linked to insulin secretion and type 2 diabetes treatment
4. Illinois researchers combine weak chemical forces to strengthen novel imaging technology
5. Novel RNAi therapy silences mutated Huntingtons disease gene and reduces symptoms
6. Sanford-Burnham and Daiichi Sankyo form alliance to study novel drug targets
7. Novel ORNL technique enables air-stable water droplet networks
8. High-efficiency water treatment using light using a novel UV-light system
9. Novel antioxidant makes old arteries seem young again, CU-Boulder study finds
10. Salk Institute study identifies novel regulator of key gene expression in cancer
11. Novel marker discovered for stem cells derived from human umbilical cord blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION METHOD ... convenient and secure method to make payments.  With ... methods, introduced with its groundbreaking voice-direct payment patent ...
(Date:7/9/2015)... 2015  Unchained Labs just can,t get enough ... Avid Nano. Avid Nano designs, develops and manufactures ... Also today, Unchained Labs UNcaged the ... use protein sizing system. The pUNk is a ... size, size distribution, aggregation population and molecular weight. ...
(Date:7/8/2015)... N.J. and NEW YORK , July 8, ... Guidepoint today announced BD & Guidepoint Mentor, ... with free access to Guidepoint,s expert network services. ... are developing cutting-edge technologies to improve healthcare delivery and ... research manager, each start-up entrepreneur will be able to ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... boosts in the microbial production of clean, green and ... of a new technique in synthetic biology by researchers ... Institute (JBEI). This new technique dubbed a ... in microbes during the production of fatty acid-based fuels ...
... York, N.Y. (March 26, 2012) Autism Speaks, the ... the award of new research grants totaling $1.1 million ... I are extraordinarily proud of Autism Speaks, continued funding ... open new avenues to understanding autism," said Autism Speaks ...
... and narwhals live solely in the cold waters of the ... not have always been the case. They recently described a ... belugas and narwhals that lived some 3-4 million years ago ... when its modern-day relatives evolved to live only in northern ...
Cached Biology News:New synthetic biology technique boosts microbial production of diesel fuel 2New synthetic biology technique boosts microbial production of diesel fuel 3New synthetic biology technique boosts microbial production of diesel fuel 4Autism Speaks awards $1.1 million to fund high priority studies 2Autism Speaks awards $1.1 million to fund high priority studies 3Ancient whale species sheds new light on its modern relatives 2
(Date:8/4/2015)... , ... August 05, 2015 , ... ... the “Product Handbook – the complete product line.” The handbook provides a ... “This new product handbook consolidates our complete standard product offering into an easy-to-navigate ...
(Date:8/4/2015)... Inc. (NYSE: BIOA ), a leader in renewable ... ending June 30, 2015. Highlights included: , The Sarnia ... The final cost of the Sarnia plant is projected ... high end of the estimate communicated at the onset ... The company announced commercial collaborations in two targeted industry ...
(Date:8/4/2015)... ... August 04, 2015 , ... Graphite Metallizing Corporation, ... equipment, announces the appointment of Dennis Rawle as European Director of Sales. Rawle ... recently, he was General Manager and Technical Sales Manager for pump products at ...
(Date:8/4/2015)... PORTLAND, Oregon , August 4, 2015 /PRNewswire/ ... published by Allied Market Research, titled, "World Cardiac ... global cardiac biomarker market would generate the revenue ... of 18.9% from 2015 to 2020. Cardiac Troponins ... throughout the forecast period due to high sensitivity ...
Breaking Biology Technology:Spirax Sarco releases Product Handbook 2BioAmber Reports Second Quarter 2015 Financial Results 2BioAmber Reports Second Quarter 2015 Financial Results 3BioAmber Reports Second Quarter 2015 Financial Results 4BioAmber Reports Second Quarter 2015 Financial Results 5BioAmber Reports Second Quarter 2015 Financial Results 6BioAmber Reports Second Quarter 2015 Financial Results 7BioAmber Reports Second Quarter 2015 Financial Results 8BioAmber Reports Second Quarter 2015 Financial Results 9BioAmber Reports Second Quarter 2015 Financial Results 10BioAmber Reports Second Quarter 2015 Financial Results 11BioAmber Reports Second Quarter 2015 Financial Results 12Dennis Rawle Joins Graphite Metallizing Corporation 2Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 2Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 3Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 4Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 5
... SAN DIEGO, March 6 Cadence Pharmaceuticals,Inc. (Nasdaq: ... in-licensing,developing and commercializing proprietary product candidates principally,for use ... will release its,fourth quarter and full year ended ... market on Wednesday, March 12, 2008., Cadence ...
... PICK: Pinpoint accuracy: DNA vaccines that home in on ... pursued to develop new vaccines against infectious diseases is ... a DNA vaccine, the body converts the information in ... immune response. However, current DNA vaccines induce relatively weak ...
... Elsevier, the world-leading publisher of scientific, technical and ... Materials 2009: The First International Conference on Multifunctional, ... Tours, France, 15-19 March 2009. , Research ... growth in published papers in recent years with ...
Cached Biology Technology:Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss Fourth Quarter and Full Year 2007 Financial Results and Clinical Program Overview on March 12, 2008 2JCI online early table of contents: March 6, 2008 2JCI online early table of contents: March 6, 2008 3JCI online early table of contents: March 6, 2008 4Hybrid materials: Exciting interdisciplinary field offering future solutions for industry 2
Anti-Human Factor XIII HRPO (Polyclonal) (sheep IgG)...
... Mouse monoclonal [F30 P7 D7 ... for all tested applications). ... conjugated to Ovalbumin, corresponding to amino ... Entrez Gene ID: ...
E2F-5...
LAB/Probe Mouse-Rabbit DAB Kit...
Biology Products: